Posted by undopaminergic on May 23, 2008, at 15:37:34
In reply to Re: Sulpiride and Abilify questions..., posted by SLS on May 23, 2008, at 8:13:38
> > I think aripiprazole (Abilify, APZ) is regarded as a full agonist at presynaptic dopamine (DA) (auto)receptors. This reduces DA synthesis and release, and is likely to be contrary to what you're looking for.
>
> Not necessarily. One must look at all of the properties of aripiprazole.
>Right, so why do you quote - out of context - only one part of a message that looks at the properties most relevant to predicting how it will it will interact with sulpiride?
> Postsynaptic agonists overule presynaptic agonists because they directly stimulate postsynaptic receptors regardless of the decrease in DA synthesis and release.
>That is dose dependent. At low doses of sulpiride/amisulpride and dopamine direct agonists, the presynaptic effects predominate.
poster:undopaminergic
thread:829749
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/830740.html