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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 23 of 23. This is the beginning of the thread.
Posted by linkadge on November 28, 2004, at 11:59:50
Wyeth is trying to release a novel ser/nor reputake inhibitor. Why?
Linkadge
Posted by ed_uk on November 28, 2004, at 12:13:25
In reply to DVS-233 wyeth whoopty whoop., posted by linkadge on November 28, 2004, at 11:59:50
As always.......to make money! Probably they will be promotimg it when Effexor starts to loose popularity due to withdrawal symptoms.
Ed.
Posted by ed_uk on November 28, 2004, at 12:20:49
In reply to Re: DVS-233 wyeth whoopty whoop., posted by ed_uk on November 28, 2004, at 12:13:25
Mmmmm, shame the pharmaceutical companies spend so much money producing drugs with no real advantages over the drugs which are already available.
Desvenlafaxine WY 45233 DVS 233
Desvenlafaxine, an O-demethylated metabolite of venlafaxine, is being developed for the treatment of depression. Desvenlafaxine inhibits serotonin and noradrenaline reuptake and **has demonstrated antidepressant effect very similar to venlafaxine** in pre-clinical studies. Phase III trials for the treatment of major depressive disorder are underway in the USA.
Oh yay, what an innovation!!!!
Posted by linkadge on November 28, 2004, at 12:27:39
In reply to Re: DVS-233 wyeth whoopty whoop., posted by ed_uk on November 28, 2004, at 12:20:49
it guess DVS-233 is to effexor what lexapro is to celexa.
Linkadge
Posted by ed_uk on November 28, 2004, at 12:29:20
In reply to Re: DVS-233 wyeth whoopty whoop., posted by ed_uk on November 28, 2004, at 12:20:49
..... I guess they don't want Cymbalta to overtake Effexor in popularity. I'm sure Wyeth will come up with some half-baked reason why their new drug is superior!
Posted by ed_uk on November 28, 2004, at 12:51:51
In reply to Re: The joy of Effexor, posted by ed_uk on November 28, 2004, at 12:29:20
He He.... I'm convinced that escitalopram was one of the most over-hyped drugs of recent years. Hardly a breakthrough in psychopharmacology! It was a cynical exploitation of patent law!
I wonder what the trade name for desvenlafaxine will be...
ProEffexor?
Novo-Effexor?
SuperEffexor
Effexapro?
Posted by jlbl2l on November 28, 2004, at 13:46:01
In reply to Re: The joy of Effexor, posted by ed_uk on November 28, 2004, at 12:51:51
Posted by linkadge on November 28, 2004, at 14:08:07
In reply to Re: The joy of Effexor, posted by ed_uk on November 28, 2004, at 12:51:51
It's getting to the point where I could probably synthesize my own ser/nor reputake inhibitor.
(kidding)You can practically buy them by the scoopfull in the bulk store.
I really hope that the drug companies periodically visit these sites just to see how ashamed I am of them.
Linkadge
Posted by jlbl2l on November 28, 2004, at 14:18:47
In reply to Re: The joy of Effexor, posted by linkadge on November 28, 2004, at 14:08:07
see now its different when its comes to a medicine that you find useful, such as Lyrica (which in all fairness isn't an isomer os neurontin, but is very related) and Lyrica is an improvement upon Neurontin and perhaps Nuvigil may be an improvment upon Provigil.
Posted by ed_uk on November 28, 2004, at 14:22:11
In reply to Re: The joy of Effexor, posted by linkadge on November 28, 2004, at 14:08:07
Hi Linkadge,
If anyone invents a 'new' SSRI I will scream! We don't need more SSRIs, we need something completely new. A dop/ser reuptake inhibitor might be a good place to start, or maybe a dop/nor/ser reuptake inhibitor.
You seem happier today btw, it's good.
Ed.
Posted by linkadge on November 28, 2004, at 14:28:15
In reply to Re: The joy of Effexor, posted by ed_uk on November 28, 2004, at 14:22:11
Yeah, I had a night of sleep deprivation.
It aways works, but as soon as I fall asleep the body snachers will take over.Linkadge
Posted by linkadge on November 28, 2004, at 14:29:38
In reply to Re: The joy of Effexor, posted by ed_uk on November 28, 2004, at 14:22:11
I thought they should combine a cortisol regulating drug, with a drug that boosts BDNF.
Ie Mifestiprone + BDNF injections.
Linkadge
Posted by ed_uk on November 28, 2004, at 14:30:54
In reply to Re: The joy of Effexor, posted by jlbl2l on November 28, 2004, at 14:18:47
Hi,
A least pregabalin is a new molecule! Anyway, it remains to be seen how many people will find it better than gabapentin. It's so new. Some people might even prefer gabapentin! Also, some people might find it better than gabapentin because of a stronger placebo effect. Whenever people are led to believe that a new drug will be more effective, they often find that it is more effective. Results of medication are dependent on expectations as well as pharmacology!
Regards,
Ed.PS. Glad you like Lyrica. Look forward to hearing updates.
Posted by jlbl2l on November 28, 2004, at 14:35:34
In reply to Re: To jlb121, posted by ed_uk on November 28, 2004, at 14:30:54
TRUST me, even if people dont find Lyrica that helpful or mildly helpful for there condition, it is FAR superior than Neurontin! LOL! Mark my words - i know that no one would go back to Neurontin after using Lyrica (keep in mind using dose equivalents)
JLB
Posted by ed_uk on November 28, 2004, at 15:06:46
In reply to Re: To jlb121, posted by jlbl2l on November 28, 2004, at 14:35:34
Hi,
Do you want to try mifepristone?
Ed.
Posted by linkadge on November 28, 2004, at 15:13:36
In reply to Re: To Link, posted by ed_uk on November 28, 2004, at 15:06:46
I would give my eye teeth to try something novel.
Linkadge
Posted by ed_uk on November 28, 2004, at 15:29:09
In reply to Re: To Link, posted by linkadge on November 28, 2004, at 15:13:36
You'll have to gently encourage your pdoc to give you Nardil or Lamictal. You could suggest adding Nardil and Zyprexa to your Lithium. Have you stopped the Celexa now? Maybe you'd do well on Nardil+Lamictal+Lithium+Zyprexa !!! Big combination!
Ed.
Posted by linkadge on November 28, 2004, at 16:33:32
In reply to Re: To Link, posted by ed_uk on November 28, 2004, at 15:29:09
I would probably start with fewer meds. I've been on the giant list of combo's and I oftentimes find they just don't mix.
Linkadge
Posted by ed_uk on November 28, 2004, at 16:38:48
In reply to Re: To Link, posted by linkadge on November 28, 2004, at 16:33:32
I wasn't suggesting that you should start them all at once!! Perhaps you could start Nardil and then add an antipsychotic if necessary.
Ed.
Posted by linkadge on November 28, 2004, at 16:49:05
In reply to Re: To Linkadge, posted by ed_uk on November 28, 2004, at 16:38:48
Posted by snapper on November 28, 2004, at 22:56:28
In reply to Re: The joy of Effexor, posted by ed_uk on November 28, 2004, at 12:51:51
> He He.... I'm convinced that escitalopram was one of the most over-hyped drugs of recent years. Hardly a breakthrough in psychopharmacology! It was a cynical exploitation of patent law!
>
> I wonder what the trade name for desvenlafaxine will be...
>
> ProEffexor?
>
> Novo-Effexor?
>
> SuperEffexor
>
> Effexapro?
>
> ha! lol!
how about "Nex-Effexor"
>
>
Posted by gromit on November 28, 2004, at 23:37:58
In reply to Re: The joy of Effexor, posted by ed_uk on November 28, 2004, at 12:51:51
> He He.... I'm convinced that escitalopram was one of the most over-hyped drugs of recent years. Hardly a breakthrough in psychopharmacology! It was a cynical exploitation of patent law!
When does Provigil go off patent, when is Nuvigil expected to be released? I really don't know. It seems to me that there have been several drugs that were about to go off patent and suddenly an extended release version shows up.
Rick
Posted by maxnort on December 15, 2006, at 8:36:04
In reply to Re: DVS-233 wyeth whoopty whoop., posted by ed_uk on November 28, 2004, at 12:20:49
> Mmmmm, shame the pharmaceutical companies spend so much money producing drugs with no real advantages over the drugs which are already available.
>
> Desvenlafaxine WY 45233 DVS 233
>
> Desvenlafaxine, an O-demethylated metabolite of venlafaxine, is being developed for the treatment of depression. Desvenlafaxine inhibits serotonin and noradrenaline reuptake and **has demonstrated antidepressant effect very similar to venlafaxine** in pre-clinical studies. Phase III trials for the treatment of major depressive disorder are underway in the USA.
>
> Oh yay, what an innovation!!!!
>I don't know if it's all that bad; my wife did the trials for it fine, and can't take venlafaxine
This is the end of the thread.
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