Posted by Elroy on March 26, 2005, at 13:42:33
In reply to RE: Segeline (Deprenyl) and phenyalanine » Elroy, posted by Larry Hoover on March 26, 2005, at 11:42:52
Well, what I have found - with the Dr. Bib protocol or whatever - is that the DLPA or even LPA tends to make my anxiety and certain physical symptoms qute worse. Physical symptoms such as a UTI or semi-prostatitis type pain. My urologist thinks that I have an over-production of adrenaline (NE and so forth) and that it is not only causing the severe anxiety, but also the flare-ups of the UTI type symptoms and some other "evil effects"... and that any supplement that I take that greatly increases NE (etc.) just worsenes things.
Interesting....
And, yes, I caught those same errors on the Dr. Bib web site. With SAMe - and I also believe with TMG - is pretty necessary to take th B vites...
Interestingly, the Deprenyl by itself (5 mg dose) did NOT have that same effect, only when I took it with the DLPA or even just the LPA... so then I wondered about just the "D" version? I wonder if it would have lessened effects on increasing NE, etc. as (I believe) it is mostly converting to PEA???
Then I got to thinking....
My primary problem is ANXIETY - not depression. And here I am getting caught up - like most pscyh docs - in looking at ADs to address an anxiety problem. I actually have very little depression - other than the ocasional depression at being ticked off at my continuing physical / emotional state!
I had a somewhat "unique" situation occur where I had developed anxiety problems (after several years of stress related to work stress in a whistleblower environment and a subsequent whistleblower lawsuit) for about 18 months or so (July 2002 to early February 2004) and then everything cleared up. The anxiety was mostly on-again and off-again and mild to moderate with occasionals ever episode - but even then not extremely so.
And then in June of 2004 the anxiety returned much, much worse and remained constant - and seemed to just worsen week by week. Within just 2 - 3 weeks I had the following physical symptoms quickly appear - and with severe ysmptoms almost immediately, no "build up": hypogonadism, UTI or prostatitis type pains (but no infection ever found), tinnitus, and peripheral neuropathy type pains in hands and (especially) feet - plus some other minor symptoms. No significant problems in any of those areas prior to then.
No depression (other than the occasional normal depression at my continuing state of condition), but severe on-going anxiety.
Last September I was found to have extremely high cortisol levels but anti-cortisol supplements have done a nice job in bringing those levels back down (still elevated, but now just above normal). In September my cortisol levels were almost SIX times the maximum end of the normal reference range! Unknown what they were in June (took a while to get an ENDO to do the desired testing, but I suspect was even much higher. Was some initial concerns as to having Cushing's, but that was eliminated with numerous advanced testings.
Levels stayed high until late September when I was put on 1st anti-anxiety med (Ativan) when they came down a little bit. When I was switched over to Xanax XR they came down another noticeable chunk (but still prety high). The big ddecreases started after a regimen of taking strong anti-cortisol products (only after Cushing's was eliminated).
Interestingly, during the testing process, a small "lesion" (i.e., tumor) was found INSIDE my left adrenal gland. Cushing's can - of course - be caused by an adrenal gland tumor (though usually it is a pituitary gland tumor), but once Cushing's was eliminated the adrenal gland tumor was declared "incidental" and "probably not biologically active".
Now a new PCP doc that I recently hooked up with has expressed some strong reservations about that adrenal gland tumor. He pointed out that being inside the gland that it is probably affecting the adrenaline secretion as that's where it occurs in the adrenal gland, in the medulla or inner layer. His suspicions - at this point - is that the adrenal gland tumor may have caused the severe anxiety and some of the physical symptoms and somewhere along the way the HPAT Axis obviously broke down and the lowered testosterone production and the the super high cortisol output was part of the body's reaction to that...
So.....
A whole new round of (different) testing coming up. My PCP seems to think that the adrenal gand needs to come out and that then the anxiety - and subsequently a lot of the physical symptoms - will clear up. Not as convinced that theHPAT Axis will then achieve a full "re-set" or not after that...
Elroy> > Have you tried it with the protocol of taking the amino acid DLPA (DL Phenylalanine) on an empty stomach about 30 minutes before taking the deprenyl?
> >
> > As I (who am just a humble layman who reads a lot) understand it, the DL-Phenylalanine converts quite a bit into Tyrosine which converts quite a bit into L-Dopa which converts quite a bit into Dopamine which converts quite a bit into what used to be called Adrenalin (a term not so much used now as it apparently quickly breaks down into Norepinephrine and Epinephrine). What L-phenyalanine is not used in the above conversion process (if I have this right) is a direct precursor to phenylethylamine (PEA). PEA acts as an endogenous compound in the brain that promotes energy and elevates mood
>
> Close enough, but dopamine is the direct precurser to noradrenaline, which is then converted into adrenaline (sometimes called epinephrine).
>
> The advantage of DLPA over LPA with selegiline is that D-phenylalanine does not fit into the enzyme that converts phenylalanine to tyrosine. It does, however, fit into the enzyme that decarboxylates phenylalanine into PEA. So, half the DLPA dose (i.e. the DPA) can only go to PEA, and a little bit of the LPA probably gets converted to PEA as well....I'd expect a roughly 55% yield of PEA from DLPA, as compared to maybe 10% yield from pure L-phenylalanine.
>
> Lar
poster:Elroy
thread:452259
URL: http://www.dr-bob.org/babble/alter/20050323/msgs/475851.html