![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 38 to 62 of 62. Go back in thread:
Posted by Zyprexa on September 8, 2008, at 16:58:54
In reply to Re: Glycine Antipsychotic » Zyprexa, posted by Larry Hoover on September 8, 2008, at 7:40:48
What does the "L" mean? Is L-Glycine the same as Glycine? Or does L mean Natural?/Organic?
Posted by ILADVOCATE on September 8, 2008, at 17:19:59
In reply to Re: Glycine Antipsychotic » Larry Hoover, posted by Zyprexa on September 8, 2008, at 16:58:54
> What does the "L" mean? Is L-Glycine the same as Glycine? Or does L mean Natural?/Organic?
Its part of the full name of the amino acid. Any pure form of glycine such as:
http://www.vitalnutrients.net/vnestore/detail.asp?product_id=VNGLY
Which I take is fine.
Posted by ILADVOCATE on September 8, 2008, at 17:25:27
In reply to Re: Glycine not As a Primary Antipsychotic » ILADVOCATE, posted by Zyprexa on September 8, 2008, at 16:55:40
> I've noticed that zyprexa dose size is the determining factor as how much the blood suger is going up. My blood sure results have not gotten worse over the years. And if I stop the zyprexa, blood suger is normal again.
Well then it hasn't worsened into type 2 diabetes. But that doesn't mean it couldn't and Zyprexa is the clinically proven worst offender for that. You are right to stay on what is working for you but keep updating with what is coming out. There are a couple that might be out soon. They are the standard dopamine based ones but they are related to Abilify and would have less of a risk than Zyprexa. Either way its good to keep updated. Check this link and bookmark it as it updates itself:
http://www.psychmeds123.info/
Posted by Larry Hoover on September 8, 2008, at 17:32:38
In reply to Re: Glycine Antipsychotic » Larry Hoover, posted by Zyprexa on September 8, 2008, at 16:58:54
> What does the "L" mean? Is L-Glycine the same as Glycine? Or does L mean Natural?/Organic?
The L stands for levo (left), whereas D stands for dextro (right). They describe the twisting of light by crystals of the pure substance. I know that doesn't mean much to anyone but a chemist.....
There is no L-glycine. It's all just glycine. And it doesn't twist light passing through its crystals.
Some molecules have structures that differ in "handedness", like matching right and left gloves. One example from among the amino acids is phenylalanine. You can buy DLPA (D-,L-phenylalanine) which is a mixture of the two structures. It's all phenylalanine, but half is left-twisting, and half is right-twisting. You can tell it's man-made, because it is such a mixture.
In nature, virtually without exception, only the L-twisting amino acids exist, because the twisting matters to protein structure. So, natural source phenylalanine would be pure L-phenylalanine. However, the converse is not necessarily true; pure L-phenylalanine can be man-made.
Lar
Posted by bleauberry on September 8, 2008, at 21:47:17
In reply to Glycine As a Primary Antipsychotic, posted by ILADVOCATE on September 6, 2008, at 13:59:22
Jereon needs to read this thread.
My psych doc also spoke very highly of glycine for psychotic symptoms and anxiety symptoms.
Posted by ILADVOCATE on September 8, 2008, at 21:53:04
In reply to Re: Glycine as Antipsychotic - JEREON !!!!!, posted by bleauberry on September 8, 2008, at 21:47:17
> Jereon needs to read this thread.
>
> My psych doc also spoke very highly of glycine for psychotic symptoms and anxiety symptoms.
Then he must be well informed. Is he a psychopharmocologist? Where did he get this information from? I thought mine was the only one using it outside of study? I'd be interested to know.
Posted by bleauberry on September 9, 2008, at 18:02:04
In reply to Re: Glycine as Antipsychotic - JEREON !!!!!, posted by ILADVOCATE on September 8, 2008, at 21:53:04
> > My psych doc also spoke very highly of glycine for psychotic symptoms and anxiety symptoms.
> Then he must be well informed. Is he a psychopharmocologist? Where did he get this information from? I thought mine was the only one using it outside of study? I'd be interested to know.
>Actually no, not a psychopharmacologist. A regular MD with an additional license in Naturopathy, specializing in environmental toxicity. He warns right up front he is not a psychiatrist and prefers to use medications only after efforts have been made at allowing the body to naturally heal itself. Which is where Glycine comes into play. Glycine is a common supplement with doctors trained in naturopathy. It is a common amino acid in our bodies, but some people just need more of it than their bodies create. Glycine is inhibitory, a cousin of GABA and serotonin.
Also, I saw a Nurse Practioner with a license in Psychiatry a couple years ago. She also liked to try natural things first. At the time, anxiety was killing me. She said to try a combination of GABA and Glycine. GABA was weird. Sometimes it felt calming, sometimes depressing, and sometimes activating. It was unpredictable. But glycine was immediate calming every time. It just stopped all the racing stuff in its tracks. A little too much actually. For being a natural substance our bodies create, it can be powerful stuff. I can easily see how it would be good for psychosis, delusions, anxiety, restlessness, or akathisia, but I cannot see how it would be much good for negative symptoms.
Anyway, glycine is nothing new among doctors who have additional training in natural healing strategies. It has other uses besides just psychiatry. In the psychopharmacologist field however, I can see how they view it as some new discovery. They are so shielded in their isolated worlds of clinical studies, pharmaceutic rep seminars, and scientific books, that they are quite novice at basic biological functions involving things like glycine, magnesium, cortisol, and such.
I am very excited glycine is helping you. Actually, when I first read your post I just said "AWESOME!". The medical world I think sometimes makes things seem more difficult than they actually are. I mean, who would have ever thought, that stupid bottle of $10 Glycine at the health food store would do what $300 megapower antipsychotics couldn't?
Posted by iladvocate on September 9, 2008, at 21:36:07
In reply to Re: Glycine as Antipsychotic - » ILADVOCATE, posted by bleauberry on September 9, 2008, at 18:02:04
> > > My psych doc also spoke very highly of glycine for psychotic symptoms and anxiety symptoms.
> > Then he must be well informed. Is he a psychopharmocologist? Where did he get this information from? I thought mine was the only one using it outside of study? I'd be interested to know.
> >
>
> Actually no, not a psychopharmacologist. A regular MD with an additional license in Naturopathy, specializing in environmental toxicity. He warns right up front he is not a psychiatrist and prefers to use medications only after efforts have been made at allowing the body to naturally heal itself. Which is where Glycine comes into play. Glycine is a common supplement with doctors trained in naturopathy. It is a common amino acid in our bodies, but some people just need more of it than their bodies create. Glycine is inhibitory, a cousin of GABA and serotonin.
>
> Also, I saw a Nurse Practioner with a license in Psychiatry a couple years ago. She also liked to try natural things first. At the time, anxiety was killing me. She said to try a combination of GABA and Glycine. GABA was weird. Sometimes it felt calming, sometimes depressing, and sometimes activating. It was unpredictable. But glycine was immediate calming every time. It just stopped all the racing stuff in its tracks. A little too much actually. For being a natural substance our bodies create, it can be powerful stuff. I can easily see how it would be good for psychosis, delusions, anxiety, restlessness, or akathisia, but I cannot see how it would be much good for negative symptoms.
>
> Anyway, glycine is nothing new among doctors who have additional training in natural healing strategies. It has other uses besides just psychiatry. In the psychopharmacologist field however, I can see how they view it as some new discovery. They are so shielded in their isolated worlds of clinical studies, pharmaceutic rep seminars, and scientific books, that they are quite novice at basic biological functions involving things like glycine, magnesium, cortisol, and such.
>
> I am very excited glycine is helping you. Actually, when I first read your post I just said "AWESOME!". The medical world I think sometimes makes things seem more difficult than they actually are. I mean, who would have ever thought, that stupid bottle of $10 Glycine at the health food store would do what $300 megapower antipsychotics couldn't?
>
>
>I agree but psychiatry is onto this one. Glycine or certainly one of the glutamate antagonists will be the next generation of antipsychotics and the more recoveries I can identify the more they will take this seriously about fast tracking this class of medications through study. I cannot post my psychopharmocologist's name here obviously nor do I feel comfortable posting the name of the non profit I am board president of. But my psychiatrist allowed me to write a letter from my non profit to the director of the American Psychiatric Association mentioning his name and phone number and encouraging her to call him. I've been online everywhere to spread the word but they are finding out and once they get this class of medications out I'm sure they will replace all the dopamine based antipsychotics they have now. Science has finally caught up with us.
Posted by mike1975 on September 10, 2008, at 21:12:11
In reply to Re: Glycine as Antipsychotic -, posted by iladvocate on September 9, 2008, at 21:36:07
hi iladvocate,
First sorry for my English. It's not my first language.
I wanted to ask you how fast glycine started to work and at what dosage. I tried it before and it did nothing for me. I usually get at least portial response from supplements.
To everyone, did you guys had any luck with grapeseed extract?
Thank you very much
Mike
Posted by ILADVOCATE on September 10, 2008, at 22:56:33
In reply to Re: Glycine as Antipsychotic - » iladvocate, posted by mike1975 on September 10, 2008, at 21:12:11
> hi iladvocate,
>
> First sorry for my English. It's not my first language.
>
> I wanted to ask you how fast glycine started to work and at what dosage. I tried it before and it did nothing for me. I usually get at least portial response from supplements.
>
> To everyone, did you guys had any luck with grapeseed extract?
>
> Thank you very much
>
> MikeIt took several months to build up to 20 grams which is a starting dosage. It varied upwards after that to 26 grams which is a bit too much for me and now its at 24 grams but in studies it went up to 40 grams. I then was allowed to titrate off the Risperdal completely but slowly. I don't know much about grapeseed extract though I'm on some natural remedies (rhodiola, saw palmetto) but as I said to someone else glycine is not just a "supplement". Its an antipsychotic in Phase II FDA and should be taken under a psychiatrist's care. If someone is taking it by themselves already its probably not a good idea but that is their choice. I just want to make sure anyone who reads this checks with their psychiatrist first and the more recoveries I can identify and bring to the light the more psychiatrists will want to use it.
Posted by dade on September 11, 2008, at 1:37:21
In reply to Re: Glycine as Antipsychotic -, posted by ILADVOCATE on September 10, 2008, at 22:56:33
> It took several months to build up to 20 grams which is a starting dosage. It varied upwards after that to 26 grams which is a bit too much for me and now its at 24 grams but in studies it went up to 40 grams. I then was allowed to titrate off the Risperdal completely but slowly. I don't know much about grapeseed extract though I'm on some natural remedies (rhodiola, saw palmetto) but as I said to someone else glycine is not just a "supplement". Its an antipsychotic in Phase II FDA and should be taken under a psychiatrist's care. If someone is taking it by themselves already its probably not a good idea but that is their choice. I just want to make sure anyone who reads this checks with their psychiatrist first and the more recoveries I can identify and bring to the light the more psychiatrists will want to use it.
But i thought it WAS a supplement available at healthfood stores? maybe the dosage is what designates it as a drug? it is THE same Glycine you get from your health food store?
And is it usefull for Manic states, mood issues? dose?
Thanks
Thanks
Posted by ILADVOCATE on September 11, 2008, at 2:16:42
In reply to Re: Glycine as Antipsychotic - » ILADVOCATE, posted by dade on September 11, 2008, at 1:37:21
> > It took several months to build up to 20 grams which is a starting dosage. It varied upwards after that to 26 grams which is a bit too much for me and now its at 24 grams but in studies it went up to 40 grams. I then was allowed to titrate off the Risperdal completely but slowly. I don't know much about grapeseed extract though I'm on some natural remedies (rhodiola, saw palmetto) but as I said to someone else glycine is not just a "supplement". Its an antipsychotic in Phase II FDA and should be taken under a psychiatrist's care. If someone is taking it by themselves already its probably not a good idea but that is their choice. I just want to make sure anyone who reads this checks with their psychiatrist first and the more recoveries I can identify and bring to the light the more psychiatrists will want to use it.
>
> But i thought it WAS a supplement available at healthfood stores? maybe the dosage is what designates it as a drug? it is THE same Glycine you get from your health food store?
>
> And is it usefull for Manic states, mood issues? dose?
>
> Thanks
>
> ThanksThe pills you get at health food stores are useless. You have to order the pure powdered form the company but that's very useful and anyone can order it. It just needs to be taken under a psychiatrist's care. Its an unregulated "supplement" but when properly used its an antipsychotic. Like most antipsychotics it has some effect on mania but is not a full mood stabilizer. And although it can help with mania in doing that without a mood stabilizer if one has schizoaffective, such as with me, it worsened depression so like current antipsychotics, if you have schizoaffective it will stil require a mood stabilizer.
Posted by Jeroen on September 15, 2008, at 12:28:45
In reply to Re: Glycine as Antipsychotic - JEREON !!!!!, posted by ILADVOCATE on September 8, 2008, at 21:53:04
hi thanks, i just read it, im about to give lithium a try first,
do you feel great with glycine
Posted by iladvocate on September 15, 2008, at 12:49:47
In reply to Re: Glycine as Antipsychotic - JEREON !!!!!, posted by Jeroen on September 15, 2008, at 12:28:45
> hi thanks, i just read it, im about to give lithium a try first,
>
>
> do you feel great with glycineIt depends on what it is for. Glycine is for use as an antipsychotic. Lithium is a mood stabilizer. Glycine would not be used for bipolar disorder unless the person had bipolar with psychotic features. Lithium is still used as a mood stabilizer but has a lot of severe side effects including cognitive confusion, severe weight gain and sedation. Also there are monthly required bloodtests. Many psychiatrists will not use Lithium for after 10 years because the potential of long term kidney damage leading to kidney failure which has happenned to 5 people I know. Many psychiatrists prefer to start a person with Lamictal which except for the 1 in a thousand potential of a rare rash is effective and much safer. If you want to know more about Lamictal as an alternative or the long term side effects of Lithium or what are the reccommended mood stabilizers start or join a thread about that. Glycine has proven effective enough in recovery as an antipsychotic that my psychopharmocologist stated to the director of a major psychiatric hospital that my recovery on glycine was "as good as or better than any FDA approved medication as an antipsychotic". I provided testimony at a major psychiatric hospital, the first to research Clozaril in the United States and they are researching glutamate antagonists at that hospital and my case study will be written up in a psychiatric journal. So far they have not been studied as mood stabilizers though.
Posted by mike1975 on September 21, 2008, at 15:29:14
In reply to Re: Glycine as Antipsychotic - JEREON !!!!!, posted by iladvocate on September 15, 2008, at 12:49:47
hi everyone,
It seems that the latest study found glycine ineffective:
The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments.
Buchanan RW, Javitt DC, Marder SR, Schooler NR, Gold JM, McMahon RP, Heresco-Levy U, Carpenter WT.
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA.
OBJECTIVE: Patients with schizophrenia frequently present with negative symptoms and cognitive impairments for which no effective treatments are known. Agents that act at the glycine site of the N-methyl-D-aspartic acid (NMDA) glutamatergic receptor have been suggested as promising treatments for moderate to severe negative symptoms and cognitive impairments. METHOD: The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST) was a 16-week double-blind, double-dummy, parallel group, randomized clinical trial of adjunctive glycine, D-cycloserine, or placebo conducted at four sites in the United States and one site in Israel. The participants were 157 inpatients and outpatients who met DSM-IV criteria for schizophrenia or schizoaffective disorder and retrospective and prospective criteria for moderate to severe negative symptoms without marked positive, depressive, or extrapyramidal symptoms. The primary outcome measures were the average "rate of change" of Scale for the Assessment of Negative Symptoms (SANS) total scores and change in the average cognitive domain z scores. RESULTS: There were no significant differences in change in the SANS total score between glycine and placebo subjects or D-cycloserine and placebo subjects. A prespecified test for the site-by-treatment-by-time interaction was significant in post hoc tests. One site had greater reduction in the SANS total score for patients receiving D-cycloserine relative to patients receiving placebo. A second site had greater reduction in the SANS total score for placebo patients compared with glycine patients. There were no significant differences between glycine and placebo or D-cycloserine and placebo subjects on the average cognition z score. CONCLUSIONS: The study results suggest that neither glycine nor D-cycloserine is a generally effective therapeutic option for treating negative symptoms or cognitive impairments.
Any thoughts?
Take care
Mike
Posted by iladvocate on September 21, 2008, at 15:54:40
In reply to Re: Glycine as Antipsychotic - JEREON !!!!!, posted by mike1975 on September 21, 2008, at 15:29:14
> hi everyone,
>
> It seems that the latest study found glycine ineffective:
>
> The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments.
>
> Buchanan RW, Javitt DC, Marder SR, Schooler NR, Gold JM, McMahon RP, Heresco-Levy U, Carpenter WT.
>
> Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA.
>
> OBJECTIVE: Patients with schizophrenia frequently present with negative symptoms and cognitive impairments for which no effective treatments are known. Agents that act at the glycine site of the N-methyl-D-aspartic acid (NMDA) glutamatergic receptor have been suggested as promising treatments for moderate to severe negative symptoms and cognitive impairments. METHOD: The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST) was a 16-week double-blind, double-dummy, parallel group, randomized clinical trial of adjunctive glycine, D-cycloserine, or placebo conducted at four sites in the United States and one site in Israel. The participants were 157 inpatients and outpatients who met DSM-IV criteria for schizophrenia or schizoaffective disorder and retrospective and prospective criteria for moderate to severe negative symptoms without marked positive, depressive, or extrapyramidal symptoms. The primary outcome measures were the average "rate of change" of Scale for the Assessment of Negative Symptoms (SANS) total scores and change in the average cognitive domain z scores. RESULTS: There were no significant differences in change in the SANS total score between glycine and placebo subjects or D-cycloserine and placebo subjects. A prespecified test for the site-by-treatment-by-time interaction was significant in post hoc tests. One site had greater reduction in the SANS total score for patients receiving D-cycloserine relative to patients receiving placebo. A second site had greater reduction in the SANS total score for placebo patients compared with glycine patients. There were no significant differences between glycine and placebo or D-cycloserine and placebo subjects on the average cognition z score. CONCLUSIONS: The study results suggest that neither glycine nor D-cycloserine is a generally effective therapeutic option for treating negative symptoms or cognitive impairments.
>
> Any thoughts?
>
> Take care
>
> Mike
>Many of the double blind placebo studies have found inadaquete results for many medications. It should be noted also that glycine is just a compound and that there are other anti-psychotics in study that are glutamate antagonists that work in a more specific manner. Additionally, the study gave the glycine at one large dose whereas in myself it is short acting and needs to be titrating throughout the day. My psychopharmocologist will be publishing the results of my use of glycine as a primary antipsychotic. I testified last week at the psychiatric hospital that first developed Clozaril. My psychopharmocologist confirmed to the director of psychiatry there that my recovery with glycine was "as good as all approved FDA anti-psychotics or better". Obviously, one person's recovery does not confirm everyone's but it shows that although for some people it may be ineffective that for myself as identified through the same standards as used in the study I have made a full recovery and that other people might as well. They just need to keep researching more anti-psychotics in this class and other study classes of anti-psychotics as well. Every anti-psychotic currently available except for Clozaril (which has its own set of hazards) will eventually cause people to develop tardive dyskinesia (5% per person per year with the typicals, 2.5% per person per year with the atypicals) plus the ever present risk of diabetes. As well the tardive conditions are worse than they had originally let the public know such as tardive psychosis which I am in study for and am being treated with Zofran. This information was confirmed with my psychopharmocologist who let me publicize this but I cannot print his name and he works under standard clinical practice. Its too important to let these studies fall apart for other people's recovery.
Posted by Zyprexa on September 22, 2008, at 19:20:41
In reply to Re: Glycine as Antipsychotic - JEREON !!!!!, posted by mike1975 on September 21, 2008, at 15:29:14
That doesn't suprise me. I don't find glycine terable effective. It does have a nice lightly calming effect, keeps me from worrying. I don't take it alot of the time, just forget and dont' notice it. I often wonder if I should even still take it. But I do occasionaly and it helps a little.
Anyways,
Zyprexa
Posted by iladvocate on September 22, 2008, at 19:35:38
In reply to Re: Glycine as Antipsychotic - JEREON !!!!! » mike1975, posted by Zyprexa on September 22, 2008, at 19:20:41
> That doesn't suprise me. I don't find glycine terable effective. It does have a nice lightly calming effect, keeps me from worrying. I don't take it alot of the time, just forget and dont' notice it. I often wonder if I should even still take it. But I do occasionaly and it helps a little.
>
> Anyways,
> Zyprexa
I spoke to my psychopharmocologist who read the document but it mentioned specifically that glycine was not effective for negative symptoms in one study. It did mention that glutamenergic antipsychotics are worth studying. Obviously glycine is a compound and they are developing more targeted agents including a promising one in Phase II by Eli Lilly that is showing strong effects as a primary antipsychotic. That report was from two years ago according to my psychopharmocologist. He explained it to me in this regard and will be publishing my specific study. Obviously due to its nature as a compound in powder format glycine will not become an approved antipsychotic agent but it can and is paving the way for other antipsychotics that will be and still should be considered as an adjunct by psychopharmocologists and a primary if my results can be duplicated in the meantime with people who are unable to tolerate current antipsychotics or develop emergent tardive conditions or diabetes considering the health risks of Clozaril which although has not been shown to cause tardive can often worsen diabetes and for some people due to other disabilities or developing blood dyscreias cannot be taken at all. As for recovery each person is different with any medication, especially one in study.
Posted by desolationrower on September 22, 2008, at 22:21:51
In reply to Glycine and the Glutaminergic Agents, posted by iladvocate on September 22, 2008, at 19:35:38
Iladvocate, do you think this combination would be synergistic. Chronic memantine can increasing glycine bind sites & affinity. IT can also protect against nmda excitotoxicity. In general the combination would increase overall activation, and also preserve signal-to-noise. There appears to be a few positive case reports for memantine.
Of course, these medicines would likely be in the context of 5ht2/d2 antagonism, which is another variable which could throw things off.
-D/R
Posted by iladvocate on September 22, 2008, at 23:12:02
In reply to glycine + memantine, posted by desolationrower on September 22, 2008, at 22:21:51
> Iladvocate, do you think this combination would be synergistic. Chronic memantine can increasing glycine bind sites & affinity. IT can also protect against nmda excitotoxicity. In general the combination would increase overall activation, and also preserve signal-to-noise. There appears to be a few positive case reports for memantine.
> Of course, these medicines would likely be in the context of 5ht2/d2 antagonism, which is another variable which could throw things off.
> -D/RActually that works in the same fashion as Namenda which is being used as a mood stablizer experimentally. I was almost put on Namenda but since it like Memantine surpresses glutamate activity and glycine of course activates it the two could interact. If its ever been tried it would be a medical first and that should go through the various phases of studies before being attemped. However, as for 5ht2/d2 antagonism I know Zofran works in a similar manner (5htt3 antagonists) and that is being studied as an adjunct for schizophrenia and I find it beneficial in this regard and for the tardive conditions and most importantly what they are identifying as tardive psychosis (since it was used for psychosis from Parkinson's I figured it would be helpful and it was, I advocated to get on it, this one is going to a neurologist that the public would be familiar with). Zofran could be used safely but Namenda or Memantine could interact with glycine (or at the worst cancel each other out) so as I said let that one go through studies before even attempting.
Posted by Tomatheus on September 23, 2008, at 0:14:06
In reply to Re: glycine + memantine, posted by iladvocate on September 22, 2008, at 23:12:02
> Actually that works in the same fashion as Namenda which is being used as a mood stablizer experimentally. I was almost put on Namenda but since it like Memantine surpresses glutamate activity and glycine of course activates it the two could interact.
iladvocate,
Namenda and memantine are actually the same thing. Namenda is a trade name for memantine.
Tomatheus
Posted by Phillipa on September 23, 2008, at 20:14:33
In reply to Re: glycine + memantine » iladvocate, posted by Tomatheus on September 23, 2008, at 0:14:06
And zofran if I remember correctly is given for nausea from chemo IV when working? Love Phillipa
Posted by Phillipa on September 23, 2008, at 20:22:18
In reply to Re: glycine + memantine, posted by Phillipa on September 23, 2008, at 20:14:33
OOps googled it and wiki says it's investigational for schizophrenia copied a bit. Love Phillipa
Clinical uses
See also: 5-HT3 antagonist
The 5-HT3 receptor antagonists are the primary drugs used to treat and prevent chemotherapy-induced nausea and vomiting (CINV). Many times they are given intravenously about 30 minutes before beginning therapy. Ondansetron is also effective in controlling post-operative (PONV) and post-radiation nausea and vomiting, and is a possible therapy for nausea and vomiting due to acute or chronic medical illness or acute gastroenteritis.Although it is highly effective, its high cost had limited its use to controlling PONV and CINV- although it is now available in cheaper generic forms. It is also used off-label to treat hyperemesis gravidarum in pregnant women, but there is no conclusive data available on its safety in pregnancy, especially during the first trimester. It is also often used to treat cyclic vomiting syndrome; although there have been no formal trials to confirm efficacy, case reports suggest it can be helpful in some cases. The drug is administered 13 times daily, depending on the severity of nausea and/or vomiting. The normal oral dose for adults and children over the age of 12, is 8 mg initially, followed by a second dose of 8 mg, eight hours later. The drug is then administered once every 12 hours, usually not for more than 2-3 days. Following oral administration, it takes about 1.52 hours to reach maximum plasma concentrations. This drug is removed from the body by the liver and kidneys.
The clinical effect of ondansetron (and other drugs from the same group) can be potentiated by combining it with dexamethasone.
[edit] Investigational[edit] Schizophrenia
A 2006 double-blind, randomized controlled trial indicated that ondansetron may have value in the treatment of schizophrenia, as an adjunct to haloperidol. The study found the combination to significantly improve negative schizophrenia symptoms, and people taking both drugs experienced fewer of the adverse effects commonly associated with haloperidol;[2] an earlier, smaller, open-label trial had found ondansetron to be useful in treating antipsychotic-induced tardive dyskinesia in people with schizophrenia, and the study patients also showed significant improvement in the disease's symptoms
Posted by iladvocate on September 23, 2008, at 20:22:28
In reply to Re: glycine + memantine, posted by Phillipa on September 23, 2008, at 20:14:33
> And zofran if I remember correctly is given for nausea from chemo IV when working? Love Phillipa
That is its primary usage and what its been approved for but the other off label uses have been shown in a variety of studies (except for tardive psychosis which is still a hypothetical condition that they are trying to name as regards to me) as for an adjunct for schizophrenia, psychosis from Parkinsons' and tardive dyskinesia. However, because of the lack of it being approved for anything other than this primary usage, I am fighting my Medicare Part D provider for coverage even though my neurologist has no problem prescribing it and has agreed that it is highly effective.
Posted by ILADVOCATE on November 7, 2008, at 20:05:56
In reply to Re: glycine + memantine, posted by iladvocate on September 23, 2008, at 20:22:28
As follow up I learned that the Phase II glycine study is continuing all over the United States. I recieved correspondence back from Dr. Carpenter who is researching it in Maryland. Testimony was presented to Dr. Kane, director of psychiatry at Hillside Hospital. I recieved correspondence from the noted psychiatrist E. Fuller Torrey. And just today I recieved a full letter from the director of NAMI that they will be contacting my psychopharmcologist. And my psychopharmocologist who asked not to be named online but I can identify to any provider on the site who would have any questions allowed me to write to the director of the American Psychiatric Association and we both hope to recieve a word back. I'd like to thank the researchers who are studying the NDMA receptor modulates (what the glutaminergic agents are called technically) and their fine work in realizing what will be the future generation of antipsychotics. And as for glycine as it becomes more known by providers perhaps they will be interesting in initiating it into clinical practice. Although there are other novel classes of antipsychotics this is the most promising and considering that in gene studies people with schizophrenia were shown to be lacking in glutamate transmission this may be very well be a form of antipsychotic that will promote the full mental recovery I had without the risk of the synaptic brain damage that is tardive dyskinesia and what they are identifying in me as tardive psychosis (which is being treated with Zofran). And if people read this and are interesting in starting glycine it is available but please ask your provider but if your provider isn't familiar with it you can refer them to Dr. Javitt's study and as soon as mine is published it will be linked here too and perhaps they will consider it as an adjunct and depending on recovery rate possible as a primary, as a compound on its way to becoming the basis for a new generation of antipsychotics.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
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