Posted by Elroy on April 21, 2005, at 20:59:30
In reply to Arghhh, posted by gromit on April 20, 2005, at 18:09:17
I think that you should print off some of the studies done on LOW DOSE selegiline and how it is NOT dangerous and how it is NOT an MOA-A inihibitor at those low levels (really anything below 15-20 mg daily).
QUOTE: "L-deprenyl is what good pharmaceuticals are all about. First it is exceptionally safe, second it protects and enhances mental function, mood and even libido, thirdly, it may even extend life. Imagine a safe agent that enhances both the quality and length of life." - Julian Whitaker M.D. - Health and Healing Newsletter, Whitaker Wellness Institute, Newport Beach, California. END QUOTE
QUOTE: Similarly, Birkmayer et al. reported benefit in an uncontrolled study in 102 outpatients and 53 inpatients with unipolar depression who received selegiline hydrochloride 5 to 10 mg daily in association with phenylalanine 250 mg daily- about 70% of these patients, in whom conventional antidepressants were not effective, were reported as having complete remission. END QUOTE
It sounds to me like he is listening primarily to a Big Pharm sales rep.
Maybe challenge him to provide the documentation / reviews / studies that shows selegiline to be dangerous at those levels LOW DOSE levels... combined with ANYTHING...
Even higher doses used in Parkinson cases are quite safe:
Heck, if it is dangerous - provably dangerous - at low dose levels - then I'd sure like to know the criteria showing that BEFORE my psych docv starts me on that. She's concerned that my levels of NE are so low and is looking at selegiline - along with either tyrosine or DLPA - to very gradually boost those levels back up. But if he's got documentation as to it's safety levels, well, I'd sure as heck like to know about them!
Anyway, would caution with Cymbalta (or Effexor) as both are known to create urinary tract inflammation or prostatitis type sensation problems. I had severe immediate reaction in that regard with Effexor and then with Cymbalta had similar reactions - just that Cymbalta took about ten days to manifest instead of just a couple days like with Effexor.
I'd compare this symptom list - for Cymbalta - with LOW DOSE selegiline....
> > So 10 mg of selegiline + 5 mg T patch daily is the best thing I've tried, my mood has not really improved but I do feel more focused and much better physically.
> Gee, maybe I shouldn't have said anything. Today my doctor decided that it was unsafe to add anything to even 5 mg selegiline. He wanted to put me on prozac + zyprexa, like I need to be any more sleepy! We settled on 60 mg cymbalta and possibly adding an amphetamine later. This is supposed to be a less dangerous route than selegiline + whatever else? I feel like I'm the sane one and my doctors are nuts...