Posted by J on July 1, 2001, at 19:17:46
In reply to Re: Q. about tianeptine for the pharm. experts, posted by SalArmy4me on July 1, 2001, at 19:04:04
> Mennini T, Mocaer E, Garattini S, Tianeptine A. Selective enhancer of serotonin uptake in rat brain. Naunyn Schmiedebergs Arch Pharmacol 1987;336:478-82:
>
> Tianeptine is a tricyclic agent provided with antidepressant activity in experimental models and in clinical trials. In vitro tianeptine and its two principal metabolites have no effects on monoamine uptake, release or neurotransmitter receptor binding. The biochemical effect of tianeptine in vivo after acute or repeated treatment indicates an enhanced serotonin uptake in cortex and hippocampus but not in mesencephalon, with no effect on noradrenaline or dopamine uptake. This enhanced serotonin uptake is not due to decrease in serotonin release, but is related to increase in the Vmax of the uptake carrier for serotonin.Hmm. So tianeptine has no effect on monoamine availability. So how the blazes does it work? Tinapetine give me an unbelievable AD response about after 1/2 hour after ingesting 75mg. I got exactly the response when I took amineptine - which _is_ a dopamine uptake inhibitor.
This is very puzzling.
poster:J
thread:68639
URL: http://www.dr-bob.org/babble/20010701/msgs/68645.html