Re: More on Tryptophan- does illness affect efficacy?

Posted by jasmineneroli on November 19, 2004, at 17:10:25

In reply to Re: More on Tryptophan- does illness affect efficacy? » jasmineneroli, posted by raybakes on November 19, 2004, at 16:00:25

> Don't know what p450 enzymes affect tryptophan hydroxylase, but St John's Wort has a profound effect on P450s.

* Hmmmm, I'm going to have to look into it further.
> During infection or inflammation peroxynitrite inhibits tryptophan hydroxylase. Also the enzyme IDO is upregulated to break down tryptophan via the kynurenine pathway as tryptophan degradation seems to be essential to help in fighting infection. Inflammation in autistic of chronic fatigue also breaks tryptophan down into a chemical called IAG, thought to disrupt serotonin.
>
> Ray
>
>
*Thanks Ray, that makes HUGE sense, considering how I was feeling.
I don't know whether or not to increase the dosage if I become ill again at some point, to try to maintain a stable level. What do you think?
Jas

Thread

More on Tryptophan- does illness affect efficacy? jasmineneroli 11/18/04
Re: More on Tryptophan- does illness affect efficacy? » jasmineneroli raybakes 11/19/04
Re: More on Tryptophan- does illness affect efficacy? jasmineneroli 11/19/04
Re: More on Tryptophan- does illness affect efficacy? » jasmineneroli raybakes 11/20/04
Re: More on Tryptophan- does illness affect efficacy? » raybakes jasmineneroli 11/20/04
Re: More on Tryptophan- does illness affect efficacy? » jasmineneroli raybakes 11/22/04
Re: More on Tryptophan- does illness affect efficacy? yahtzee 11/22/04
Re: More on Tryptophan- does illness affect efficacy? » yahtzee jasmineneroli 11/22/04
Re: More on Tryptophan- does illness affect efficacy? » raybakes jasmineneroli 11/22/04
don't forget b12, folate and TMG with SAMe! (nm) » jasmineneroli raybakes 11/23/04

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