and a few more (piracetam and hydergine)

Posted by zefdie on June 15, 2006, at 5:57:37

In reply to nootropics as antidepressants: does research exist, posted by zefdie on June 15, 2006, at 4:05:24

Again, apologies for my unscientific, scattershot PubMed searches, especially if this is all tremendously rendundant or irrelevant stuff, or if no one wants to read it. I'm finding it pretty interesting (though I'm too tired to tie anything together). Also, apologies if they aren't links! I notice that html is disabled here? Anyway....
Changes in the brain biogenic monoamines of rats, induced by piracetam and aniracetam:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=6535371
[Effect of centrophenoxine, piracetam and aniracetam on the monoamine oxidase activity in different brain structures of rats]:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3137089
Effect of piracetam, a nootropic agent, on rat brain monoamines and prostaglandins.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2606534
(Is it common for a drug as old as piracetam to show study after study on rats and not people? Sheesh.)
Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11959085
Brain neurotransmitter receptor binding and nootropic studies on Indian Hypericum perforatum Linn:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12164263
Interaction of piracetam with several neurotransmitter receptors in the central nervous system. Relative specificity for 3H-glutamate sites:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3002398
This one is very interesting and addresses the age-contingent effects of various nootropics:
Biogenic monoamine uptake by rat brain synaptosomes during aging. Effects of nootropic drugs.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7835648
Evidence that piracetam has an anxiolytic action:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=95599
1: Act Nerv Super
Effect of piracetam on central serotoninergic processes.
Allikmets LH, Rago LK, Otter MJ.
(No abstract)
Other searches turn up studies of leviracetam (Keppra) and bipolar disorder.
Hydergine:
Dopamine receptor profile of co-dergocrine (Hydergine) and its components:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=6297930
Ergot alkaloids and central monoaminergic receptors:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3005775
Co-dergocrine (Hydergine) regulates striatal and hippocampal acetylcholine release through D2 receptors:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7911040
There is apparently no abstract for this, but it sounds interesting:
[Hydergine in the treatment of chronic psychoses]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=4964710
It's a French study.
One consitent thread through many of these is a contention that hydergine only has mood-enhancing properties on older people.
Eh, I'm tired.

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nootropics as antidepressants: does research exist zefdie 6/15/06
another article abstract zefdie 6/15/06
and a few more (piracetam and hydergine) zefdie 6/15/06
Re: nootropics as antidepressants: does research e Declan 6/16/06
Re: nootropics as antidepressants: does research e zefdie 6/16/06

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