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Dr. Bob is Robert Hsiung, MD,
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Posted by chuck on May 18, 1999, at 12:16:00
In reply to opioid agonist/antagonist discussion mailing list, posted by Elizabeth on April 20, 1999, at 17:28:53
>I would love to get on this mailing list---->started taking naltrexone about 4 weeks ago (with Zoloft, for last four years) with some results, though I'm not altogether sure what they are; that is, if if has 'boosted' my SSRI, it has done so only slightly. thanks.
Posted by Elizabeth on May 18, 1999, at 17:52:35
In reply to Re: Not doing so good., posted by PattyG on May 18, 1999, at 11:27:27
Yeah, Revia is a brand name of naltrexone. (Another one I've heard is Trexan.)
The active ingredients in kudzu root are alcohol dehydrogenase inhibitors, I think...it doesn't work the same way as naltrexone does, anyway.
Posted by PattyG on May 18, 1999, at 23:35:41
In reply to naltrexone - Patty, posted by Elizabeth on May 18, 1999, at 17:52:35
(Elizabeth wrote)Yeah, Revia is a brand name of naltrexone. (Another one I've heard is Trexan.)
The active ingredients in kudzu root are alcohol dehydrogenase inhibitors, I think...it doesn't work the same way
as naltrexone does, anyway.////Sorry for being so....dumb....but are you saying that Naltrexone is, then, the generic of Revia? And what is Trexan? Haven't heard of that one. Also, I attended a workshop at the State Mental Health Convention on the Neurobiology of Addiction and the psychiatrist mentioned Kudzuroot and I was under the impression that he was inferring this worked in the same manner as Naltrexone. In what way do you know it to be effective? Thanks for any info you have!
Posted by Wayne R. on May 19, 1999, at 5:42:34
In reply to Re: naltrexone - Patty, posted by PattyG on May 18, 1999, at 23:35:41
Patty,
Naltrexone is the generic name. It has only been available as a generic for a year or so. Revia and Trexan are manufacturers brand names of the same thing.
Naltrexone has FDA approval for the treatment of certain drug and alcohol addictions. It fills in or blocks the receptors that influence the action of and craving for those drugs, etc. Naltrexone was accidentally discovered to help some people with hard to treat depression when combined with an SSRI type antidepressant. Nobody seems to know why this even works as yet. You may wish to review my postings since February to get more information. Best regards… Wayne
Posted by PattyG on May 19, 1999, at 7:33:20
In reply to Re: naltrexone - Patty, posted by Wayne R. on May 19, 1999, at 5:42:34
Okay, now what I need to know is if it could be possible that the folks who are having difficulty taking Naltrexone (headaches, nausea, etc.) would fair better with Revia (the non-generic drug?) Anyone have any info on this? THanks much!
Posted by Wayne R. on May 19, 1999, at 11:56:50
In reply to Re: naltrexone - Wayne, posted by PattyG on May 19, 1999, at 7:33:20
The generics are supposed to be made to the same standards and so it should not make any difference. I started on Revia and switched to the generic Naltrexone and I have noticed no difference in relief, side effects (none for me), etc. Wayne
Posted by Elizabeth on May 20, 1999, at 2:19:10
In reply to Re: naltrexone - Patty, posted by Wayne R. on May 19, 1999, at 11:56:50
Hi Patty. You're not dumb - I'm sorry if it sounded like I was talking down to you!
As to the mechanism of kudzu root, I looked into it some more and it doesn't seem like it's quite that simple. But I *don't* know of any evidence that it works in the way that naltrexone is known to work.
There are a couple of studies that have been done or are being done in rodents. I remember some stuff a few years ago by Keung and colleagues. I don't know if they're still working on it.
Posted by Dr Haraldur Erlendsson on February 1, 2000, at 8:02:22
In reply to Re: Refractory depression--naltrexone theories?, posted by Jim on April 14, 1999, at 7:37:18
Are you aware of the animal studies
of learned helplessness and
naltrexone
Posted by PattyG on February 1, 2000, at 21:04:19
In reply to Re: Refractory depression--naltrexone theories?, posted by Dr Haraldur Erlendsson on February 1, 2000, at 8:02:22
> Are you aware of the animal studies
> of learned helplessness and
> naltrexone////No. Please advise!
Posted by Anna P. on February 3, 2000, at 16:54:50
In reply to Re: Refractory depression--naltrexone theories?, posted by PattyG on February 1, 2000, at 21:04:19
> > Are you aware of the animal studies
> > of learned helplessness and
> > naltrexone
>
> ////No. Please advise!Naltrexone has helped me to avoid Lithium( I'm already seriously overweight) by preventing the fading of the antidepressant.
Anna P.
Posted by Scott L. Schofield on February 6, 2000, at 9:28:58
In reply to Re: Refractory depression--naltrexone theories?, posted by Anna P. on February 3, 2000, at 16:54:50
> Naltrexone has helped me to avoid Lithium( I'm already seriously overweight) by preventing the fading of the antidepressant.
Which one?
Thanks.
- Scott
Posted by Janet from Brazil on February 6, 2000, at 15:56:43
In reply to Re: Refractory depression--naltrexone theories?, posted by Dr Haraldur Erlendsson on February 1, 2000, at 8:02:22
> Are you aware of the animal studies
> of learned helplessness and
> naltrexoneCould you please give me a synopsis of these studies as I'M interested.Thank you
Posted by Anna P. on February 8, 2000, at 21:48:37
In reply to Re: Refractory depression--naltrexone theories?, posted by Scott L. Schofield on February 6, 2000, at 9:28:58
> > Naltrexone has helped me to avoid Lithium( I'm already seriously overweight) by preventing the fading of the antidepressant.
>
> Which one?
>
> I've found out the only combo working for me is Moclobemide - Naltrexone, but I read that Naltrexone helps with SSIR's poop out.
Whereas all medication stop working in my case, a single doze of the Naltrexone stays in my body for up to 8 hours,
augmenting Moclobemide.Anna P.
Posted by Fred Potter on January 23, 2001, at 16:24:50
In reply to opioid agonist/antagonist discussion mailing list, posted by Elizabeth on April 20, 1999, at 17:28:53
25 mg of Naltrexone augmenting 40mg Prozac has given me the fullest antidepressant anti-anxiety response I've had in all my 37 years of suffering. It's very expensive though, and some family friction is being caused by this. If it's not too late to be put on the mailing list I would be most grateful. I'm a fan
Fred
Posted by J.Lester on January 25, 2001, at 19:45:57
In reply to Re: opioid agonist/antagonist discussion mailing list, posted by Fred Potter on January 23, 2001, at 16:24:50
> 25 mg of Naltrexone augmenting 40mg Prozac has given me the fullest antidepressant anti-anxiety response I've had in all my 37 years of suffering. It's very expensive though, and some family friction is being caused by this. If it's not too late to be put on the mailing list I would be most grateful. I'm a fan
> FredIs it true that it's only effective with SSRIs ? I hate them. How about the rest of ADs ?
Posted by SLS on January 25, 2001, at 21:34:31
In reply to Naltrexone only with SSRIs ?, posted by J.Lester on January 25, 2001, at 19:45:57
> > 25 mg of Naltrexone augmenting 40mg Prozac has given me the fullest antidepressant anti-anxiety response I've had in all my 37 years of suffering. It's very expensive though, and some family friction is being caused by this. If it's not too late to be put on the mailing list I would be most grateful. I'm a fan
> > Fred
>
> Is it true that it's only effective with SSRIs ? I hate them. How about the rest of ADs ?
It seems to work with Nardil.
- Scott
Posted by ChrisK on January 26, 2001, at 5:26:47
In reply to Naltrexone only with SSRIs ?, posted by J.Lester on January 25, 2001, at 19:45:57
I've taken it succesfully with Nortriptyline.
> > 25 mg of Naltrexone augmenting 40mg Prozac has given me the fullest antidepressant anti-anxiety response I've had in all my 37 years of suffering. It's very expensive though, and some family friction is being caused by this. If it's not too late to be put on the mailing list I would be most grateful. I'm a fan
> > Fred
>
> Is it true that it's only effective with SSRIs ? I hate them. How about the rest of ADs ?
Posted by sweetmarie on April 5, 2001, at 7:58:07
In reply to Re: Dysthymia/Treatment Resistant Depressions, posted by Nick on April 10, 1999, at 13:27:22
> > In November of last year a miracle happened which was the augmentation of Prozac with Naltrexone..... However, nobody has been able to give me a hint as to why this combination should work. Can anyone speculate about this? Wayne
>
> OK big guess coming up! There is cross - talk between Opiate systems and Noradrenergic systems - it MAY be (wild guess) that naltrexone operating through the opiate system somehow activates noradrenergic transmission, lifting mood. There you are, speculation!I suffer from treatment resistant Dysthymia, with an added major severe episode on top (`double depression`).
I recently saw a specialist in `difficult to treat depression`, who is starting me on a new med combination:
Venlafaxine (Efexor)/Mirtazapine (Zispin/Remeron)/Lamotragine (Lamictal)
Has anyone been on this combo (or has heard of it)?
With what results?
Cheers,
Anna
Posted by warrior on May 5, 2001, at 19:48:35
In reply to Re: Dysthymia/Treatment Resistant Depressions, posted by sweetmarie on April 5, 2001, at 7:58:07
> > > In November of last year a miracle happened which was the augmentation of Prozac with Naltrexone..... However, nobody has been able to give me a hint as to why this combination should work. Can anyone speculate about this? Wayne
> >
> > OK big guess coming up! There is cross - talk between Opiate systems and Noradrenergic systems - it MAY be (wild guess) that naltrexone operating through the opiate system somehow activates noradrenergic transmission, lifting mood. There you are, speculation!
>
> I suffer from treatment resistant Dysthymia, with an added major severe episode on top (`double depression`).
>
> I recently saw a specialist in `difficult to treat depression`, who is starting me on a new med combination:
>
> Venlafaxine (Efexor)/Mirtazapine (Zispin/Remeron)/Lamotragine (Lamictal)
>
> Has anyone been on this combo (or has heard of it)?
>
> With what results?
>
> Cheers,
>
> AnnaAnna,
How are you doing with your current medication regime? I too am "Dysthymic" and have been diagnosed as having possibly "Double Depression".
I am on Celexa 20 mg a day. I am also reading up on the latest to include Dr Burns, "Feeling Good" and whatever else I can get my hands on.
Best wishes.
Warrior
Posted by Dubya on May 5, 2001, at 23:40:11
In reply to Re: Dysthymia/Treatment Resistant Depressions, posted by warrior on May 5, 2001, at 19:48:35
I wish everybody luck against their battle with depression. I have been diagnosed with dysthmyia; although, I haven't mentioned to my 'shrink' that I have allergies. The allergies cause me to have swollen eyes and a runny nose every single day. Well, every single day until I took the anti depressants in Jan 2001. Until Mid Feb 2001, I had been taking Claritin/Clartin Extra and Flonase spray for the past 15 years (I'm 20 now). Since then, I was able to withdraw the allergy meds but, again, my allergies are flaring up again (MAY 2001-Spring in Toronto). I used to feel helpless b/c even with the allergy meds,I've tried so many meds to no success; I was still stuffed up. So from FEB-MAY 1st, 2001, I've been allergy free. Now I am taking allergy meds again. My allergy meds are over the counter (Claritin reg & extra) ones as recommended by my previous family doctor. I feel 'doomed' again. PErhaps, my allergies are partly responsible for my dysthmyia, in addition to social factors. Please suggest somebody if this makes sense?
Posted by ccass on May 6, 2001, at 9:21:59
In reply to Re: Dysthymia/Treatment Resistant Depressions, posted by Dubya on May 5, 2001, at 23:40:11
> I wish everybody luck against their battle with depression. I have been diagnosed with dysthmyia; although, I haven't mentioned to my 'shrink' that I have allergies. The allergies cause me to have swollen eyes and a runny nose every single day. Well, every single day until I took the anti depressants in Jan 2001. Until Mid Feb 2001, I had been taking Claritin/Clartin Extra and Flonase spray for the past 15 years (I'm 20 now). Since then, I was able to withdraw the allergy meds but, again, my allergies are flaring up again (MAY 2001-Spring in Toronto). I used to feel helpless b/c even with the allergy meds,I've tried so many meds to no success; I was still stuffed up. So from FEB-MAY 1st, 2001, I've been allergy free. Now I am taking allergy meds again. My allergy meds are over the counter (Claritin reg & extra) ones as recommended by my previous family doctor. I feel 'doomed' again. PErhaps, my allergies are partly responsible for my dysthmyia, in addition to social factors. Please suggest somebody if this makes sense?
Ask your family doc to give you a prescription for nasacort, its a nasal spray that you take daily it has done wonders for me.
Posted by PattyG on May 6, 2001, at 9:43:23
In reply to Re: Dysthymia/Treatment Resistant Depressions, posted by Dubya on May 5, 2001, at 23:40:11
Wow! Can you post some info about the nasal spray for depression? I've not heard of it - is it new?
Posted by BarbaraCat on January 5, 2002, at 17:54:45
In reply to Re: opioid agonist/antagonist discussion mailing list, posted by JohnB. on April 22, 1999, at 1:32:05
Please add me to the opiate/naltrexone list. I'm having many questions about WHY an opiate antagonist would work? My history is extreme refractory depression. I'm currently on 45 mg. of Remeron, 100 mg lithium as augmentor. I'm not suicidal, but have no sense of inner joy that Wayne reports (bless you, Wayne and may you dance forever in this gift of grace). I always feel good with opioids (just a little, not a gluttonous amount), so much so that I get an energetic buzz, want to clean the house (get same burst of energy from the very occasional hit of marijuana, BTW). I also crash the next day and feel awful, as though I've used up my slim allotment of 'feel-good' chemicals. This says to me that there's a dump of dopamine going on. So why would an opioid antagonist create a similar effect? Also someone mentioned ACTH dump re dopamine. Would supplementation with an acetylcholinergic (phosphatidylcholine, lecithin, etc.) go down this pathway?
Posted by stjames on January 5, 2002, at 20:17:56
In reply to Re: opioid agonist/antagonist discussion mailing list, posted by BarbaraCat on January 5, 2002, at 17:54:45
Do a search for this list, I think it is on yahoo groups. You will have to subscribe from its homepage and not here.
james
Posted by Elizabeth on January 6, 2002, at 22:04:58
In reply to Re: opioid agonist/antagonist discussion mailing list, posted by stjames on January 5, 2002, at 20:17:56
> Do a search for this list, I think it is on yahoo groups. You will have to subscribe from its homepage and not here.
The list has been dead for a while, but if people are interested I can start it up again.
-elizabeth
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