Posted by Brainbeard on June 27, 2009, at 5:24:38
In reply to Re: Can serotonin reuptake inhibition be countered?, posted by morganpmiller on June 27, 2009, at 2:31:49
Indeed, the anecdotal evidence certainly points to pro-dopaminergic action of sertraline even at moderate doses. Sertraline has shown to improve cognitive and psychomotor function in older parkinson patients. But technically, this can hardly be due to sertraline's extremely weak dopamine reuptake inhibition at such doses. Check the 'Is sertraline an inhibitor of dopamine uptake?' section of this column by Dr. Preskorn: http://www.preskorn.com/columns/9909.html
So I wonder if sertraline might have some other, yet unknown dopaminergic mechanism.
By the way, I found a partial answer to my own question: the main side-effect of over-saturated serotonin receptors, namely diarrhea, can be countered by adding a constipating TCA (preferably a non-SRI...).