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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by PhoenixGirl on January 31, 2001, at 15:13:27
In reply to Serotonin antagonists, Where to get RITANSERIN??, posted by PhoenixGirl on January 30, 2001, at 16:22:05
> Who knows what serotonin antagonists there are? I know that ritanserin, cyproheptadine, remeron, serzone, and mainserin are serotonin antagonists. I'd really like to know of the serotonin antagonists that do not antagonize dopamine and do not increase other kinds of serotonin.
> Also, is ritanserin being produced anywhere, and where can it be bought? Thanks!
Posted by anita on February 2, 2001, at 8:34:37
In reply to Serotonin antagonists, Where to get RITANSERIN??, posted by PhoenixGirl on January 31, 2001, at 15:13:27
Ritanserin isn't available anywhere as far as I know (I've looked), but ketanserin, very much the same, is available from an overseas pharmacy in India. If you're really interested, I'll find the web site. I think, tho, that the manufacturer has stopped making it, so you might not be able to use it long-term. I do know that both ritanserin and ketanserin were in clinical trials and they proved ineffective for schizophrenia, but I think they're in trials for depression now.
If you take a low enough dose of risperidone or zyprexa, you should be able to antagonize the 5HT2 receptors without antagonizing dopamine receptors or affecting other serotonin receptors, and maybe even increase dopamine. So, I'd try those first. Personally, I've benefited from low-dose risperidone for depression.
Cyproheptadine has yucky side effects and I believe it can cause weight gain.
anita
> > Who knows what serotonin antagonists there are? I know that ritanserin, cyproheptadine, remeron, serzone, and mainserin are serotonin antagonists. I'd really like to know of the serotonin antagonists that do not antagonize dopamine and do not increase other kinds of serotonin.
> > Also, is ritanserin being produced anywhere, and where can it be bought? Thanks!
Posted by PhoenixGirl on February 2, 2001, at 12:59:13
In reply to Re: Serotonin antagonists, Where to get RITANSERIN??, posted by anita on February 2, 2001, at 8:34:37
Hey Anita,
I'd like to know the web address for the Indian place selling ketanserin. I read from a recent book on ADs that ritanserin is not being studied for depression anymore, but for "other psychiatric illnesses". Didn't say which ones, and I don't know if it was dropped for depression because it was not very effective, or some economic/political bullshit in the pharmaceutical industry.
I have some cyproheptadine, and it does nothing for the sexual dysfunction. It only makes my eyes dry. I don't know what the hell to do.Ritanserin isn't available anywhere as far as I know (I've looked), but ketanserin, very much the same, is available from an overseas pharmacy in India. If you're really interested, I'll find the web site. I think, tho, that the manufacturer has stopped making it, so you might not be able to use it long-term. I do know that both ritanserin and ketanserin were in clinical trials and they proved ineffective for schizophrenia, but I think they're in trials for depression now.
>
> If you take a low enough dose of risperidone or zyprexa, you should be able to antagonize the 5HT2 receptors without antagonizing dopamine receptors or affecting other serotonin receptors, and maybe even increase dopamine. So, I'd try those first. Personally, I've benefited from low-dose risperidone for depression.
>
> Cyproheptadine has yucky side effects and I believe it can cause weight gain.
>
> anita
>
>
> > > Who knows what serotonin antagonists there are? I know that ritanserin, cyproheptadine, remeron, serzone, and mainserin are serotonin antagonists. I'd really like to know of the serotonin antagonists that do not antagonize dopamine and do not increase other kinds of serotonin.
> > > Also, is ritanserin being produced anywhere, and where can it be bought? Thanks!
Posted by Jonathan on February 12, 2001, at 1:21:15
In reply to Re: Serotonin antagonists, Where to get RITANSERIN??, posted by anita on February 2, 2001, at 8:34:37
Anita,
Ketanserin (Italian generic name ketanserina) is available from Farmacia Cerati, brand name Sufrexal (manuf. Janssen Cilag SpA). 30 tablets, each containing 40 mg of the tartrate, cost Euro 23.26 (about $20) plus shipping. Its most common clinical use is for hypertension.
Do you have any information about the dosage that is being used in clinical trials as an antidepressant? I ran a quick Medline search, couldn't find anything, but could easily have somehow missed the crucial paper.
TIA,
Jonathan.
> Ritanserin isn't available anywhere as far as I know (I've looked), but ketanserin, very much the same, is available from an overseas pharmacy in India. If you're really interested, I'll find the web site. I think, tho, that the manufacturer has stopped making it, so you might not be able to use it long-term. I do know that both ritanserin and ketanserin were in clinical trials and they proved ineffective for schizophrenia, but I think they're in trials for depression now.
>
> anita
Posted by Jonathan on February 12, 2001, at 12:58:43
In reply to Re: Serotonin antagonists, Where to get RITANSERIN??, posted by anita on February 2, 2001, at 8:34:37
Anita,
Ketanserin (Italian generic name ketanserina) is available from Farmacia Cerati, brand name Sufrexal (manuf. Janssen Cilag SpA). 30 tablets, each containing 40 mg of the tartrate, cost Euro 23.26 (about $20) plus shipping. Its most common clinical use is for hypertension.
Do you have any information about the dosage that is being used in clinical trials as an antidepressant? I ran a quick Medline search, couldn't find anything, but could easily have somehow missed the crucial paper.
TIA,
Jonathan.
> Ritanserin isn't available anywhere as far as I know (I've looked), but ketanserin, very much the same, is available from an overseas pharmacy in India. If you're really interested, I'll find the web site. I think, tho, that the manufacturer has stopped making it, so you might not be able to use it long-term. I do know that both ritanserin and ketanserin were in clinical trials and they proved ineffective for schizophrenia, but I think they're in trials for depression now.
>
> anita
Posted by Malin on April 5, 2002, at 6:27:25
In reply to Ketanserin » anita, posted by Jonathan on February 12, 2001, at 12:58:43
Jonathan,
Do you know if Farmacia Cerati also have ketanserine available as solution for injection?
I've tried to explore their home-page but could not find anything about ketanserine there.
Malin
> Anita,
>
> Ketanserin (Italian generic name ketanserina) is available from Farmacia Cerati, brand name Sufrexal (manuf. Janssen Cilag SpA). 30 tablets, each containing 40 mg of the tartrate, cost Euro 23.26 (about $20) plus shipping. Its most common clinical use is for hypertension.
>
> Do you have any information about the dosage that is being used in clinical trials as an antidepressant? I ran a quick Medline search, couldn't find anything, but could easily have somehow missed the crucial paper.
>
> TIA,
>
> Jonathan.
>
> > Ritanserin isn't available anywhere as far as I know (I've looked), but ketanserin, very much the same, is available from an overseas pharmacy in India. If you're really interested, I'll find the web site. I think, tho, that the manufacturer has stopped making it, so you might not be able to use it long-term. I do know that both ritanserin and ketanserin were in clinical trials and they proved ineffective for schizophrenia, but I think they're in trials for depression now.
> >
> > anita
Posted by Jonathan on April 5, 2002, at 11:48:33
In reply to Re: Ketanserin, posted by Malin on April 5, 2002, at 6:27:25
Welcome, Malin :)
I'm afraid that this site's policy on posting info about specific pharmacies has changed since I posted the message you have just answered, more than a year ago. Although we Europeans are unaffected by US import regulations, we're still not allowed to exchange info about how to get non-FDA approved drugs; this apparently even includes exchanging email addresses for that purpose: I'm sorry.
http://www.dr-bob.org/babble/faq.html#illegal
It's fine to talk about their pharmacology, though, so I CAN say that I never found the dosage information I was seeking. I was interested in ketanserin because I wanted something with nefazodone's affinity for 5HT-2 receptors, but which didn't antagonise alpha-1 noradrenoceptors. I subsequently found out that ketanserin IS a strong alpha-1 antagonist after all :(
There are a couple of regular posters here from your country, who may be able to tell you how to obtain either ketanserin or a suitable equivalent through the Swedish health service.
[Parental discretion is advised - the next couple of paragraphs are strictly for adults only]
I doubt if I'm even allowed to say that your name reminds me of a superb pub at Malin Head, Co Donegal, Ireland, which (legally) serves the best pint of Guinness I've tasted anywhere to anyone over 18, in case American kids aged 18-21 read this.
Besides, I'm trying to keep a low profile because one of my posts, which included the non-Cockney version of the forbidden word "bib", just slipped into the archives in the nick of time before Trouble was banned for using the same word!
[Parental controls off]
Seriously, this is a US-based site and it would be bad for all of us if Dr Bob fell foul of the law because of something posted here, and perhaps lost charitable tax exemption for donations which pay only part of the cost of running Psycho-Babble (Dr Bob pays the rest himself): "the good of the many outweighs the good of the few"
http://www.dr-bob.org/babble/admin/20020308/msgs/3793.html
If you come back in the 23rd Century, Americans will have adopted the Prime Directive, which will forbid them from imposing their own laws and customs on us aliens ;)
Live long and prosper \\//
Jonathan.
Posted by Anna P. on April 6, 2002, at 13:59:16
In reply to Re: Ketanserin » Malin, anyone in Sweden, posted by Jonathan on April 5, 2002, at 11:48:33
Does anyone has any information if Ketanserin works for depression?
This is the end of the thread.
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