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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by J on July 1, 2001, at 18:48:18
Hi all. I'm curious about what exactly tianeptine's mechanism of action is supposed to be. Tianeptine is classified as a serotonin reuptake enhancer, but somehow I get the feeling that its antidepressant effects have little to do with decreased serotonin. The reason for my hypothesis is that the short-term effects of tianeptine on me almost exactly duplicated what I felt on amineptine - a potent dopamine uptake inhibitor. It's also too much of a coincidence that tianeptine is chemically related to amineptiene. On the other hand, the following study concludes that tianeptine is definitely _not_ a dopamine uptake inhibitor:
http://www.smart-drugs.net/tianeptine/tianeptine-8.htmSo how does tianeptine work anyway? The best AD response I have ever had occurs about 1/2 hour after I take 75mg of tianeptine, but this response only lasts for about an hour. Tianeptine gives me a lot of hope, because it provides a brief glimpse of what life could be like. I'm convinced that my response to tianeptine is a major clue in figuring out what neurotransmitters I should be targeting. So I would really like to know how tianeptine is supposed to work, and what other drugs have similar mechanisms. Thanks a lot.
Keep fighting,
J.
Posted by SalArmy4me on July 1, 2001, at 19:04:04
In reply to Q. about tianeptine for the pharm. experts, posted by J on July 1, 2001, at 18:48:18
Mennini T, Mocaer E, Garattini S, Tianeptine A. Selective enhancer of serotonin uptake in rat brain. Naunyn Schmiedebergs Arch Pharmacol 1987;336:478-82:
Tianeptine is a tricyclic agent provided with antidepressant activity in experimental models and in clinical trials. In vitro tianeptine and its two principal metabolites have no effects on monoamine uptake, release or neurotransmitter receptor binding. The biochemical effect of tianeptine in vivo after acute or repeated treatment indicates an enhanced serotonin uptake in cortex and hippocampus but not in mesencephalon, with no effect on noradrenaline or dopamine uptake. This enhanced serotonin uptake is not due to decrease in serotonin release, but is related to increase in the Vmax of the uptake carrier for serotonin.
Posted by J on July 1, 2001, at 19:17:46
In reply to Re: Q. about tianeptine for the pharm. experts, posted by SalArmy4me on July 1, 2001, at 19:04:04
> Mennini T, Mocaer E, Garattini S, Tianeptine A. Selective enhancer of serotonin uptake in rat brain. Naunyn Schmiedebergs Arch Pharmacol 1987;336:478-82:
>
> Tianeptine is a tricyclic agent provided with antidepressant activity in experimental models and in clinical trials. In vitro tianeptine and its two principal metabolites have no effects on monoamine uptake, release or neurotransmitter receptor binding. The biochemical effect of tianeptine in vivo after acute or repeated treatment indicates an enhanced serotonin uptake in cortex and hippocampus but not in mesencephalon, with no effect on noradrenaline or dopamine uptake. This enhanced serotonin uptake is not due to decrease in serotonin release, but is related to increase in the Vmax of the uptake carrier for serotonin.Hmm. So tianeptine has no effect on monoamine availability. So how the blazes does it work? Tinapetine give me an unbelievable AD response about after 1/2 hour after ingesting 75mg. I got exactly the response when I took amineptine - which _is_ a dopamine uptake inhibitor.
This is very puzzling.
Posted by Fred Potter on July 1, 2001, at 20:29:13
In reply to Re: Q. about tianeptine for the pharm. experts, posted by J on July 1, 2001, at 19:17:46
A recent article in New Scientist discusses the possible role of an over-active immune system in depression. It also suggests that some anti-inflammatory drugs might act as anti-depressants in some cases. I believe Tianeptine also has anti-inflammatory properties. But before we all run to the pharmacist for some Ibuprofen, they go on to say that won't work.
Makes me think the whole serotonin model may be horribly wrong
Posted by Zo on July 1, 2001, at 23:14:12
In reply to Re: Q. about tianeptine for the pharm. experts, posted by Fred Potter on July 1, 2001, at 20:29:13
> Makes me think the whole serotonin model may be horribly wrongI always thought the whole serotonin model is horribly wrong. And SSRIs did punk-all for me. Dopamine is *so* much more key. . . to reward, to pleasure, to clarity, to all the things that feel good.
Don't get me started! :)
Zo
Posted by Pacha on July 2, 2001, at 1:58:30
In reply to Q. about tianeptine for the pharm. experts, posted by J on July 1, 2001, at 18:48:18
Tianeptine cured my asthma. Last year i needed to use three different inhalers three times a day.
I tried Tian for depression, it helped to a certain extent. After a few weeks i noticed that i had very little to no asthma, so i continued it for 7 months. Decided to stop, and 3 months later still no asthma (and its the middle of hayfever season). Unbelievable.
I was a little trigger happy with my cc and have over 300 tabs left, if anyone wants them ?
This is the end of the thread.
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