Posted by Brainbeard on June 17, 2009, at 4:25:51
Sertraline (Zoloft) is a weak dopamine reuptake inhibitor (DRI). To get significant DRI, one would have to take high doses, possibly higher than the highest recommended dose (which is about 250mg). Since there are hardly any clean DRIs available, I was wondering if there is any way that sertraline's serotonin reuptake inhibition (SRI)could be countered or mitigated, so that one could take a higher dose of the drug without getting SRI overkill? The only thing I can think of is that perhaps tianeptine, which accelerates the reuptake of serotonin instead of inhibiting it, might work. But tianeptine doesn't grab the sert transporter, I guess, so perhaps the working mechanisms are too different. There has been a report of a woman on tianeptine who became depressed after adding paroxetine, but that doesn't tell us much.
Any ideas? Or might there be, more indirectly, (pharmacological) ways to mitigate the side-effects of serotonin receptor saturation?
All feedback appreciated, negative included.