Posted by BrightEyed+Blueberry on July 4, 2008, at 13:51:32
In reply to Re: Interesting excerpt from this paper about apat, posted by undopaminergic on May 28, 2008, at 11:05:19
Can anyone send me the actual text or pdf of the full journal article, or is that a "no-no"?
Are we not allowed to post journal articles that otherwise people who don't have access to (other than the abstract) would have to pay for? Do you know? Expensive and I'm not a doctor/scientist....
Thanks,
Bright
------Interesting excerpt from this paper about apathy
Posted by rgb on May 25, 2008, at 5:42:24
Interesting excerpt from this paper about apathyPosted by rgb on May 25, 2008, at 5:42:24
"(...) In other instances, clinically sig-
nificant apathy may not be evident until dysphoric and
vegetative symptoms have improved with antidepres-
sant treatment. Residual symptoms of motivational loss,
such as anergy, lack of drive, or lack of initiative, may
prevent return of full function after treatment of de-
pression. It is well recognized that patients with such
symptoms may benefit decisively from adding methyl-
phenidate or dextroamphetamine.31,32 (...)"Source: http://neuro.psychiatryonline.org/cgi/content/abstract/7/1/23
--------------------------------------------------
> > > I've been free from the dysphoric symptoms of depression for a very long time, but the apathy has been really challenging to treat. A major problem is that it's rather difficult for an apathetic person to take the all the actions that may be needed to find effective treatment.
> >
> > How might Abilify affect your apathy? I was thinking that stimulating postsynaptic DA receptors plus blocking 5-HT2a receptors might offer some benefit. From what other people have told me, they become more motivated on Abilify. This is true with me as well.
> >
>
> I had some really great, but intermittent, results with pramipexole, and it did improve motivation among other things. However, I had some rather dramatic side-effects too that were also intermittent: blacking out and almost losing consciousness, probably due to hypotensive attacks. Within a couple of weeks or so, all benefits were lost to tolerance, as usual. Pramipexole is probably the most anti-anhedonic agent I've ever tried, and occasionally effected a state of well-being, which was far from euphoria, but greatly enhanced enjoyment of life.
>
> For motivation, I think sulpiride had the most powerful effect of anything I've tried, although it is rivalled by amantadine, which was effective only in one of many trials. Needless to say, tolerance eliminated most - or all (in the case of amantadine) - effects of these drugs as well.
>
> My impression from drugs that block serotonin 5-HT2A receptors - including at least risperidone, mirtazapine and cyproheptadine - is that the results are not particularly impressive. Unfortunately, all 5-HT2A antagonists currently available clinically are very dirty drugs - it would be interesting to try some of the more selective research chemicals to better elucidate the role of this recepor.
>
> 5-HT2C-receptor antagonists, on the other hand, may be of somewhat greater interest. At some point, I may try agomelatine, or alternatively, one or more of several research compunds that are highly selective for 5-HT2C, and which have been shown to enhance VTA - but not SN - DA firing in animals.
>
> Fortunately, my current motivational situation looks brighter than it has for a long time due to the addition of buprenorphine, and as long as its efficacy is sustained (or enhanced), the quest for new treatments to try is of diminished urgency.Interesting excerpt from this paper about apathy
Posted by rgb on May 25, 2008, at 5:42:24
"(...) In other instances, clinically sig-
nificant apathy may not be evident until dysphoric and
vegetative symptoms have improved with antidepres-
sant treatment. Residual symptoms of motivational loss,
such as anergy, lack of drive, or lack of initiative, may
prevent return of full function after treatment of de-
pression. It is well recognized that patients with such
symptoms may benefit decisively from adding methyl-
phenidate or dextroamphetamine.31,32 (...)"Source: http://neuro.psychiatryonline.org/cgi/content/abstract/7/1/23
poster:BrightEyed+Blueberry
thread:831008
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/838006.html