Posted by iladvocate on September 22, 2008, at 23:12:02
In reply to glycine + memantine, posted by desolationrower on September 22, 2008, at 22:21:51
> Iladvocate, do you think this combination would be synergistic. Chronic memantine can increasing glycine bind sites & affinity. IT can also protect against nmda excitotoxicity. In general the combination would increase overall activation, and also preserve signal-to-noise. There appears to be a few positive case reports for memantine.
> Of course, these medicines would likely be in the context of 5ht2/d2 antagonism, which is another variable which could throw things off.
> -D/RActually that works in the same fashion as Namenda which is being used as a mood stablizer experimentally. I was almost put on Namenda but since it like Memantine surpresses glutamate activity and glycine of course activates it the two could interact. If its ever been tried it would be a medical first and that should go through the various phases of studies before being attemped. However, as for 5ht2/d2 antagonism I know Zofran works in a similar manner (5htt3 antagonists) and that is being studied as an adjunct for schizophrenia and I find it beneficial in this regard and for the tardive conditions and most importantly what they are identifying as tardive psychosis (since it was used for psychosis from Parkinson's I figured it would be helpful and it was, I advocated to get on it, this one is going to a neurologist that the public would be familiar with). Zofran could be used safely but Namenda or Memantine could interact with glycine (or at the worst cancel each other out) so as I said let that one go through studies before even attempting.
poster:iladvocate
thread:850659
URL: http://www.dr-bob.org/babble/20080915/msgs/853551.html