Posted by btnd on October 12, 2003, at 18:38:18
In reply to Re: ok so who is knowledgeable about meth? » silmarilone, posted by BarbaraCat on September 6, 2003, at 12:37:08
> Its primary action is to release the stores of dopamine into the synaptic cleft. There is no reuptake mechanism as with SSRI's, so when the dopamine is used up, the natural stores are depleted and each successive dose is like beating a dying horse.
At doses prescribed for ADHD (Adderall 20-30 mg) there is no DRI involved, just the release of newly synthesized norepinephrine and dopamine. But once you go higher on the scale, and start using "recreational" amounts - amphetamines become potent NRIs and DRIs (mainly NRI).
> It's an amazingly addictive drug, mostly because of the horrible, awful coming down that impels you to take more just to keep the black depressions at bay.
You can use GHB during the comedown from methamphetamine - it does wonders and is much much healthier on your body that another bump. Actually it is beneficial, because at a dose of 4g GHB you get immediate increase in dopamine production, which was depleted during the meth usage. Not to mention other GHB's positive health effects as a recreational drug and a medicine tool.
And also, I'm kinda stunned - why aren't people mentally addicted to amphetamines (I'm not talking particularly of you, just from what I've noticed on the boards), trying to find the cause or remedy to block increasing tolerance of amphetamines and decrease as much as possible neurotoxicity. Those 2 things which I mentioned are covered by few simple and easily obtainable drugs. I'll post more in few days, or you can use search on "NDMA antagonist" "NDMA DXM" "NDMA L-Theanine", if you're interested.