Posted by SLS on April 3, 2010, at 10:23:38 [reposted on April 3, 2010, at 14:58:48 | original URL]
In reply to Re: OCPD and overactivity of dopamine D2/D3 receptors, posted by sukarno on April 3, 2010, at 9:34:28
What have you found in your research regarding the use of Zoloft to treat OCPD? Is there any precedent to support this strategy?
- Scott----------------------------------------------
High-Dose Sertraline Strategy for Nonresponders to Acute Treatment for Obsessive-Compulsive Disorder: A Multicenter Double-Blind Trial
Ninan PT, Koran LM, Kiev A
J Clin Psychiatry
vol. 67, 15 - 22, 2006
view at publisher
AbstractObjective:
To evaluate the efficacy and safety of high-dose sertraline for patients with obsessive-compulsive disorder (OCD) who failed to respond to standard sertraline acute treatment.
Method:
Sixty-six nonresponders to 16 weeks of sertraline treatment who met DSM-III-R criteria for current OCD were randomly assigned, in a double-blind continuation phase of a multicenter trial, either to continue on 200 mg/day of sertraline or to increase their dose to between 250 and 400 mg/day for 12 additional weeks. Efficacy measures included the Yale-Brown Obsessive Compulsive Scale (YBOCS), the National Institute of Mental Health Global Obsessive Compulsive Scale (NIMH Global OC Scale), and the Clinical Global Impressions-Severity of Illness and -Improvement (CGII) scales. Data were collected from July 26, 1994, to October 26, 1995.
Results:
The high-dose (250-400 mg/day, mean final dose = 357, SD = 60, N = 30) group showed significantly greater symptom improvement than the 200-mg/day group (N = 36) as measured by the YBOCS (p = .033), NIMH Global OC Scale (p = .003), and CGI-I (p = .011). Responder rates (decrease in YBOCS score of ≥ 25% and a CGI-I rating ≥ 3) were not significantly different for the 200-mg/day versus the high-dose sertraline group, either on completcr analysis, 34% versus 52%, or on endpoint analysis, 33% versus 40%. Both treatments showed similar adverse event rates.
Conclusion:
Greater symptom improvement was seen in the high-dose sertraline group compared to the 200-mg/day dose group during continuation treatment. Both dosages yielded similar safety profiles. Administration of higher than labeled doses of selective serotonin reuptake inhibitors may be a treatment option for certain OCD patients who fail to respond to standard acute treatment.
poster:SLS
thread:942019
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/942025.html