Posted by undopaminergic on May 24, 2008, at 16:31:12
In reply to Re: Sulpiride and Abilify questions... » undopaminergic, posted by SLS on May 23, 2008, at 15:45:11
> > > > I think aripiprazole (Abilify, APZ) is regarded as a full agonist at presynaptic dopamine (DA) (auto)receptors. This reduces DA synthesis and release, and is likely to be contrary to what you're looking for.
> > >
> > > Not necessarily. One must look at all of the properties of aripiprazole.
>
> > Right, so why do you quote - out of context - only one part of a message that looks at the properties most relevant to predicting how it will it will interact with sulpiride?
>
> Feel free to post the entire article. You can use the link I provided.
>I was referring to your quotation of my message, not the aripiprazole article.
> > > Postsynaptic agonists overule presynaptic agonists because they directly stimulate postsynaptic receptors regardless of the decrease in DA synthesis and release.
>
>
> > That is dose dependent.
>
> No. It is DA concentration dependent. I thought the article was clear about that. This is a well known property of this drug.
>Both agonist concentration and endogenous DA tone are (almost certainly) of significance, and the article does not contradict that. In any case, I was not referring to APZ exclusively, but to other agents as well.
poster:undopaminergic
thread:829749
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/830917.html