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Re: finding agolmelatine » johnj

Posted by jrbecker76 on June 22, 2008, at 10:47:31

In reply to Re: finding agolmelatine » jrbecker76, posted by johnj on June 21, 2008, at 12:42:47

> May I ask what is your dose of cymbalta and serzone as you said you take low doses. Is this combination helpful for sleep and anxiety? Do you take low doses because of med sensitivity (that is my problme).
>
> regards
>
> johnj

John-

I don't suffer from any OCD symptology, so I can't necessarily comment on its impact, however, agomelatine did have slight anxiolytic qualities.

As for my Cymbalta/Nefazodone, I have gone anywhere from 5-10 mg of Cymbalta together with 10-50mg of Nefazodone. Currently, I am on a dose of 7.5mg of Cymbalta combined with 10 mg of Nefazodone. As you guessed, I am very med-sensitive. I exhibit atypical features, and most likely would fall within a soft bipolar diagnosis.

The low-dose Nefazodone is a great off-setter to SSRI/SNRI side effects. It helps as a hypnotic, mild antidepressant/anxiolytic and adds even mood-stabilizing properties. It of course has its own side effects, but are typically less averse at lower doses. And despite the concerns of liver toxicity that were covered a few years ago, I still believe that the issue is minor when using lower doses and monitored properly.

A person suffering from treatment-resistant depression who might be looking to explore an add-on AP (e.g., Risperdal, Seroquel) should perhaps trial Nefazodone first.

When the newer class of 5-HT2a antagonist sleep agents reach market, I would consider trading in the Nefazodone for a compound with better selectivity.


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