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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by B2chica on August 2, 2011, at 10:28:10
so i put a call (well 4) to pdoc yesterday trying to find out what to do cuz i was still spiraling down.
since i didnt hear back i decided to try a dopamine bouce effect.
since i'm on perphenazine and zyprexa (dopamine antagonists) i decided this weekend to do this so starting sat i only took night dose of perphenazine then last night (yesterday was REAL BAD) i did not take zyprexa.ya i had a tricky time getting to sleep last night fast heartrate, anxiety but suprisingly used breathing exercises and that seemed to help calm me enough to zonk out around midnight.
then i woke easily at 5, and went out to exercise. did weights and short swim.
i felt great leaving fitness center. Still feel pretty decent.
i feel depression lingering in background but i'm doing all the external things i can to keep going.i didnt ever realize how much zyprexa hindered my processing.
i've gotten quite spoiled to my normal thinking patterns and speed.
and i felt dull and slow compared to that. Not to mention depression seemed to either keep coming and getting worse either because of the drugs or despite them.even if it only works for one day...i'll take it.
i'm going to spend extra time with my girls tonight.
********************************
i know that stimulants always have helped me greatly with my mood. adderall especially.maybe i need to look more at DRI's
like Provigil or such.are there any new drugs out there that focus on Dopamine along with serotonin?
i thought i read a few months ago on here that there were a few in the lurk.
Posted by floatingbridge on August 2, 2011, at 11:03:05
In reply to trying a bounce-back dopamine effect, posted by B2chica on August 2, 2011, at 10:28:10
Thanks for the update. I was wondering how things were going for you.
Don't know about the DRI you mention.
Take those days as they come :-)
Posted by Phillipa on August 2, 2011, at 11:08:46
In reply to Re: trying a bounce-back dopamine effect, posted by floatingbridge on August 2, 2011, at 11:03:05
Wow both out early in am at the gym with two little ones and then full day at work. Sounds like you are doing really well. Phillipa
Posted by B2chica on August 2, 2011, at 11:57:18
In reply to Re: trying a bounce-back dopamine effect, posted by Phillipa on August 2, 2011, at 11:08:46
thats how i have been...now you know why i cant settle anymore...its been too good this summer. since i started perphenazine (though not root cause) in april its been quite well.
June/July was great. i even had a great performance eval at work.However, the last two weeks have not been well. not exercising as much, Now i havent exercised at all since last monday (right before i started zyprexa). and this morning, the day after i stopped. it made me too lethargic, not just in the morning but all day as well.
Posted by B2chica on August 2, 2011, at 11:59:51
In reply to Re: trying a bounce-back dopamine effect, posted by floatingbridge on August 2, 2011, at 11:03:05
DRI
Dopamine Reuptake Inhibitor.
the only one i'm on is adderall but things like provigil and the like are DRI'sBut someone mentioned a while ago that there were some new meds coming down the pipes that were FINALLY looking more at dopamine Reuptake and dopamine release.
but i cant remember the website to see what phase they are in.b2c.
Posted by floatingbridge on August 2, 2011, at 12:38:57
In reply to Re: trying a bounce-back dopamine effect » floatingbridge, posted by B2chica on August 2, 2011, at 11:59:51
I thought adderall was a dopamine agonist, similar to Dexedrine.
Is that different from a DRI? Now I'm very curiuos....
> DRI
> Dopamine Reuptake Inhibitor.
> the only one i'm on is adderall but things like provigil and the like are DRI's
>
> But someone mentioned a while ago that there were some new meds coming down the pipes that were FINALLY looking more at dopamine Reuptake and dopamine release.
> but i cant remember the website to see what phase they are in.
>
> b2c.
Posted by sigismund on August 2, 2011, at 13:10:20
In reply to trying a bounce-back dopamine effect, posted by B2chica on August 2, 2011, at 10:28:10
>are there any new drugs out there that focus on Dopamine along with serotonin?
I suppose agomelatine (5ht2c antagonism > increased dopamine somewhere) and tianeptine (serotonin reuptake accelerator?).
Posted by sigismund on August 2, 2011, at 13:12:07
In reply to Re: trying a bounce-back dopamine effect » B2chica, posted by floatingbridge on August 2, 2011, at 12:38:57
Is Ritalin a DRI?
Nothing would beat chewing coca leaves and going for long walks in the Andes.
Posted by B2chica on August 2, 2011, at 13:31:44
In reply to Re: trying a bounce-back dopamine effect, posted by sigismund on August 2, 2011, at 13:12:07
close, ritalin is a dopamine releasing agent.
i'm currently on adderall.
and both ritalin and adderall have been key players in my treatment consistently.ah. yes.
coca leaves would be quite good.
Posted by SLS on August 2, 2011, at 13:40:47
In reply to trying a bounce-back dopamine effect, posted by B2chica on August 2, 2011, at 10:28:10
> maybe i need to look more at DRI's
> like Provigil or such.I am dubious that Provigil is acting as a DRI in areas of the brain important to treat depression. Most of its wake-promoting effect is due to its actions to increase the release of orexins, also called hypocretins, from the hypothalamus. That's not to say that Provigil does not bind to DA transporter. It does. However, it is ambiguous as to the importance of this property.
- Scott
Posted by sigismund on August 2, 2011, at 13:58:03
In reply to Re: trying a bounce-back dopamine effect, posted by B2chica on August 2, 2011, at 13:31:44
I remember Linkadge talking about how the actions of Ritalin and Dexedrine we a little different.
Perhaps Scott may know?
Posted by B2chica on August 2, 2011, at 14:22:58
In reply to Re: trying a bounce-back dopamine effect » B2chica, posted by SLS on August 2, 2011, at 13:40:47
thank you Scott.
it is Very good to hear from you.
i actually trust your knowledge better than any website i can find.. :)so do you think that Provigil is used (successfully in some cases) to treat depression? i know i've heard its use on this board before but not sure about the results.
and are there other agents that act similar (release of orexins from hypothalamus) that may work in positively effecting mood?
Appreciate any feedback
Thanks.
Posted by SLS on August 2, 2011, at 17:05:11
In reply to Re: trying a bounce-back dopamine effect » SLS, posted by B2chica on August 2, 2011, at 14:22:58
> so do you think that Provigil is used (successfully in some cases) to treat depression?
I get the impression that Provigil (modafinil) may offer some increase in mental energy and perhaps some mild mood brightening, but is not very robust as an antidepressant. A minority of people actually feel worse on Provigil. I had a horrible experience with it. I wouldn't give Provigil more than two weeks to begin working, even when augmenting it with a standard antidepressant.
Some people report experiencing a greater antidepressant effect from adrafinil than from its daughter dug, modafinil. Adrafinil is available in Europe.
Methylphenidate is more of a DA reuptake inhibitor than it is a DA releaser. With amphetamine, the opposite is true.
If one were to follow the advice of Sheldon Preskorn, MD, he would look more closely at Wellbutrin for DA reuptake inhibition.
Nomifensine and amineptine were putatively effective antidepressants that were available in Europe in the 1980's. Both drugs potently inhibited the reuptake of dopamine. Unfortunately, they were withdrawn from the market for various reasons.
The triple reuptake inhibitors have disappeared from the listings of investigational new drugs provided by Shawn Thomas:
http://www.neurotransmitter.net/newdrugs.html
- Scott
Posted by B2chica on August 3, 2011, at 11:08:52
In reply to Re: trying a bounce-back dopamine effect » B2chica, posted by SLS on August 2, 2011, at 17:05:11
Thnx SCott.
that figures. i hope they continue to explore dopamine with AD's.
wellbutrin worked Great on me i was able to use that one effectively for about a year. then it (of course) pooped out. that was in 2004 or 5 cant remember. but then tried again in 2008 tried both generics (teva and lemon?) then the real deal. nothing worked.all i can say is ....crap.
crap crap crap... :(
b2c.
Posted by floatingbridge on August 3, 2011, at 11:56:03
In reply to Re: trying a bounce-back dopamine effect » SLS, posted by B2chica on August 3, 2011, at 11:08:52
B2c, following along here, I read the wiki entry for ritalin. It says it is both an agonist and reuptake inhibitor of dopamine, if I got that right.
That bounced me over to wiki on Dexedrine, my old to-go drug which, surprise, temporarily inhibits MAO's.
I am doing better on Emsam that pristiq. I had to ditch dex because of instability and ineffectiveness. Ditched pristiq for same reasons. Forgive me if you have stopped pristiq or not,
I can't remember.Just my observations, not an endorsement. Because I do have ADD stuff, too :-/. Wellbutrin was a miracle for about six months years ago, then just absolutely quit. I would feel such
inner agitation, I would fall asleep at my desk :-/.Sorry it's crap, crap, crap, right now. But it won't always be that way for you.
>Thnx SCott.
> that figures. i hope they continue to explore dopamine with AD's.
>
>
> wellbutrin worked Great on me i was able to use that one effectively for about a year. then it (of course) pooped out. that was in 2004 or 5 cant remember. but then tried again in 2008 tried both generics (teva and lemon?) then the real deal. nothing worked.
>
> all i can say is ....crap.
> crap crap crap... :(
> b2c.
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