Posted by Larry Hoover on March 26, 2005, at 11:42:52
In reply to RE: Segeline (Deprenyl) and phenyalanine » gromit, posted by Elroy on March 12, 2005, at 14:29:35
> Have you tried it with the protocol of taking the amino acid DLPA (DL Phenylalanine) on an empty stomach about 30 minutes before taking the deprenyl?
>
> As I (who am just a humble layman who reads a lot) understand it, the DL-Phenylalanine converts quite a bit into Tyrosine which converts quite a bit into L-Dopa which converts quite a bit into Dopamine which converts quite a bit into what used to be called Adrenalin (a term not so much used now as it apparently quickly breaks down into Norepinephrine and Epinephrine). What L-phenyalanine is not used in the above conversion process (if I have this right) is a direct precursor to phenylethylamine (PEA). PEA acts as an endogenous compound in the brain that promotes energy and elevates moodClose enough, but dopamine is the direct precurser to noradrenaline, which is then converted into adrenaline (sometimes called epinephrine).
The advantage of DLPA over LPA with selegiline is that D-phenylalanine does not fit into the enzyme that converts phenylalanine to tyrosine. It does, however, fit into the enzyme that decarboxylates phenylalanine into PEA. So, half the DLPA dose (i.e. the DPA) can only go to PEA, and a little bit of the LPA probably gets converted to PEA as well....I'd expect a roughly 55% yield of PEA from DLPA, as compared to maybe 10% yield from pure L-phenylalanine.
Lar
poster:Larry Hoover
thread:452259
URL: http://www.dr-bob.org/babble/alter/20050323/msgs/475788.html