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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by saturn on January 29, 2007, at 12:40:35
My understanding is that Remeron has three basic modes of action: alpha-1 antagonism, histamine antagonism and 5-HT1&3 antagonism.
Can anyone compare these effects both theoretically and practically/clinically at 7.5, 15 and 30 mg?
Is 7.5 less or more sedating than 15 mg?
Will one receive an antidepressant effect at 7.5 or 15 mg?
Thanks...Peace...Saturn
Posted by dbc on January 29, 2007, at 13:39:40
In reply to Comparing Remeron at 7.5, 15 and 30mg (question), posted by saturn on January 29, 2007, at 12:40:35
I couldnt tell a difference between 7.5 and 15 to tell you the truth. They both simply put me in a coma like sleep for 12 hours. 30 is really when it started being effective as an an anxiolytic and anti-depressant.
Posted by blueberry1 on January 29, 2007, at 13:47:34
In reply to Comparing Remeron at 7.5, 15 and 30mg (question), posted by saturn on January 29, 2007, at 12:40:35
Good question. Since mileage varies so much, it is hard to give a universal answer. I can share my experience though.
7.5mg and 15mg felt similar. 15mg maybe more sedating.
7.5mg brought immediate calm. It also increased the loudness of my tinnitus. After 3 days I was feeling some nervousness that hadn't been there before, or actually a different kind of nervousness than I had. I could tell from these things that I was getting too much noradrenalin action even at just 7.5mg. I tried 3.125mg a few times and did not get the increased tinnitus, but did get the sedation, so I think that dose is below the adrenergic part.
Some people claim the higher doses are less sedating. Other people say the higher doses were like be shot with an elephant dart. Everyone reacts different. For me the higher doses just left me too foggy the next day.
Posted by Iansf on January 29, 2007, at 18:02:45
In reply to Re: Comparing Remeron at 7.5, 15 and 30mg (questio, posted by dbc on January 29, 2007, at 13:39:40
> I couldnt tell a difference between 7.5 and 15 to tell you the truth. They both simply put me in a coma like sleep for 12 hours. 30 is really when it started being effective as an an anxiolytic and anti-depressant.
Does this mean 30mg DIDN'T put you in a coma-like sleep?
Posted by dbc on January 29, 2007, at 18:26:32
In reply to Re: Comparing Remeron at 7.5, 15 and 30mg (questio » dbc, posted by Iansf on January 29, 2007, at 18:02:45
> Does this mean 30mg DIDN'T put you in a coma-like sleep?
>30 seemed less sedating but my analysis could be flawed since i was on 150mg of effexor at the time also.
Posted by dbc on January 29, 2007, at 18:27:35
In reply to Re: Comparing Remeron at 7.5, 15 and 30mg (questio, posted by dbc on January 29, 2007, at 18:26:32
I should clarify, sedating in the anti-histamine knock you out sense not the anxiolytic sense.
Posted by flmm on January 29, 2007, at 20:31:17
In reply to Re: Comparing Remeron at 7.5, 15 and 30mg (questio, posted by dbc on January 29, 2007, at 18:27:35
Tried 15 mg one night. So drugged, drunk feeling the next day at work there was no way I could take it again. Most knocked out I ever felt. Did not like!......................
Posted by JayBTV on January 30, 2007, at 9:24:55
In reply to Re: Comparing Remeron at 7.5, 15 and 30mg (questio, posted by flmm on January 29, 2007, at 20:31:17
I started at 15mg for 2weeks then jumped to 30mg. Was definitely sedated the first two weeks (Re: 10-12hr nights and a few naps). However it did get better as the time went on.
I'm currently on my second week of 30mg and sedation isn't a problem for me anymore. After the dose I'm definitely knocked out but I don't feel as though it's effecting me energy wise during the day. The munchies have also abated a good deal.
The only other med I'm currently on is Lithium (1200mg / .8 level). As a combo I'm feeling much better than I have in a long time (last trial was Neurontin + Tricyclics + Concerta + Lithium which sent me way out of my head). I still do have some strange existential thoughts every now and again but at least I'm motivated and happy. IMO the Remeron deserves the credit for the positive affect. Hopefully it'll keep working for me....
Cheers,
-Jay
Posted by dbc on January 30, 2007, at 13:17:24
In reply to Re: Comparing Remeron at 7.5, 15 and 30mg (questio, posted by JayBTV on January 30, 2007, at 9:24:55
It really is a great drug if you can make it through the first 2 weeks - month. Its too bad 90% of people cant.
Posted by yxibow on February 2, 2007, at 23:22:58
In reply to Comparing Remeron at 7.5, 15 and 30mg (question), posted by saturn on January 29, 2007, at 12:40:35
> My understanding is that Remeron has three basic modes of action: alpha-1 antagonism, histamine antagonism and 5-HT1&3 antagonism.
>
> Can anyone compare these effects both theoretically and practically/clinically at 7.5, 15 and 30 mg?
>
> Is 7.5 less or more sedating than 15 mg?
>
> Will one receive an antidepressant effect at 7.5 or 15 mg?
7.5mg is just as sedating as 15mg and is just as weight inducing more unfortunately as well frankly all dosages that I have been on, including 52.5mg. This has been the general results of patients my doctor has seen but others could theoretically see different, of course, as a disclaimer.One will probably receive a greater small effect of 5HT at 15mg but doesn't really activate that side of things until around 30mg. But I do believe that it makes a different at clinically high doses that the alpha site is not doing alone, sort of like a neuroleptic but no dopaminergic action.
Posted by saturn on February 8, 2007, at 0:03:17
In reply to Re: Remeron, posted by dbc on January 30, 2007, at 13:17:24
> It really is a great drug if you can make it through the first 2 weeks - month. Its too bad 90% of people cant.
dbc,
May I ask if you've had personal experience with Remeron (and if so what it was/is)? Thanks...Peace...Saturn.
This is the end of the thread.
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