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Re: opioid agonist/antagonist discussion mailing list

Posted by BarbaraCat on January 5, 2002, at 17:54:45

In reply to Re: opioid agonist/antagonist discussion mailing list, posted by JohnB. on April 22, 1999, at 1:32:05

Please add me to the opiate/naltrexone list. I'm having many questions about WHY an opiate antagonist would work? My history is extreme refractory depression. I'm currently on 45 mg. of Remeron, 100 mg lithium as augmentor. I'm not suicidal, but have no sense of inner joy that Wayne reports (bless you, Wayne and may you dance forever in this gift of grace). I always feel good with opioids (just a little, not a gluttonous amount), so much so that I get an energetic buzz, want to clean the house (get same burst of energy from the very occasional hit of marijuana, BTW). I also crash the next day and feel awful, as though I've used up my slim allotment of 'feel-good' chemicals. This says to me that there's a dump of dopamine going on. So why would an opioid antagonist create a similar effect? Also someone mentioned ACTH dump re dopamine. Would supplementation with an acetylcholinergic (phosphatidylcholine, lecithin, etc.) go down this pathway?


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poster:BarbaraCat thread:4588
URL: http://www.dr-bob.org/babble/20020103/msgs/88902.html