Posted by Larry Hoover on July 21, 2007, at 18:17:21
In reply to Re: SPLENDA - EXPOSED » Larry Hoover, posted by Phillipa on July 21, 2007, at 14:40:47
> Lar what do you think of snoops.come. It says this is all untrue?????Love Phillipa
Snopes has reasonable analyses of the issues which I reviewed. I posted an abstract of mood effect, and I stand by that concern. But, I cannot find any evidence implicating aspartame in e.g. lupus or MS.
I disagree with the contention that aspartame is fully hydrolyzed in the gut, however. (See snopes link to http://www.aspartame.net/rumors/Aspartame_and_the_Internet.asp) The dipeptide could easily be absorbed intact, and it could very well influence receptors. Four and five amino acid chains are highly active at opioid receptors, so I wouldn't arbitrarily deny the possibility that a dipeptide could agonize, antagonize, or inhibit a receptor site.
If a person discovers a consistent effect (e.g. the migraine trigger), then I believe it, notwithstanding anything in the medical literature.
When I contacted the Nutrasweet Company about the mood issue, they sent me an entire volume of the journal Regulatory Toxicology and Pharmacology (35(2)), entitled 'Aspartame: Review of Safety'. In it, they dismissed the Walton et al mood study *because* it had been prematurely terminated due to the adverse effects, claiming that it was impossible to derive any meaning from the study. In contrast, the authors dismiss as irrelevant the finding that a significant change in plasma concentration and exposure to beta-endorphin occurs after aspartame exposure.
I have never taken the time to fully analyze this volume of research, but it is telling that the lead authors are scientists under the direct employ of Nutrasweet, and all main research was funded by them (or the parent, Monsanto). Without even knowing that, the bias is evident.
Lar
poster:Larry Hoover
thread:770960
URL: http://www.dr-bob.org/babble/health/20070701/msgs/771017.html