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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by ed_uk on August 7, 2005, at 15:49:40
Hi!
I was thinking..... (rare, I know LOL)
You're on Parnate 10mg + selegiline 1mg at the moment?
........but you're still not feeling well.
Why not drop the selegiline and increase the Parnate to 20mg?
Parnate, like selegiline, inhibits MAO-B and should (theoretically) share selegiline's (alleged) neuroprotective properties.
20mg Parnate might improve your mood, it's a much more reliable antidepressant than selegiline. Hopefully, if you stopped selegiline, your insomnia wouldn't get any worse on Parnate 20mg. I think you said you were concerned that Parnate might cause sexual dysfunction .........but sexual dysfunction doesn't seem to be that common on (low doses of) Parnate anyway. In fact, lots of people have good sex even when they're on high doses of Parnate.
I think it could be worth a try. What do you think? If you didn't like it you could always return to your previous regimen.
~Ed
Posted by Nickengland on August 7, 2005, at 16:07:32
In reply to To Declan, posted by ed_uk on August 7, 2005, at 15:49:40
>I was thinking..... (rare, I know LOL)
Ed LOL...you're not alone, my thoughts never stop!
Kind regards
Nick
Posted by Declan on August 7, 2005, at 19:31:14
In reply to Re: To Declan » ed_uk, posted by Nickengland on August 7, 2005, at 16:07:32
Yes Ed, Parnate 10mg/d, deprenyl 1mg/d is my current thing.
I think the insomniac potential of an extra 10mg/d Parnate is higher than 1mg/d deprenyl, but mood would be improved if sleep was OK. Chairman MAO said he had trouble sleeping on any dose of Parnate, but he was no doubt referring to higher doses. Laurenjb was having trouble sleeping last I heard. Of course I could take Ambien or something. It's not an ideal situation, whatever you do.
What I noticed about Parnate straight away was what is probably a seratonin effect, a sort of warmth, like a day in summer, not prosocial but perhaps pro-equilibrium, more happy being alone so to speak.
All of this is affected by being older, both sex and sleep. Neither is so robust (as they should have been, sex especially) when younger.
Certainly if I was going to sacrifice sex I would do it for Nardil.
There's almost a song there: "I did what I did for phenelzine".And thanks
Declan
Posted by ed_uk on August 8, 2005, at 14:03:29
In reply to Re: To Declan, posted by Declan on August 7, 2005, at 19:31:14
Hi Declan,
>I think the insomniac potential of an extra 10mg/d Parnate is higher than 1mg/d deprenyl....
You won't know unless you try it! ;-)
~Ed
Posted by Declan on August 8, 2005, at 15:18:29
In reply to Re: To Declan » Declan, posted by ed_uk on August 8, 2005, at 14:03:29
Did this morning Ed, 20mg Parnate at 4am (no deprenyl). Now that I feel my pulse, the BP drop is quite noticeable, plus a yawny tiredness, but no big deal. Time for a cup of tea.
Declan
Posted by ed_uk on August 8, 2005, at 15:59:25
In reply to Ed and Parnate, posted by Declan on August 8, 2005, at 15:18:29
Hi Declan,
Why not try it for a couple of weeks and see how you feel? The AD effect of Parnate can take a few weeks to 'kick in'.
>20mg Parnate at 4am
Perhaps you could try taking 10mg in the morning and 10mg at noon - this is a common regimen.
>Insomnia
Is trimipramine (Surmontil) still available in Australia? I think it is. It might be helpful for your insomnia - it can be combined with Parnate.
~Ed
Posted by ed_uk on August 8, 2005, at 17:11:49
In reply to Declan has a cup of tea » Declan, posted by ed_uk on August 8, 2005, at 15:59:25
>it (Surmontil) can be combined with Parnate.
.....apparantly, although some would disagree.
Have you ever tried zolpidem (Stilnox)?
~ed
Posted by Declan on August 8, 2005, at 18:26:42
In reply to Re: Declan has a cup of tea » ed_uk, posted by ed_uk on August 8, 2005, at 17:11:49
I think I have tried Stilnox, yes I have. I get it mixed up with Ambien, which is a similar thing maybe. Slight unpleasant taste but no big deal, I took 1/2 a tablet and it deepened sleep. I see my nice dr today and will suggest it.
Declan
Posted by ed_uk on August 9, 2005, at 13:38:16
In reply to Re: Declan has a cup of tea, posted by Declan on August 8, 2005, at 18:26:42
Hi Declan,
Stilnox is the Australian brand name for zolpidem (called Ambien in the US).
>Slight unpleasant taste but no big deal...
That was probably zopiclone (Imovane). Zopiclone isn't available in the US but it virtually identical to eszopiclone (Lunesta) - which is available in the US so there's quite a few posts about it.
Kind regards
~ed
Posted by laurenjb on August 11, 2005, at 17:53:04
In reply to Re: To Declan, posted by Declan on August 7, 2005, at 19:31:14
Hey Declan: Sorry for taking so long to respond. I have literally been delirious from not getting enough sleep. I alternate 20mg Ambien and 2mg Klonopin, with some Ativan sometimes thrown in and still only sleep about 2 nights a week. The depression is better though -- ironic! Good luck with the 20mg and keep me posted. Take care, Lauren
> Yes Ed, Parnate 10mg/d, deprenyl 1mg/d is my current thing.
>
> I think the insomniac potential of an extra 10mg/d Parnate is higher than 1mg/d deprenyl, but mood would be improved if sleep was OK. Chairman MAO said he had trouble sleeping on any dose of Parnate, but he was no doubt referring to higher doses. Laurenjb was having trouble sleeping last I heard. Of course I could take Ambien or something. It's not an ideal situation, whatever you do.
>
> What I noticed about Parnate straight away was what is probably a seratonin effect, a sort of warmth, like a day in summer, not prosocial but perhaps pro-equilibrium, more happy being alone so to speak.
>
> All of this is affected by being older, both sex and sleep. Neither is so robust (as they should have been, sex especially) when younger.
>
> Certainly if I was going to sacrifice sex I would do it for Nardil.
> There's almost a song there: "I did what I did for phenelzine".
>
> And thanks
> Declan
Posted by Declan on August 11, 2005, at 19:07:32
In reply to Re: To Declan, posted by laurenjb on August 11, 2005, at 17:53:04
Well what I have been doing is this
Deprenyl....1mg
Parnate.....10mg
Seroctin....3 caps
Which is interesting, and quite unexpected, at least the effect that Seroctin brings to the mix is. A certain warmth and sociability(!). And last night I had the best sleep I've had for months certainly, maybe a year? Nobody had heard of Seroctin round at the Alternative Board, except for Lotus who posted it.When I took 20mg Parnate it was OK, and I could see more would be an experience, but it didn't somehow seem to be something I needed more of. I felt stimulated but not peaceful enough. I've got no complaint about the chemical imbalance idea, it's just what can you do that is useful?
I suppose it depends on how crippling your depression is to begin with. Some sorts of depression are so awful that a lack of sleep is no big deal maybe, except that adequate sleep is important to wellbeing.
So Lauren, you're on 40 now?
Declan
This is the end of the thread.
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