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Re: THIS is the study I was looking for !!!!

Posted by linkadge on June 22, 2005, at 18:54:15

In reply to Re: THIS is the study I was looking for !!!! » linkadge, posted by Chairman_MAO on June 22, 2005, at 15:59:50

"One ubiquitous indicator of an AD effect is downregulation of beta adrenoreceptors."


I am not posative of that. I read a study that said that citalopram had no effect on beta-adrenoreceptor function. I have been looking for the past hour to find data on SSRI's and beta adrenoreceptor function but I have found none. Can you find any studies on SSRI's and adrenoreceptors?

Actually, I am starting to believe that AD effects are more due to a regional regulation of NMDA function. See:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9770644&dopt=Abstract


I think that the NMDA effect of citalopram in the amygdala reflects its efficacy in panic.


I believe that 5-ht1a agnonism is sufficiant to downregulate the 5-ht2a receptors.

But this study seems to suggest that adrenoreceptor activation can also regulate the 5-ht2 system.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8788498&dopt=Abstract

This page is interesting too.

http://biopsychiatry.com/5ht2.htm


Also from:

http://www.preskorn.com/books/omd_s6.html

A general rule in clinical psychopharmacology is that the brain adapts to the presence of drugs. For example, uptake inhibitors produce downregulation of the receptors for the specific neurotransmitter whose uptake pump has been inhibited (eg, some serotonin receptors in the case of serotonin uptake inhibitors and beta-adrenergic receptors in the case of norepinephrine uptake inhibitors).17 In fact, such downregulation has been postulated to mediate the antidepressant efficacy of these drugs.

Such downregulation likely also mediates the withdrawal syndromes that can be seen when some of these antidepressants are abruptly stopped. Anticholinergic withdrawal syndrome can be seen when high-potency muscarinic cholinergic receptor blockers (ie, TATCAs) are abruptly stopped. The symptoms of anticholinergic withdrawal syndromes (sometimes called "cholinergic rebound") are listed in Table 6.12

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Perhaps, in the case of parnate, the higher doses have more effect on serotogenic function leading to adaptation of this system as well. Nardil might lead to 5-ht downregulation at more clinical doses as it seems to be a litte more serotogenic.

If the elevated receptor densisties are reflective of a relative absence of that particular neurotransmitter, then it stands to reason that an effective antidepressant for you, would be the one that leads to a normalization of the system.

I stand to be corrected however.


Linkadge


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URL: http://www.dr-bob.org/babble/alter/20050612/msgs/517207.html