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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 6 to 30 of 30. Go back in thread:
Posted by dapper on June 20, 2008, at 16:16:04
In reply to Re: finding agolmelatine » linkadge, posted by Mishal on June 20, 2008, at 0:23:14
Very interesting the conducters of the study won't allow you to keep on the medication...I would have a strong freind/family member who doesnt take 'no' for an answer to look into that and talk to some people with power into letting you stay on it saying it will be life threatening to get off it....
Sure there are plenty of other options available, but who wants to go through the experiment process again and all the pain and suffering of finding something that works as effectively...Don't take no for an answer (at least I don't; if I dont have the energy or will to get my needs met, I send my girlfriend or stepmom after them. They know how to make waves!)
Posted by jrbecker76 on June 21, 2008, at 1:09:04
In reply to finding agolmelatine, posted by kengwen on June 16, 2008, at 22:30:36
> HELP!! In 3 weeks my year will be over for my participation in a study group for Agomelatine. This has been the best medication to actually treat my severe depressive disorder. One year ago I was truly ready to give up. I had had enough. I participated under duress in one last clinical trial and l must say it saved my life. Agomelatine has been the only medication that has worked for me. Now my year is ending in a few weeks and I have been informed I can no longer receive this medication until FDA approval!! What am I supposed to do?? No SSRI has ever been effective for me and I cannot believe that my succes on Agomelitine will be suddenly stopped. I am scared to death (literally). Can anyone help me find where I can go to continue my medication regimine? Is it available anywhere?? HELP
Kengwen-
I certainly sympathize with your situation. I was also in an agomelatine study and did fairly well with it. Although I wouldn't go as far as to reflect that it was the most impactful med that I have taken, it has definitely been the one with the most negligible side effects.
Now that the 6-month study is over, I'm back on my old standby of a low-dose Cymbalta and Nefazodone cocktail. If available in the future though, I would definitely look to use it again within my regimen.
In terms of receiving authorization for "compassionate use" -- to retain access of a drug after the end of a clinical trial -- this is not typically implemented for most antidepressant studies. Such dispensations are usually reserved for end-of-life or orphan drug trials for indications such as cancer, ALS, and the like. Obviously, this is disappointing for many of us who find significant benefit from study drugs.
Unfortunately, agomelatine is not yet made available anywhere on the market yet. However, agomelatine does have a chance of coming to market soon though. In the E.U., it is rumored that the EMEA might rule on Servier's resubmission of its marketing application as soon as this month. If deemed positive, however, it would most likely take another few months for pricing and manufacturing discussions to be finalized before it comes on market in most Euro countries. In the U.S., as you probably know, Novartis will wrap up Phase III trials within the next couple of months. If the data turns out significant, plans would be followed through on to submit to the FDA by end of year. Given the FDA's recent track record, a good guess is that it will take another 9-12 months from the time of submission for an FDA response and market availability.
I hope this at least offers a little hope for things on the horizon.
Best,
JB
Posted by johnj on June 21, 2008, at 12:40:35
In reply to Re: finding agolmelatine » kengwen, posted by jrbecker76 on June 21, 2008, at 1:09:04
Anybody have any thoughts on valdoxan being effective for OCD? Thank you
johnj
Posted by johnj on June 21, 2008, at 12:42:47
In reply to Re: finding agolmelatine » kengwen, posted by jrbecker76 on June 21, 2008, at 1:09:04
May I ask what is your dose of cymbalta and serzone as you said you take low doses. Is this combination helpful for sleep and anxiety? Do you take low doses because of med sensitivity (that is my problme).
regards
johnj
Posted by jrbecker76 on June 22, 2008, at 10:47:31
In reply to Re: finding agolmelatine » jrbecker76, posted by johnj on June 21, 2008, at 12:42:47
> May I ask what is your dose of cymbalta and serzone as you said you take low doses. Is this combination helpful for sleep and anxiety? Do you take low doses because of med sensitivity (that is my problme).
>
> regards
>
> johnjJohn-
I don't suffer from any OCD symptology, so I can't necessarily comment on its impact, however, agomelatine did have slight anxiolytic qualities.
As for my Cymbalta/Nefazodone, I have gone anywhere from 5-10 mg of Cymbalta together with 10-50mg of Nefazodone. Currently, I am on a dose of 7.5mg of Cymbalta combined with 10 mg of Nefazodone. As you guessed, I am very med-sensitive. I exhibit atypical features, and most likely would fall within a soft bipolar diagnosis.
The low-dose Nefazodone is a great off-setter to SSRI/SNRI side effects. It helps as a hypnotic, mild antidepressant/anxiolytic and adds even mood-stabilizing properties. It of course has its own side effects, but are typically less averse at lower doses. And despite the concerns of liver toxicity that were covered a few years ago, I still believe that the issue is minor when using lower doses and monitored properly.
A person suffering from treatment-resistant depression who might be looking to explore an add-on AP (e.g., Risperdal, Seroquel) should perhaps trial Nefazodone first.
When the newer class of 5-HT2a antagonist sleep agents reach market, I would consider trading in the Nefazodone for a compound with better selectivity.
Posted by cactus on June 23, 2008, at 16:18:34
In reply to finding agolmelatine, posted by kengwen on June 16, 2008, at 22:30:36
Why not try a lawyer, in combination with a pdoc, it can't hurt to try if it's your only hope. I hope you get what you need.
> HELP!! In 3 weeks my year will be over for my participation in a study group for Agomelatine. This has been the best medication to actually treat my severe depressive disorder. One year ago I was truly ready to give up. I had had enough. I participated under duress in one last clinical trial and l must say it saved my life. Agomelatine has been the only medication that has worked for me. Now my year is ending in a few weeks and I have been informed I can no longer receive this medication until FDA approval!! What am I supposed to do?? No SSRI has ever been effective for me and I cannot believe that my succes on Agomelitine will be suddenly stopped. I am scared to death (literally). Can anyone help me find where I can go to continue my medication regimine? Is it available anywhere?? HELP
Posted by NegCreep on June 24, 2008, at 12:30:36
In reply to Re: finding agolmelatine » kengwen, posted by Phoenix1 on June 17, 2008, at 19:54:21
Hi, I too am very interested in agomelatine. I sympathise with your situation and I know what its like to have the 1 drug that works suddenly taken away from you. For me it was citalopram, it and all other SSRI now give me painful gastritis , great! Currently Ive been put on a 50mg a night of the Tricyclic 'Dosulepin'. Three weeks in and its not too bad, little drowsy (nothing compared to 15mg mirtazapine) and tiny bit of dry mouth. Anxiety and mood seem ok, so maybe you should give it a go.
I'm also very glad to hear of someone having a positive experience with Agomelatine. I've been following the progress of this drug for about a year now and it does sound like something pretty special for depressiona and anxiety. I was wondering if you can tell me what its like for sexual side effects? (they claim it has none!).
Posted by undopaminergic on June 25, 2008, at 4:18:00
In reply to finding agolmelatine, posted by kengwen on June 16, 2008, at 22:30:36
Agomelatine powder can probably be acquired from some chemical suppliers.
Unfortunately, mirtazapine, nefazodone, and cyproheptadine all block serotonin 5-HT2A rather than 5-HT2C receptors, so they can hardly emulate agomelatine. As far as I know, there is no reasonable choice for for a 5-HT2C antagonist on the official pharmaceutical market.
Posted by nothing on July 19, 2008, at 1:34:27
In reply to finding agolmelatine, posted by kengwen on June 16, 2008, at 22:30:36
heh... I read the outline for that 52week study with Agomelatine.. Honestly you really should've paced yourself by taking 1/2 the dose for the first half of the study, then lie/complain it wasn't working well enough then they might have upped your dose to 50mg, so then you'd have double the supply to pace yourself with which could've lasted more than enough to get you through to the approval date if that even occurs. Yea it seems wrong but truth is no one really cares about the discomfort you'll go through when you run out of the Ago as you're about to find out. If you don't fend for yourself no one will, after all they aren't the ones who are going to hurt and actually feel pain when your medication runs out. My guess is that EMEA's CHMP will prob approve Valdoxan this time around (last time it was rejected most likely bc of financial influences from investors for existing blockbuster pharmas like Lundbeck's Lexapro, after all, drugs with unexpired patents can still make money so if you're an investor why bother competing with yourself?) with sluggish FDA approval to follow about a half a year as it has to do its own useless investigation, in my estimate putting Agomelatine's USA release sometime around early 2009 (+/- a few months), if all goes perfectly. You should probably be thankful you were even lucky enough to get into that study. I tried hard to get in but research docs are b-holes and the criteria they must follow makes it almost impossible to get in, they seem to prefer females too. Just one more reason to dislike government bureaucracy and all these USELESS regulatory agencies. It makes me sick to my stomach that ritanserin very similar in functionality to agomelatine could make an afforable and effective add-on drug yet has no chance of ever being sold as a drug. Looks like you will have to wait like the rest of us. On the bright side, agomelatine may never be approved due to market pressure from existing drugs. Therefore, the discomfort you're likely about to feel won't be pointless. I don't mean to sound like a jerk, I can def sympathize AND empathize with what you must be going through right now. You probably just didn't know what to expect going into this study and now it has come to the end of the study and it's cut-off time. One thing that MIGHT help, but prob not too much. If Ago improved your sleep you may be able to substitute Ramelteon (Rozerem) for the time being. It won't have the antidepressant benefit but it may take the edge off anxiety and improve sleep regularity. However, this is def something to discuss with a pdoc rather than take my word. My guess is that going from Ago to Rozerem is likely to be somewhat of a letdown, but prob better than cold-turkey. This almost makes me glad I didn't get into the study as I wouldn't want the possibility of starting Ago, having to stop it, then restarting it up later only to find that it doesn't work the second time around. I really hope this doesn' turn out to be the case for you! Good luck and thanks for your contribution in getting Agomelatine approved for the rest of us! Hopefully that research center helped pay for your gas/parking during your checkup visits.
Posted by subconscious101 on August 11, 2008, at 3:56:41
In reply to finding agolmelatine, posted by kengwen on June 16, 2008, at 22:30:36
> HELP!! In 3 weeks my year will be over for my participation in a study group for Agomelatine. This has been the best medication to actually treat my severe depressive disorder. One year ago I was truly ready to give up. I had had enough. I participated under duress in one last clinical trial and l must say it saved my life. Agomelatine has been the only medication that has worked for me. Now my year is ending in a few weeks and I have been informed I can no longer receive this medication until FDA approval!! What am I supposed to do?? No SSRI has ever been effective for me and I cannot believe that my succes on Agomelitine will be suddenly stopped. I am scared to death (literally). Can anyone help me find where I can go to continue my medication regimine? Is it available anywhere?? HELP
Let me start by saying hello to everyone i am new here so greetings. I to have just completed a 12 week double blind study for Agomelatine and let me tell you this medication is NOTHING short or a miracle drug. Now saying that i know that all antidepressents react diffrent with diffrent people but i have tried over 20 medications and they have all been total crap!!!! At the end of the study when i was taken off i went through such a low period i didnt even want to live anymore ( It was hell) I to am also fighting doing evreything i can to get back on Agomelatine. My life changed drasticly i was able to sleep finaly for the first time in my life. My circadian rhythm became stable. Got off medical disability got a great job. I was finaly able to cry which i could never do being depressed for years and i became much more confedent and way less overwhelmed by anxitys. Now that i am off slowly i am slipping back to being blinded by the darkness makes me sick to be honest and it isnt fair. I NEED BACK ON IT I WOULD GIVE UP EVERYTHING THAT I HAVE!!!!!
Posted by Negcreep on August 11, 2008, at 4:58:45
In reply to Re: finding agolmelatine, posted by subconscious101 on August 11, 2008, at 3:56:41
> > HELP!! In 3 weeks my year will be over for my participation in a study group for Agomelatine. This has been the best medication to actually treat my severe depressive disorder. One year ago I was truly ready to give up. I had had enough. I participated under duress in one last clinical trial and l must say it saved my life. Agomelatine has been the only medication that has worked for me. Now my year is ending in a few weeks and I have been informed I can no longer receive this medication until FDA approval!! What am I supposed to do?? No SSRI has ever been effective for me and I cannot believe that my succes on Agomelitine will be suddenly stopped. I am scared to death (literally). Can anyone help me find where I can go to continue my medication regimine? Is it available anywhere?? HELP
>
> Let me start by saying hello to everyone i am new here so greetings. I to have just completed a 12 week double blind study for Agomelatine and let me tell you this medication is NOTHING short or a miracle drug. Now saying that i know that all antidepressents react diffrent with diffrent people but i have tried over 20 medications and they have all been total crap!!!! At the end of the study when i was taken off i went through such a low period i didnt even want to live anymore ( It was hell) I to am also fighting doing evreything i can to get back on Agomelatine. My life changed drasticly i was able to sleep finaly for the first time in my life. My circadian rhythm became stable. Got off medical disability got a great job. I was finaly able to cry which i could never do being depressed for years and i became much more confedent and way less overwhelmed by anxitys. Now that i am off slowly i am slipping back to being blinded by the darkness makes me sick to be honest and it isnt fair. I NEED BACK ON IT I WOULD GIVE UP EVERYTHING THAT I HAVE!!!!!<<Wow thats certainly a very positive report, and im very happy to read it.
Can you tell us anymore about your experience with the drug? Specifically Im looking for information on side effects. Ive read claims that agomelatine basically has no side effects(except for a bit of dizziness in the first week), is this accurrate?
Also is the claim of no sexual side effects also true?Thanks for sharing your experience so far, I look forward to hearing more from you and others :)
Neg
Posted by Marty on August 11, 2008, at 8:17:05
In reply to Re: finding agolmelatine, posted by Negcreep on August 11, 2008, at 4:58:45
Wow.. It certainly raise my hope of finding the good med for me when I hear both of you describe this drug as that good compare to all the others you tried !I feel sorry for you and I imagine what it would feels like to be in your situation. Isn't there any special program in the US where you can ask for a special treatment and receive this med directly from the company until the FDA approves it ?
I think usually the criterion in this circomstance are: 1.Your illness must be potentially fatal. 2. Nothing else worked.
I do think it fits these criterion in the sense that your depression are potentially fatal. You would both have to have a backrecord of failure on meds, which I think you both have, right ?
I think you should post a new thread and ask the people here familliar with this kind of special program.
Good luck!
/\/\arty
Posted by Marty on August 11, 2008, at 9:45:56
In reply to Re: finding agolmelatine » Negcreep, posted by Marty on August 11, 2008, at 8:17:05
I just realized the naivety of my last post. I'm sure you and your pdoc already look into it. Sorry, I was just getting out of the bed when I post this and hadn't my mind awake enough to see the pointlessness of my intervention.Keep us posted,
/\/\arty
Posted by desolationrower on August 11, 2008, at 18:13:47
In reply to Re: finding agolmelatine » Marty, posted by Marty on August 11, 2008, at 9:45:56
If you can't find it, you could consider low dose of ziprasidone and melatonin.
Posted by subconscious101 on August 12, 2008, at 4:00:33
In reply to Re: finding agolmelatine, posted by Negcreep on August 11, 2008, at 4:58:45
To answer Negcreep's question about side effects. I had trouble sleeping the first 3 nights that is it!!! Nothing else no sexual side effects no wieght gain no nothing. Infact i lost 6 pounds being on agolmelatine. And noticed my eating patterns getting better probably because i didn't need food for comfort as much anymore. I can't honestly say enough good stuff about this medication. Anyone have any suggestions on how i may get back on this mediction. My docter has tried calling wherever the main place is twice and each time been denied due to the fact it hasn't been released anywhere else in the world. Also anyone know any new info about when this drug is going to be approved in any country??
Posted by Negcreep on August 12, 2008, at 6:03:16
In reply to Re: finding agolmelatine, posted by subconscious101 on August 12, 2008, at 4:00:33
> To answer Negcreep's question about side effects. I had trouble sleeping the first 3 nights that is it!!! Nothing else no sexual side effects no wieght gain no nothing. Infact i lost 6 pounds being on agolmelatine. And noticed my eating patterns getting better probably because i didn't need food for comfort as much anymore. I can't honestly say enough good stuff about this medication. Anyone have any suggestions on how i may get back on this mediction. My docter has tried calling wherever the main place is twice and each time been denied due to the fact it hasn't been released anywhere else in the world. Also anyone know any new info about when this drug is going to be approved in any country??
Thanks for getting back to me on that one. Im really glad that for you the drug has lived up to its hype. Im really looking forward to getting hold of this stuff here in the UK as ive suffered with GAD and depression for 10 years now.
I added some info the the wiki for Agomelatine a few months ago and its still true now.
http://en.wikipedia.org/wiki/AgomelatineWe're looking at a 2008/9 approval in the UK and Europe (assuming it gets positive opinion). In the US, Novartis should submit a New drug application (NDA) to the FDA by the end of this year. So can be expected in late 2009/10 over the pond. That is of course assuming they let it through. But considering the latest research and these positve reports im hearing , I dont see how they could not.
Thanks youve given me some hope for the future :)
Neg
Posted by Marty on August 12, 2008, at 16:17:28
In reply to Re: finding agolmelatine, posted by desolationrower on August 11, 2008, at 18:13:47
> If you can't find it, you could consider low dose of ziprasidone and melatonin.
---
While I see why to think it could emulate somehow Agomelatine, I really doubt it would in any way feels like Agomelatine. But maybe there's something you see there that I don't: 5-HT2C antagonism + Melatonin receptor agonism. I thinks it's oversimplistic but, like everything else in this Trial/Error pills game, who knows?/\/\arty
Posted by Marty on August 12, 2008, at 17:21:23
In reply to Re: finding agolmelatine, posted by Negcreep on August 12, 2008, at 6:03:16
Thank you for the hope! Can anyone tells me how it felt compared to the other antidepressant classes ? Does it feel like an anxiolitic SSRI but without the side effect ? Is one part of the feeling reminiscent of the 'atypical' light antidepressant effect induce by some atypical antipsychotic, lets say Seroquel ? And what about the cognitive side effects (Memory, attention, organisational skills) and motivation ?Can't believe something that good is comming on the market after all those years! ... don't count on me to wait for the FDA to approve it here in America. The minute it's in the UK -> Hello offshore order !
/\/\arty
Posted by Negcreep on August 15, 2008, at 8:59:25
In reply to Re: finding agolmelatine » desolationrower, posted by Marty on August 12, 2008, at 16:17:28
> > If you can't find it, you could consider low dose of ziprasidone and melatonin.
> ---
> While I see why to think it could emulate somehow Agomelatine, I really doubt it would in any way feels like Agomelatine. But maybe there's something you see there that I don't: 5-HT2C antagonism + Melatonin receptor agonism. I thinks it's oversimplistic but, like everything else in this Trial/Error pills game, who knows?
>
> /\/\arty
>Yeah I agree with Marty. To be honest Id give it up trying to find combinations of other drugs to approximate the effect of Agomelatine. Its a totally new mechanism of action, and poly-pharmacy will usually just increase unwanted side effects.
Also it seems as though getting hold of this drug before its approved will be next to impossible. Im not saying its not worth trying, but dont get your hopes up. Id say the best bet is think back through everything youve tried so far and find something that helps and has bearable side effects (trying to get by on a lower dose could help too) then just hold out untill this agomelatine is released.It sucks but we're just gonna have to be patient.
Neg
Posted by Marty on August 15, 2008, at 11:53:13
In reply to Re: finding agolmelatine » Marty, posted by Negcreep on August 15, 2008, at 8:59:25
> Yeah I agree with Marty. To be honest Id give it up trying to find combinations of other drugs to approximate the effect of Agomelatine. Its a totally new mechanism of action, and poly-pharmacy will usually just increase unwanted side effects.
---
Exactly. and we dont' even start talking about the fact that what we know about the mechanism of action of a drug is very often suspected to be simplistic in theory and more complex in practice; many years from now we could find that Agomelatine act also on another familly of receptor/transporter/second messenger etc etc... You can't emulate a drug that you don't know well enough. Damn... even SSRI between them aren't often interchangeable depending of your condition. If Celexa can't emulate Paxil and Paxil can't emulate Prozac .. good luck emulating Agomelatine with a strong and dull atypical antipsychotic + the only other med that you know interact with Melatonin Receptors beside Agomelatine!> Also it seems as though getting hold of this drug before its approved will be next to impossible. Im not saying its not worth trying, but dont get your hopes up. Id say the best bet is think back through everything youve tried so far and find something that helps and has bearable side effects (trying to get by on a lower dose could help too) then just hold out untill this agomelatine is released.
>
> It sucks but we're just gonna have to be patient.
---
Did I read well about the possibility that Agomelatine approval in Europe could be in September 2008 ? I'm waiting for something like this since 16 years with intensive trial since 10 years... I, for one, can wait another couple months! .. but I know it's not the case for everyone and I feel sorry for them./\/\arty
Posted by NegCreep on August 15, 2008, at 12:24:20
In reply to Re: finding agolmelatine » Negcreep, posted by Marty on August 15, 2008, at 11:53:13
Yeah the rumour is that its very very close to 'opinion' from the EMEA in europe. I know from reading all this stuff for the past 6 months that agomelatine was submitted sometime last summer (before november anyway). The usual EMEA turnaround time for a drug from submission to opinion is about 1 year. Then its anyones guess to how long it takes the drug to hit the market. Id say 2-6 months is a good estimate. This is the second time around after a failed attmept in 2006, so much of what they are reviewing would be covering old ground. It is very possible that it could make it out before christmas.
Now that would be a nice christmas present eh :)
Posted by Marty on August 15, 2008, at 14:43:25
In reply to Re: finding agolmelatine » Marty, posted by NegCreep on August 15, 2008, at 12:24:20
> Now that would be a nice christmas present eh :)
---
Epic one.
Best ever. :PThanks for all the info. I've just created a new thread to ask people who tried it to be more specific about the effect of Agomelatine compared to other ADs tried by those people. I asked questions on this thread to those persons but didn't get answers... if you know some URLs of other thread in this forum or other forums which relate some experience with Agomelatine that would be great to compiled them in a post of that thread for everyone to see.
Later fellow Agomelatine believer,
/\/\arty
Posted by subconscious101 on August 19, 2008, at 5:38:50
In reply to finding agolmelatine, posted by kengwen on June 16, 2008, at 22:30:36
Hey kengwen i was just wondering if you had experienced any withdrawl symptoms from being on agolmelatine ? If so i was wondering if you could share them with me. Also where do you live ? I would like to get in contact with you through e-mail if possible to talk more in depth.
- Cheers
Posted by Marty on August 19, 2008, at 9:27:07
In reply to Re: finding agolmelatine, posted by subconscious101 on August 19, 2008, at 5:38:50
> Hey kengwen i was just wondering if you had experienced any withdrawl symptoms from being on agolmelatine ? If so i was wondering if you could share them with me. Also where do you live ? I would like to get in contact with you through e-mail if possible to talk more in depth.
---
Hi Sub,I hope Kengwen will answer you. Meanwhile could you describe Agomelatine more in depth ? I'd like to know how you would compare the general 'feeling' to other antidepressant you tried. Of special interest to me is the cognitive and motivation side. Serotonergic usually 'dumb' me too much for my taste.. like some brain fog. Also usually SSRIs kills your motivation. I ask you to compare to other ADs because to evaluate of Agomelatine differ from other ADs I need to know how you usually felt on other ADs.
If you can take 2 minutes to answers me I'll be very appreciative! ... finding people who tried Agomelatine is pretty hard as you would guess.
Thanks!
/\/\arty
Posted by subconscious101 on August 19, 2008, at 15:22:43
In reply to Re: finding agolmelatine, posted by subconscious101 on August 19, 2008, at 5:38:50
Hi Sub,
I hope Kengwen will answer you. Meanwhile could you describe Agomelatine more in depth ? I'd like to know how you would compare the general 'feeling' to other antidepressant you tried. Of special interest to me is the cognitive and motivation side. Serotonergic usually 'dumb' me too much for my taste.. like some brain fog. Also usually SSRIs kills your motivation. I ask you to compare to other ADs because to evaluate of Agomelatine differ from other ADs I need to know how you usually felt on other ADs.
If you can take 2 minutes to answers me I'll be very appreciative! ... finding people who tried Agomelatine is pretty hard as you would guess.
Thanks!
/\/\artyYes marty i empathize with you not being able to find many people who had the chance to experience agolmelatine. In response to your questions i will try and do my best.
1) I'd like to know how you would compare the general 'feeling' to other antidepressant you tried -
Agolmelatine was different in that it did not make me feel strange being on it. Like you know how you can kinda feel other antidepressents well agolmelatine was very suttle and very smooth. It was very helpful in helping me sleep and i was able to enjoy working a job again. Compared to other ssri's agolmelatine was a better all around antidepressent meaning that it wasent just good for depression it helped me in alot of other ways AD's could not. It realy just balanced me out. In all i would just say that compared to other ssri's i did not have the side effects and actualy did a much better job. Other antidepressents all had bad side effects that outweighed the benifits of the medication.
2) As for the cognitive and motivational side that is where agolmelatine realy shined for me it changed the way i was thinking and did not dwell on things that didn't matter to me anymore. I was more confident and for once was thinking from the heart more and not so much out of anger. I hope this has been helpfull for you - take care
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