Posted by SLS on August 29, 2008, at 19:36:01
In reply to MAOI and NARI interaction, posted by britney 27 on August 29, 2008, at 17:00:41
> Does anyone know whether it is safe to combine reboxitine (NARI) with an MAOI (tranylcypromine) and if so what are the effects?I am not sure.
> There is little research in combining the two drugs together.
I don't think there is any formal research at all. You might have to trust the anecdotal reports written up.
> Some websites say they are to be avoided but do not give a reason and others say they make an effective combination because the NARI offsets the potential hypertensive crises due to an interaction of MAOI with tyramine.
I'm not sure reboxetine is safe. There are theories that suggest it should be. Nothing more. There seems to be a notion that any selective NE reuptake inhibitor will prevent a hypertensive crisis from occurring by preventing the uptake of tyramine into the neuron and avoiding the displacement of NE in the synaptic vesicles.
> I want to experiment and combine them to see if they give me an optimal boost in energy, motivation and drive.I found desipramine and nortriptyline to be compatable with high-dosage Parnate. If you were to proceed with adding a NRI, I would suggest taking your blood pressure periodically at the initiation of treatment. Be careful, though, to take into consideration that Parnate monotherapy has triggered a hypertensive reaction in the absence of any other drug.
I guess I would feel more comfortable trying one of the two TCAs first. I have no doubt that they can be safe in combination with Parnate. With reboxetine, you might not find any anecdotal data suggesting its safety. I like nortriptyline precisely because it is not selective in its receptor binding properties. For instance, it can block 5-HT2a receptors, something found with drugs like Remeron and antidepressant atypical antipsychotics.
If you find anything persuasive, please post your findings.
Thanks.
- Scott
poster:SLS
thread:849082
URL: http://www.dr-bob.org/babble/neuro/20080706/msgs/849103.html