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RE: PEA Elroy

Posted by Larry Hoover on April 14, 2005, at 8:40:18

In reply to RE: PEA Larry Hoover, posted by Elroy on April 9, 2005, at 21:56:05

> Some excellent info there.


> Can easily see where Taurine would help with anxiety.

It works for me. At least I can say that with 100% assurance.

> Wonder how it would work with peripheral neuropathy type pains like Neurontin does?

Gabapentin's role in suppressing pain associated with peripheral neuropathy has finally been sorted out. It hits a very specific spinal cord receptor, the alpha2-adrenoceptor (with specific subunits that I forget).

The spinal cord used to be thought of as something analogous to a telephone trunk line; nothing more than a bundle of parallel cables, and distribution network to the various peripheral tissues.

We now know that the spinal cord processes signals all by itself. It then makes a decision (a threshold is crossed or not) to notify the brain. Spinal processing is completely independent of the brain. There can be what are essentially feed-back loops that hyper-sensitize the peripheral nerves to pain stimuli.

You know what happens when you get a live microphone too near the speakers (or the volume is set too high) get that feedback screech. That's what happens to peripheral nerves, they go into spinal feedback overload.

Gabapentin breaks the feedback loop.





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