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Re: memantine for anhedonia? g_g_g_unit

Posted by SLS on May 12, 2009, at 6:28:18

In reply to memantine for anhedonia?, posted by g_g_g_unit on May 12, 2009, at 2:51:25

> i have a concern which was sparked by a meeting with my GP today, in which i informed him that i was trialing Memantine. he said that i did not seem to present the characteristics of glutamate overactivity

How does he determine this?

> (which would conventionally call for him to prescribe Neurontin);

Or, and especially, Lamictal.

> if anything, given my persistent anhedonia, faltering memory, etc. he thought it might be a case of the opposite.

Are you bipolar?

I am not sure that memantine by itself is helpful for anhedonia. I know that lamotrigine is. As I am now taking memantine for nearly 4 weeks, I believe that I am benefiting from it, but anhedonia is not among the symptoms that it is helping with. I have more energy and motivation, and some improvement in cognitive impairment.

I am trying to sell the idea to my doctor that a three-pronged attack against hyperglutamatergic activity would include:

1. lamotrigine: GLU release inhibition
2. memantine: GLU (NMDA) receptor antagonism
3. topiramate: GLU (AMPA/kainite) receptor antagonism.

Each drug operates on glutamatergic neurotransmission through distinctly different mechanisms.

By the way, how does gabapentin act as an antiglutamatergic?

Thanks.


- Scott

 

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poster:SLS thread:895324
URL: http://www.dr-bob.org/babble/neuro/20090129/msgs/895331.html