![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by Marty on April 23, 2006, at 23:10:42
Marty's here with another issue with starting Parnate ..I've scaled down my dose to 5mg for 1 week to see if my system would adapt to the drug, stoping to mess with my BP. And so today was my first 5mg dose.
Is someone aware of some people being agressive while being on Parnate ? I hadn`t been able to retain my self, control my self today when my girlfriend told me something that pissed me a little.. I`ve try to not start a (verbal) fight, I was even aware that it was the Parnate that induced me that agressivity.. but still.. after trying 2 minutes.. I've done it.. started to give her crap about the issue and many other things.. whatever..
I don't have any agressivity problem normally.
Today Parnate gave me 4 feelings:
1. Sleepy
2. Dazed
3. Emotional (sometimes tears for NOTHING)
4. Agressivity.. Any experiences, ideas or comments would be greatly appreciated..
before I start to desaspear..
Marty
Posted by willyee on April 24, 2006, at 6:03:17
In reply to Agressivity on 5mg of PARNATE, uh help?, posted by Marty on April 23, 2006, at 23:10:42
Parnate is encetric coated,made to swallow the entire tab,breaking allows fillers etc to be swallowed.Porb not recomended although of course i have and it goes great with certain sedatives.
Trying adding a mild sedative to the 5 mg.
Posted by MARTY on April 24, 2006, at 12:20:40
In reply to Re: Agressivity on 5mg of PARNATE, uh help?, posted by willyee on April 24, 2006, at 6:03:17
> Parnate is encetric coated,made to swallow the entire tab,breaking allows fillers etc to be swallowed.Porb not recomended although of course i have and it goes great with certain sedatives.
I don't think so, but are you thinking that my agressive/rageous temper could be caused by cutting my pill ? But hey, why not consider the impossible.. that's what hopeless is for.
Marty
> Trying adding a mild sedative to the 5 mg.
Posted by Crazy Horse on April 24, 2006, at 13:06:51
In reply to Agressivity on 5mg of PARNATE, uh help?, posted by Marty on April 23, 2006, at 23:10:42
>
> Marty's here with another issue with starting Parnate ..
>
> I've scaled down my dose to 5mg for 1 week to see if my system would adapt to the drug, stoping to mess with my BP. And so today was my first 5mg dose.
>
> Is someone aware of some people being agressive while being on Parnate ? I hadn`t been able to retain my self, control my self today when my girlfriend told me something that pissed me a little.. I`ve try to not start a (verbal) fight, I was even aware that it was the Parnate that induced me that agressivity.. but still.. after trying 2 minutes.. I've done it.. started to give her crap about the issue and many other things.. whatever..
>
> I don't have any agressivity problem normally.
>
> Today Parnate gave me 4 feelings:
> 1. Sleepy
> 2. Dazed
> 3. Emotional (sometimes tears for NOTHING)
> 4. Agressivity
>
> .. Any experiences, ideas or comments would be greatly appreciated..
>
> before I start to desaspear..
>
> MartyMarty, Marty, Marty, What am i going do with you?? 5mgs. made you aggressive?? You are a sensitive young man, eh? Are you normally super sensitive to medications?
Just a thought...please don't get pissed :) Perhaps you are imagining, or over analyzing things. Maybe you were just having a bad morning...and it had nothing to do with the Parnate?? You have been under A LOT of stress lately..you are intitled to a bad mood you know. I could be wrong..but i really doubt your first dose of only 5mgs is going to do much of anything.
Marty, I just don't want you to "Psych yourself" out of a good trial on Parnate. Because if it does work for you, it could change your whole life! You know i'm only trying to help, okay? And if Parnate isn't the right med for you i am still going to be your friend and support and help you in any way i can. :)
Another thought, maybe it's still withdrawal from Nardil. Your brain is going through a lot of chemical changes, going off Nardil, on Parnate for a few Days, off Parnate, Now back on Parnate....plus you didn't sleep for awhile, see what i'm saying Marty??...it could be a combination of all of the above. Hang in there Bud, try to relax..take some Klonopin :)
Oh yea, the crying part...simple, you are becoming a woman!!! (just kidding of course). :) Again, you've been through a lot, and your brain has been through a lot of changes in the last 2 weeks. Hang tough my friend, and seriously take some Klonopin.
Monte
Posted by ed_uk on April 24, 2006, at 13:33:45
In reply to Agressivity on 5mg of PARNATE, uh help?, posted by Marty on April 23, 2006, at 23:10:42
Hi Marty,
Perhaps you should stop Parnate and try again in 1-2 weeks. It's quite possible that the Nardil may still be having 'residual' effects.
You could start with 5mg in the morning......carefully monitoring your BP.
Ed
Posted by Crazy Horse on April 24, 2006, at 13:42:38
In reply to Re: Agressivity on 5mg of PARNATE, uh help? » Marty, posted by Crazy Horse on April 24, 2006, at 13:06:51
> >
> > Marty's here with another issue with starting Parnate ..
> >
> > I've scaled down my dose to 5mg for 1 week to see if my system would adapt to the drug, stoping to mess with my BP. And so today was my first 5mg dose.
> >
> > Is someone aware of some people being agressive while being on Parnate ? I hadn`t been able to retain my self, control my self today when my girlfriend told me something that pissed me a little.. I`ve try to not start a (verbal) fight, I was even aware that it was the Parnate that induced me that agressivity.. but still.. after trying 2 minutes.. I've done it.. started to give her crap about the issue and many other things.. whatever..
> >
> > I don't have any agressivity problem normally.
> >
> > Today Parnate gave me 4 feelings:
> > 1. Sleepy
> > 2. Dazed
> > 3. Emotional (sometimes tears for NOTHING)
> > 4. Agressivity
> >
> > .. Any experiences, ideas or comments would be greatly appreciated..
> >
> > before I start to desaspear..
> >
> > Marty
>
> Marty, Marty, Marty, What am i going do with you?? 5mgs. made you aggressive?? You are a sensitive young man, eh? Are you normally super sensitive to medications?
>
> Just a thought...please don't get pissed :) Perhaps you are imagining, or over analyzing things. Maybe you were just having a bad morning...and it had nothing to do with the Parnate?? You have been under A LOT of stress lately..you are intitled to a bad mood you know. I could be wrong..but i really doubt your first dose of only 5mgs is going to do much of anything.
>
> Marty, I just don't want you to "Psych yourself" out of a good trial on Parnate. Because if it does work for you, it could change your whole life! You know i'm only trying to help, okay? And if Parnate isn't the right med for you i am still going to be your friend and support and help you in any way i can. :)
>
> Another thought, maybe it's still withdrawal from Nardil. Your brain is going through a lot of chemical changes, going off Nardil, on Parnate for a few Days, off Parnate, Now back on Parnate....plus you didn't sleep for awhile, see what i'm saying Marty??...it could be a combination of all of the above. Hang in there Bud, try to relax..take some Klonopin :)
>
> Oh yea, the crying part...simple, you are becoming a woman!!! (just kidding of course). :) Again, you've been through a lot, and your brain has been through a lot of changes in the last 2 weeks. Hang tough my friend, and seriously take some Klonopin.
>
> MonteMarty,
I hope my above post didn't upset you in any way. I know you are frustrated...i am also frustrated for you. But the last thing i want to do is hurt your feelings...i just want what's best for you bud, so you and Annie can be Happy together and of course "relax together." :) You're are my best bud in here, and i'm sorry if i said anything to upset you..okay? Things will get better soon my friend! I continue to pray for you every day.Monte ..The frustrated Crazy Horse Man :)
Posted by MARTY on April 24, 2006, at 14:41:16
In reply to Re: Agressivity on 5mg of PARNATE, uh help? » Marty, posted by Crazy Horse on April 24, 2006, at 13:06:51
Hi CH> Marty, Marty, Marty, What am i going do with you?? 5mgs. made you aggressive?? You are a sensitive young man, eh? Are you normally super sensitive to medications?
What are you going to do with me ? I don't know Horse, if I give you my carrot would you give me a ride ? LOLLL uh.. kidding?
In fact I ALWAYS have been SUPER EXTRA MEGA GIGA sensitive on medications. Always had rare or even unheard of side effects. But well, because I do anxiety not many doc believe in some of those effect. It's even a running gag between my Pdoc and me.. I can come back to her office with some strong/rare/unheard of side effects even on the smallest dose. Example is my facial "electric/fire wave of pain" caused by Risperdal - 0.5mg!
> Just a thought...please don't get pissed :) Perhaps you are imagining, or over analyzing things. Maybe you were just having a bad morning...and it had nothing to do with the Parnate?? You have been under A LOT of stress lately..you are intitled to a bad mood you know. I could be wrong..but i really doubt your first dose of only 5mgs is going to do much of anything.
Bad day, nah.. the feeling was very strong and uncommon. I could have run myself into trouble just to have some faces to punch, and believe me.. I, like most people, hate violence. I'm a pacifist and I always believe in respect, communication and empathy. I feeled like a warrior who had to find something to fight. I was irritable without end.
> Marty, I just don't want you to "Psych yourself" out of a good trial on Parnate. Because if it does work for you, it could change your whole life! You know i'm only trying to help, okay? And if Parnate isn't the right med for you i am still going to be your friend and support and help you in any way i can. :)
I doubt we could stay friends after a Parnate failure: you will be jealous of Annie and me of your Parnate. It could never works ;)= ahahI will continue Parnate as long as I can. Yerterday after the biggest fight ever with my girlfriend, I asked her if she wanted me to continue or stop.. because she has been/could be the one to suffer the most from my destructive mood. And she told me I had to continue whatever happens. She's with me. As long as it's the case I'll continue my quest for Parnate.
> Another thought, maybe it's still withdrawal from Nardil. Your brain is going through a lot of chemical changes, going off Nardil, on Parnate for a few Days, off Parnate, Now back on Parnate....plus you didn't sleep for awhile, see what i'm saying Marty??...it could be a combination of all of the above. Hang in there Bud, try to relax..take some Klonopin :)
You're right, lots of change in the dynamic of my brain lately. It AT LEAST contribute to all this for sure.I may be very sensible at some dopamine receptors in some part of my brain:
- Think Wellbutrin made me like that at a lower level.
- Nardil, less dopaminergic, render me much more agressive than usually. All my familly agree on that.
- Risperdal, dopamine antagonist, even in very small dose give me big effect, side effects, one not even in case report.
-Social Phobic are believe to have some anormalities at the dopamine level; and they tend to respond badly to dopaminergic agent (anxiety)
-Social Phobic has 5x chances of having parkinson
-I'm walking very funny but when I drop my Acetylcholine to favor dopamine I start to walk very normally, can't even fake the way I walk usually LOL (yeah, yeah I know it all in my head)Sorry, not overanalyzing, just having fun :)
Btw, I WAS ON KLONOPIN yesterday. I don't want to take too much of it, it's depressing me relatively quickly. I'll ask my Pdoc for another benzo (Xanax would be good, but she don't like it).
> Oh yea, the crying part...simple, you are becoming a woman!!! (just kidding of course). :) Again, you've been through a lot, and your brain has been through a lot of changes in the last 2 weeks. Hang tough my friend, and seriously take some Klonopin.I was definitively crying often on Wellbutrin, memories coming back about it.
I'll talk about benzos with my Pdoc but will also as her if my reaction, my unstable and extremist (tears <-> rage) mood could be relate to my Bipolarity.. if yes, maybe it could be time to tweak a little more my "flatners" stabilizers ..
>Monte
Great name :) (I feel the need to comment everything, sorry)Thanks for your help Monte.. hope you know all the difference it does for me.. and others you help.
Marty
Posted by MARTY on April 24, 2006, at 14:53:08
In reply to Re: Agressivity on 5mg of PARNATE, uh help? » Crazy Horse, posted by Crazy Horse on April 24, 2006, at 13:42:38
Hey bud, relax! :P I'm not that agressive.. BTW, your windows firewall is pretty weak and your porn pics in your hard drive are, well.. does you wife know about this fetishism ?LOL!
You didn't say nothing wrong my friend. You are right on it when you think I'm a worrier, anxious and maybe a little ocd'ing (gonna need to talk about this, never though about it). So it's hard to see what's real and what's in "the head" so it's also hard to know when to remember such a person that maybe he's imaginating things.
And sometimes you just need to do cause alot of times it's the case! and if it is often the case, and you want to help.. what you can do but tell him that it could be so ? ...I'm proud to have your support and help and as we talk you only given great me great of both.
Your best crazy buddy eheh
MartyPS: When in your harddrive, I've deleted my girlfriend's pictures when I saw you did put in your the "C:\PORN\Annie\" folder.. humm humm.. ;)
> Marty,
> I hope my above post didn't upset you in any way. I know you are frustrated...i am also frustrated for you. But the last thing i want to do is hurt your feelings...i just want what's best for you bud, so you and Annie can be Happy together and of course "relax together." :) You're are my best bud in here, and i'm sorry if i said anything to upset you..okay? Things will get better soon my friend! I continue to pray for you every day.
>
> Monte ..The frustrated Crazy Horse Man :)
Posted by Caedmon on April 24, 2006, at 19:15:25
In reply to Re: Agressivity on 5mg of PARNATE, uh help? » Crazy Horse, posted by MARTY on April 24, 2006, at 14:41:16
>> -Social Phobic are believe to have some anormalities at the dopamine level; and they tend to respond badly to dopaminergic agent>>
I think the idea is that social phobia is correlated with lowered dopamine, so raising it (with bupropion, stimulants, etc) can actually be beneficial. But I am sure that there can be wide variations in individual reactions.
>> I'll talk about benzos with my Pdoc but will also as her if my reaction, my unstable and extremist (tears <-> rage) mood could be relate to my Bipolarity.. if yes, maybe it could be time to tweak a little more my "flatners" stabilizers .. >>
That gets my vote. It's possible the med change is making your moods unstable. I don't know if it would iron out over time or not, but it's worth looking at this aspect. Either stop and restart the Parnate, or try to smooth over the transition with a tweak on your mood stabilizers. Or both.
Good luck.
- C
Posted by Crazy Horse on April 24, 2006, at 19:32:44
In reply to Re: Agressivity on 5mg of PARNATE, uh help? » Crazy Horse, posted by MARTY on April 24, 2006, at 14:53:08
>
> Hey bud, relax! :P I'm not that agressive.. BTW, your windows firewall is pretty weak and your porn pics in your hard drive are, well.. does you wife know about this fetishism ?
>
> LOL!
>
> You didn't say nothing wrong my friend. You are right on it when you think I'm a worrier, anxious and maybe a little ocd'ing (gonna need to talk about this, never though about it). So it's hard to see what's real and what's in "the head" so it's also hard to know when to remember such a person that maybe he's imaginating things.
> And sometimes you just need to do cause alot of times it's the case! and if it is often the case, and you want to help.. what you can do but tell him that it could be so ? ...
>
> I'm proud to have your support and help and as we talk you only given great me great of both.
>
> Your best crazy buddy eheh
> Marty
>
> PS: When in your harddrive, I've deleted my girlfriend's pictures when I saw you did put in your the "C:\PORN\Annie\" folder.. humm humm.. ;)
>
> > Marty,
> > I hope my above post didn't upset you in any way. I know you are frustrated...i am also frustrated for you. But the last thing i want to do is hurt your feelings...i just want what's best for you bud, so you and Annie can be Happy together and of course "relax together." :) You're are my best bud in here, and i'm sorry if i said anything to upset you..okay? Things will get better soon my friend! I continue to pray for you every day.
> >
> > Monte ..The frustrated Crazy Horse Man :)
>
>You leave your hands off my Annie pictures!!! LOL
My wife reads this and i'm a dead man! :)Martin, i think you are confused about the dopamine problem. Yes, people with social phobia are deficient in Dopamine,(theoretically anyway) therefore adding dopamine will help not agitate. My doc put me on a dopamine enhancer (Mirapex) and it definitely helped my social phobia...I HATE THAT LABEL...Did you know Monte is a Social Phobic? Makes me sound like a freak! Anyway, the Mirapex was short lived but it did help for awhile. Your right about the greater chance of getting Parkinson's..because it is related to low dopamine levels.
Well...got go look at my Annie pictures.LOL Take care Louis! :)
Monte "the social misfit"
Posted by Phillipa on April 24, 2006, at 21:53:27
In reply to Re: Agressivity on 5mg of PARNATE, uh help? » Crazy Horse, posted by Crazy Horse on April 24, 2006, at 13:42:38
With a WANG!!!!! Love Phillipa
Posted by MARTY on April 24, 2006, at 23:37:06
In reply to Re: Agressivity on 5mg of PARNATE, uh help? » MARTY, posted by Crazy Horse on April 24, 2006, at 19:32:44
HiIt's scientifically not clear at this time what is the nature of the dopaminergic problem of the social phobics. A lack of dopamine is one of the theory. Others talk about to much dopamine at X place in the brain. And others are not even described in terms of too much or too less.
I'm not for or against any of those theories, but the 'lack of dopamine' cannot yet be proove with today dopamine agonists: It's well known that, for example, Wellbutrin isn't effective in SP. In fact, before Pdoc prescribe agent working mainly on dopamine, they usually wait until there is not much left to try. In SPVille, GABA and Serotonin is what composes the 90% of meds usually prescribed. The only exception I see to this logic is maybe the MAOIs which are good for SP but plays well with dopamine and NE (Parnate much more than Nardil).
That said, this explains well my problem:
My Wang likes Dopamine
My Ambitions/work likes NE
.. but My SP likes Serotonin ..damn
Marty
How do call a sioux house.. was it a "Wing Wang"?> You leave your hands off my Annie pictures!!! LOL
> My wife reads this and i'm a dead man! :)
>
> Martin, i think you are confused about the dopamine problem. Yes, people with social phobia are deficient in Dopamine,(theoretically anyway) therefore adding dopamine will help not agitate. My doc put me on a dopamine enhancer (Mirapex) and it definitely helped my social phobia...I HATE THAT LABEL...Did you know Monte is a Social Phobic? Makes me sound like a freak! Anyway, the Mirapex was short lived but it did help for awhile. Your right about the greater chance of getting Parkinson's..because it is related to low dopamine levels.
>
> Well...got go look at my Annie pictures.LOL Take care Louis! :)
>
> Monte "the social misfit"
Posted by MARTY on April 25, 2006, at 3:44:29
In reply to Agressivity on 5mg of PARNATE, uh help?, posted by Marty on April 23, 2006, at 23:10:42
Just want to thanks everyone for their support and ideas. I appreciate a lot.
Marty
Posted by Dr. Bob on April 25, 2006, at 18:03:45
In reply to Re: Agressivity on 5mg of PARNATE, uh help? » Crazy Horse, posted by Phillipa on April 24, 2006, at 21:53:27
Posted by tgo on April 26, 2006, at 16:58:38
In reply to Agressivity on 5mg of PARNATE, uh help?, posted by Marty on April 23, 2006, at 23:10:42
Your symptoms sound like you could be Bipolar II. I wonder if adding risperdal or an antipsychotic would help, sometimes they do. I would definitely gets your dr's opinion on this one, as those are not normal reactions to this med.
Posted by MARTY on April 26, 2006, at 23:05:03
In reply to Re: Agressivity on 5mg of PARNATE, uh help?, posted by tgo on April 26, 2006, at 16:58:38
Hi tgo --You're right on it. I've been diagnosed Bipolar II and I am currently taking .5 mg of Risperdal.. which is not a big dose I know.
It look like I would need more "mood flatners" (stabilizater).. but I have tried a lot of them and not much do me well. I'm taking Lamictal 300mg which maybe we could up to 400mg; but it tends to loose some of it's antidepressive at this dosage I think. The best would be to increase Risperdal but even at .5mg it gives me some weird facial pain that only anticholinergic can make go (and I hate anticholinergic feelings) and there is also the fact that I go on Parnate in hope it could be good for me at the sexual level.. Risperdal hurt me a lot there.
So.. I just don't know.
Any Idea tgo ?
Marty
> Your symptoms sound like you could be Bipolar II. I wonder if adding risperdal or an antipsychotic would help, sometimes they do. I would definitely gets your dr's opinion on this one, as those are not normal reactions to this med.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.