Posted by mtdewcmu on January 2, 2010, at 10:55:44
In reply to Re: 5HT Receptors, posted by Brainbeard on July 29, 2009, at 16:13:22
> Hello there,
> Answering your real question is too difficult for me without tedious research, but..
> I've been on Seroxat too. The withdrawal was so bad that I promised myself never to take an SSRI anymore. Still, seversal years later, my p-doc pursuaded me to try fluvoxamine (Luvox). It was a completely different SSRI! I have also tried clomipramine and Prozac, and am on sertraline (Zoloft) now. I have learned meanwhile that the SSRIs are actually drugs with very different chemical profiles if you go into the details. They all do SRI, but after that, the roads depart. This is why trying another SSRI can always help.
> An attempt at summarizing the different pharmacological and experiential profiles:
> * paroxetine/Seroxat/Paxil: strong SRI, also anticholinergic effects (dry mouth!) and H1-antagonism; some affinity for dopamine receptor and also noradrenergic effects; both sedating and activating, can induce (hypo)mania; of all the SSRIs the most likely to induce weight gain in the long term
> * fluvoxamine/Luvox: stronger affinity for 5HT3-receptor, which means more initial nausea but more eventual anti-anxiety and anti-OCD (at least in theory..); most sedating of the SSRIs.
I'm not sure what you mean by this. Do you mean that Luvox directly interacts with the 5-HT3 receptor? Or that somehow it interacts more strongly with the 5-HT transporter at synapses with 5-HT3 receptors?