Posted by KaraS on March 2, 2005, at 22:12:32
In reply to Re: SJW ok for severe depression? » KaraS, posted by Larry Hoover on March 2, 2005, at 16:43:12
> >
> > > I'm currently taking SJW and a similar dose of a tricyclic (trimipramine). I wouldn't worry about it at all.
> >
> > Thanks. You must have just started the SJW again. What brand are you taking and what dosage? I'm thinking of trying the HBC Protocols brand. Do you think that if one goes past the 900 mg. amount (or esp. if they take as much as 1800 mg.) that they'd need to watch their tyramine intake?
>
> I'm using Organika brand, 900 mg/day. It's actually not one of those kick-a$$ brands with hyperforin potency. Mild, gentle.
>
> I've no reason to think that tyramine is an issue with any dose of SJW.
>
> Did you know that an experimental protocol with SJW employed doses of 22,000 mg/day? That's not a typo. That was an AIDS trial, to determine antiviral activity (SJW does have antiviral effects in vitro). Turns out that SJW induces enzyme 3A4, which inactivated the major anti-HIV drugs, and made the SJW trial a failure. But the thing is, even that major dose was not associated with intolerable side effects.
>
> > > My arm is why I haven't been posting. It's really gone bad. I'm back on Percocet. I'm waiting for surgery. Nerve damage flaring up. I had a bad feeling about this the moment it happened. Some intuition is true.
> > >
> > > Lar
> >
> >
> > I was afraid that might be the problem. I'm so sorry to hear that. Hopefully the surgery will correct the problem. Intuition is often correct. Yours certainly was. The trouble is determining what is intuition from what is needless worrying (at least in my case).
> >
> > My thoughts are with you.
> >
> > Kara
>
> Thanks.
>
> Lar
>Thanks for the response. Good to know that you can safely take such large doses. Hope you're feeling better!
K
poster:KaraS
thread:440223
URL: http://www.dr-bob.org/babble/alter/20050225/msgs/465761.html