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Q. about tianeptine for the pharm. experts

Posted by J on July 1, 2001, at 18:48:18

Hi all. I'm curious about what exactly tianeptine's mechanism of action is supposed to be. Tianeptine is classified as a serotonin reuptake enhancer, but somehow I get the feeling that its antidepressant effects have little to do with decreased serotonin. The reason for my hypothesis is that the short-term effects of tianeptine on me almost exactly duplicated what I felt on amineptine - a potent dopamine uptake inhibitor. It's also too much of a coincidence that tianeptine is chemically related to amineptiene. On the other hand, the following study concludes that tianeptine is definitely _not_ a dopamine uptake inhibitor:
http://www.smart-drugs.net/tianeptine/tianeptine-8.htm

So how does tianeptine work anyway? The best AD response I have ever had occurs about 1/2 hour after I take 75mg of tianeptine, but this response only lasts for about an hour. Tianeptine gives me a lot of hope, because it provides a brief glimpse of what life could be like. I'm convinced that my response to tianeptine is a major clue in figuring out what neurotransmitters I should be targeting. So I would really like to know how tianeptine is supposed to work, and what other drugs have similar mechanisms. Thanks a lot.

Keep fighting,
J.


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poster:J thread:68639
URL: http://www.dr-bob.org/babble/20010701/msgs/68639.html