Posted by Brainbeard on September 16, 2009, at 13:06:04
In reply to Re: imipramine ) Inhibition of 5-HT Uptake Pump (%) » Brainbeard, posted by sowhysosad on September 16, 2009, at 11:54:19
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> http://www.preskorn.com/books/omd_s6.html
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> Figures 6.3 and 6.4 on that page.I can't find the potency data for imipramine anywhere on the page!
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> A lot of people claim escitalopram causes the least [sexual dysfunction] but - in line with your reasoning - some data show it's a fairly weak (but very selective) SRI.Well, I think you mean citalopram (Celexa) - that indeed is a rather weak SSRI. Escitalopram (Lexapro) on the other hand is truly the most selective and potent SSRI. I suspect that claims about less sexual side-effects are the result of marketing hype and myth-building rather than an accurate representation of reality. Since escitalopram is the strongest SSRI, it is bound to have the strongest serotonergic side-effects, i.e. the worst sexual dysfunction of all SSRI's.
(People sometimes forget, while scapegoating the SSRI's, that the older tricyclic clomipramine, which is a highly potent SRI, also is able to cause big time sexual dysfunction. Clomipramine was worse in this regard for me than any SSRI I've been on.)There are forum discussions supportive of my reasoning that Lexapro should rather be worse than better when it comes to sexual dysfunction: http://www.drugs.com/forum/featured-conditions/longterm-lexapro-sexual-side-effects-33868.html (beware, this discussion has a wild tale about Lexapro lingering in the liver for more than a year - hilarious!); http://www.topix.com/forum/drug/lexapro/TD58CPM2FST9IN7NM; http://www.dr-bob.org/babble/20040412/msgs/336801.html...
poster:Brainbeard
thread:909605
URL: http://www.dr-bob.org/babble/neuro/20090701/msgs/917363.html