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Re: Seroquel/Prozac combo? » SheilaC

Posted by Astounder on October 31, 2007, at 17:32:54

In reply to Re: Seroquel/Prozac combo?, posted by SheilaC on October 30, 2007, at 12:11:03

> > > I am wondering what brain chemicals are effected by low dose prozac and seroquel?
> > >
> > > I'm hoping to try prozac again - we'll see if it bothers my bladder. And also some seroquel at night to sleep. Right now I am not sleeping and I am very depressed.
> > >
> > > I also think that maybe the seroquel would act as a mood stabilizer to the prozac?
> >
> > Prozac: reuptake of serotonin across multiple transmitters (5HTx)
> >
> > Seroquel: antagonist / blockade of the following
> >
> > 5HT (serotonin) mainly at 5HT1A, 5HT2, D1 (dopamine) and D2, majorly at H1 (histamine) and a1 and a2 (adrenergic) as a byproduct responsible for its sleepymaking, minorly at 5HT3 as all antipsychotics (antiemetic)
> >
>
>
> So does Prozac and Seroquel counter each other? 50mg. of Seroquel really helps me sleep and I can get by on only 10mg. of Prozac.
>


They don't counter each other. At that dose, it's only going to be acting as a sedative (H1 blocking, alpha1 blocking). The alpha2 blocking could have adjunctive antidepressant effects by disinhibiting serotonergic neurons, but Seroquel's 6 hr half-life means it won't be around in the daytime. The only other thing it does at that dose is block 5-HT6, which is anxiolytic in animal models and might help you get to bed easier.


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