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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Sheilac on October 29, 2007, at 10:51:14
I am wondering what brain chemicals are effected by low dose prozac and seroquel?
I'm hoping to try prozac again - we'll see if it bothers my bladder. And also some seroquel at night to sleep. Right now I am not sleeping and I am very depressed.
I also think that maybe the seroquel would act as a mood stabilizer to the prozac?
Posted by Phillipa on October 29, 2007, at 11:49:43
In reply to Seroquel/Prozac combo?, posted by Sheilac on October 29, 2007, at 10:51:14
Good possibility see my response to your thread above not incinuating you have interstitial bladder but a thought? Phillipa
Posted by yxibow on October 30, 2007, at 11:43:51
In reply to Seroquel/Prozac combo?, posted by Sheilac on October 29, 2007, at 10:51:14
> I am wondering what brain chemicals are effected by low dose prozac and seroquel?
>
> I'm hoping to try prozac again - we'll see if it bothers my bladder. And also some seroquel at night to sleep. Right now I am not sleeping and I am very depressed.
>
> I also think that maybe the seroquel would act as a mood stabilizer to the prozac?Prozac: reuptake of serotonin across multiple transmitters (5HTx)
Seroquel: antagonist / blockade of the following
5HT (serotonin) mainly at 5HT1A, 5HT2, D1 (dopamine) and D2, majorly at H1 (histamine) and a1 and a2 (adrenergic) as a byproduct responsible for its sleepymaking, minorly at 5HT3 as all antipsychotics (antiemetic)
Posted by SheilaC on October 30, 2007, at 12:11:03
In reply to Re: Seroquel/Prozac combo? » Sheilac, posted by yxibow on October 30, 2007, at 11:43:51
> > I am wondering what brain chemicals are effected by low dose prozac and seroquel?
> >
> > I'm hoping to try prozac again - we'll see if it bothers my bladder. And also some seroquel at night to sleep. Right now I am not sleeping and I am very depressed.
> >
> > I also think that maybe the seroquel would act as a mood stabilizer to the prozac?
>
> Prozac: reuptake of serotonin across multiple transmitters (5HTx)
>
> Seroquel: antagonist / blockade of the following
>
> 5HT (serotonin) mainly at 5HT1A, 5HT2, D1 (dopamine) and D2, majorly at H1 (histamine) and a1 and a2 (adrenergic) as a byproduct responsible for its sleepymaking, minorly at 5HT3 as all antipsychotics (antiemetic)
>
So does Prozac and Seroquel counter each other? 50mg. of Seroquel really helps me sleep and I can get by on only 10mg. of Prozac.
Posted by Larry Hoover on October 30, 2007, at 12:36:07
In reply to Seroquel/Prozac combo?, posted by Sheilac on October 29, 2007, at 10:51:14
> I am wondering what brain chemicals are effected by low dose prozac and seroquel?
>
> I'm hoping to try prozac again - we'll see if it bothers my bladder. And also some seroquel at night to sleep. Right now I am not sleeping and I am very depressed.
>
> I also think that maybe the seroquel would act as a mood stabilizer to the prozac?Well, the combination is believed to be sufficiently complementary, that it is marketed as Symbyax. See:http://www.rxlist.com/cgi/generic/symbyax.htm
What I don't like about Symbyax is that the proportions of the relevent meds are fixed. You have far greater flexibility if you titrate each drug separately.
Lar
Posted by yxibow on October 31, 2007, at 0:16:21
In reply to Re: Seroquel/Prozac combo? » Sheilac, posted by Larry Hoover on October 30, 2007, at 12:36:07
> > I am wondering what brain chemicals are effected by low dose prozac and seroquel?
> >
> > I'm hoping to try prozac again - we'll see if it bothers my bladder. And also some seroquel at night to sleep. Right now I am not sleeping and I am very depressed.
> >
> > I also think that maybe the seroquel would act as a mood stabilizer to the prozac?
>
> Well, the combination is believed to be sufficiently complementary, that it is marketed as Symbyax. See:http://www.rxlist.com/cgi/generic/symbyax.htm
>
> What I don't like about Symbyax is that the proportions of the relevent meds are fixed. You have far greater flexibility if you titrate each drug separately.
>
> LarExactly. It leaves much to be desired.
Yes, they're complementary, especially in treatment resistant OCD, e.g. Not without their own side effects of course -- polypharmacy should ideally be done by someone who knows how to combine medications effectively
Posted by Astounder on October 31, 2007, at 17:32:54
In reply to Re: Seroquel/Prozac combo?, posted by SheilaC on October 30, 2007, at 12:11:03
> > > I am wondering what brain chemicals are effected by low dose prozac and seroquel?
> > >
> > > I'm hoping to try prozac again - we'll see if it bothers my bladder. And also some seroquel at night to sleep. Right now I am not sleeping and I am very depressed.
> > >
> > > I also think that maybe the seroquel would act as a mood stabilizer to the prozac?
> >
> > Prozac: reuptake of serotonin across multiple transmitters (5HTx)
> >
> > Seroquel: antagonist / blockade of the following
> >
> > 5HT (serotonin) mainly at 5HT1A, 5HT2, D1 (dopamine) and D2, majorly at H1 (histamine) and a1 and a2 (adrenergic) as a byproduct responsible for its sleepymaking, minorly at 5HT3 as all antipsychotics (antiemetic)
> >
>
>
> So does Prozac and Seroquel counter each other? 50mg. of Seroquel really helps me sleep and I can get by on only 10mg. of Prozac.
>
They don't counter each other. At that dose, it's only going to be acting as a sedative (H1 blocking, alpha1 blocking). The alpha2 blocking could have adjunctive antidepressant effects by disinhibiting serotonergic neurons, but Seroquel's 6 hr half-life means it won't be around in the daytime. The only other thing it does at that dose is block 5-HT6, which is anxiolytic in animal models and might help you get to bed easier.
This is the end of the thread.
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