![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by geno on November 18, 2001, at 21:22:16
Hi, i have a question about this. I currently take remeron 30mg. Besides it sleep enhancing properties, due to histamine blockade, i get a nice antianxiety effect, not as powerful as benzos but average.
Does 5ht2 blockade, also effect dopamine excess. I find when im using remeron, and take a stimulant, wheater its ephedra, caffiene, i dont feel as panicy, stimulated, as opposed to taken without remeron.
I feel i suffer from excess dopamine due to ghb usage. Remeron levels me out. Without remeron, i feel very anxious, dread, doom, helpless, dipersonilization, parinoia etc.geno
Posted by JohnX2 on November 18, 2001, at 22:30:39
In reply to 5ht-2 antagonism, posted by geno on November 18, 2001, at 21:22:16
Yes, there is an inverse relationship between
the 5ht-2 receptors and dopamine stimulation in
many area of the noggin.
i.e. blocking 5ht-2 = more dopamine.
But generally blocking the 5ht-2 receptor
leads to less anxiety.Remeron also blocks a Noradrenaline feedback
receptor called alpha-2. This can cause extra
noradrenaline transmission in a part of the
brain responsible for the fight/flight response.
This could actually create a bit of anxiety, but
it helps with depression as it indirectly
stimulates dopamine transmission.Both are working together as a team.
That is primarily what makes Remeron tick.regards,
john
> Hi, i have a question about this. I currently take remeron 30mg. Besides it sleep enhancing properties, due to histamine blockade, i get a nice antianxiety effect, not as powerful as benzos but average.
> Does 5ht2 blockade, also effect dopamine excess. I find when im using remeron, and take a stimulant, wheater its ephedra, caffiene, i dont feel as panicy, stimulated, as opposed to taken without remeron.
> I feel i suffer from excess dopamine due to ghb usage. Remeron levels me out. Without remeron, i feel very anxious, dread, doom, helpless, dipersonilization, parinoia etc.
>
> geno
Posted by JGalt on November 19, 2001, at 16:09:36
In reply to Re: 5ht-2 antagonism » geno, posted by JohnX2 on November 18, 2001, at 22:30:39
Just wanted to add, remeron's actions are very similar to yohimbine, with the exception of the antihistamine effect, which yohimbine does not have. Yohimbine is not an antianxiety, in fact raises anxiety in some people, thus I tend to think that remeron is kinda like taking yohimbine and benadryl at the same time. If you've ever taken benadryl with any stimulant, you know that the stimulant's effects are greatly reduced. Ephedrine works primarily by raising norepinephrine levels (caffeine does this too indirectly), remeron's actions involving a2 antagonism may cause more serotonin to be released when you take ephedrine, thus it won't give you as much anxiety if it normally gives you that.
Also, ghb raises dopamine levels in the brain temporarily by slowing the release of dopamine and regulating the frequency of dopamine release. Once you come off, the brain returns to normal in fairly short order after the ghb clears out (8 hrs after a dose you're completely back to normal). So if you have high dopamine levels, its not from ghb (unless you're taking it right now).
Best Regards,
JGalt
Posted by geno on November 19, 2001, at 18:33:26
In reply to Re: 5ht-2 antagonism, posted by JGalt on November 19, 2001, at 16:09:36
> Just wanted to add, remeron's actions are very similar to yohimbine, with the exception of the antihistamine effect, which yohimbine does not have. Yohimbine is not an antianxiety, in fact raises anxiety in some people, thus I tend to think that remeron is kinda like taking yohimbine and benadryl at the same time. If you've ever taken benadryl with any stimulant, you know that the stimulant's effects are greatly reduced. Ephedrine works primarily by raising norepinephrine levels (caffeine does this too indirectly), remeron's actions involving a2 antagonism may cause more serotonin to be released when you take ephedrine, thus it won't give you as much anxiety if it normally gives you that.
>
> Also, ghb raises dopamine levels in the brain temporarily by slowing the release of dopamine and regulating the frequency of dopamine release. Once you come off, the brain returns to normal in fairly short order after the ghb clears out (8 hrs after a dose you're completely back to normal). So if you have high dopamine levels, its not from ghb (unless you're taking it right now).
>
> Best Regards,
> JGalti agree with you, reguarding ghb, and dopamine, but when ghb wears off, i feel the dopamine being released, ie : anxiety,, nervousness, dread, panicy, requiring me to redose.
Posted by jazzdog on November 19, 2001, at 19:21:37
In reply to Re: 5ht-2 antagonism, posted by geno on November 19, 2001, at 18:33:26
> i agree with you, reguarding ghb, and dopamine, but when ghb wears off, i feel the dopamine being released, ie : anxiety,, nervousness, dread, panicy, requiring me to redose.I think that's called addiction.
- Jane
Posted by JGalt on November 20, 2001, at 11:49:48
In reply to Re: 5ht-2 antagonism » geno, posted by jazzdog on November 19, 2001, at 19:21:37
Have you looked into 1,4 butanediol or are you able to obtain it? Its what I've used and tends to have a much more gradual, pleasant dopamine release than ghb. Other than that it works basically the same, it goes to the liver, gets metabolised to ghb (slower onset to action but also lasts significantly longer), goes to your brain, same effect.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.