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Re: Organizing our diag./symptoms med s-effects

Posted by Jon on November 28, 2000, at 9:33:45

In reply to Re: Organizing our diag./symptoms & med s-effects , posted by JohnL on November 2, 1999, at 3:49:52

Hello John,

> PRIMARY SYMTOM: Anhedonia. Lack of pleasure,
> All the SSRIs. Good for general depressive > TCAs Notriptyline, Protriptyline. Couldn't > Lithium. Worsened tinnitus. Unfair trial.
> Lamictal. Helpful on all symptoms except the > Naltrexone. No effect. Neutral.
> Herbs, gingko, ginseng. Mild energy boost,

OK, you may not be reading this thread anymore as you posted your message one-year ago, but I suggest you may have a problem with your opioid receptor system. I don't think 5-HT or NA would play a major role in anhedonia, the best candidates being either DA or opioids.

The rewarding properties of hedonic drugs like cocaine and heroin stimulate the DA and opioid systems respectively. Unfortunately im not aware of any medications that can re-balance these systems without creating physical dependency, which you really don't want. However, if you have ever had any experience with either of these classes of drugs can you please let me know as I'm researching anhedonia at the moment.

My email is (in case this list auto-deletes email addresses: jon_walker at popmail dot com).

Do small amount of codeine help?

Hope you're doing OK.


> SUMMARY: Anhedonia I believe is a distinct beast that can occur during depression or occur as a completely seperate monster.




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