Posted by KaraS on November 12, 2004, at 14:46:38
In reply to Re: Sleep, etc. » KaraS, posted by Larry Hoover on November 7, 2004, at 11:23:53
> > > Your hypothesis is that you have hypersensitive DA autoreceptors. You could look at the selegiline/DLPA experiment as a test of the null hypothesis.
> > >
> > > Lar
> > >
> >
> >
> > But I have taken selegiline and it does put me to sleep. That confirms the hypothesis, no?
>
> I dunno. I don't think you did the DLPA part, right?Even without the DLPA, selegiline shouldn't put me to sleep - if those autoreceptors aren't hypersensitive.
> Sleep is a very complicated process. If you watch and listen to this flash presentation, you may get one of those intuitive aha's....
> http://www.medscape.com/viewprogram/2791?src=search
Ok, I admit it. I have no idea why you sent me that link. No intuitive ahas. No concept of how this relates to my DA autoreceptor problem.
I assume, based on other things you wrote, that I'm supposed to understand from this how selegiline might help me - but I don't see it.
> >My concern is could the continuous taking of selegiline do harm to the autoreceptors perhaps by making them more hypersensitive? I'd rather try to figure that out theoretically than empirically.
I was thinking about this all wrong. The flooding of the synapses with dopamine is exactly what I need.
> I don't know that you can. I'd wonder what led to hypersensitivity in the first place. Was it acute? Chronic? Did the situation remit/revert over time? (I.e. has the hypersensitivity gone away again?)
> I can only shrug.
>
> Lar
I too wonder what lead to my hypersensitivity? Was I born that way? Could years of SSRI usage have given me this problem? Could it have been the CFS? A combination of the all of these things? All I know is that I've had this for the past few months because over that time I've tried several stimulant type meds and supplements that have all, paradoxically, put me to sleep. I doubt it has gone away since my last recent trial but when I start on the selegiline again I will find that out. One thing I am certain of is that I will never know the answers to the questions of how long I've had this problem and what caused it.So the next step is to take measures to lessen the hypersensitivity. I think it makes sense to try the selegiline again with the DLPA this time as you have been urging. It's cheap, I tolerate it and I have all of the ingredients here at home already and if it works, I don't have to worry about the MAOI diet. My next questions to you now are:
1) The P-5-P I have also contains some B2 and 100 mg. of magnesium (in oxide and taurinate form). Is this a problem? Do I need to get pure P-5-P?
2) Can I take them DLPA, P-5-P and selegiline at the same time? (esp. if I take the selegiline sublingually) Or maybe I should take the selegiline at night ('cuz it sedates me) while taking the DLPA + P-5-P in the AM? Does it matter at all when they're taken?
3) Do you know anything about the liquid selegiline citrate? I've read that it's better than the selegiline hydrochloride pills but I have a feeling that's more of a political issue than a therapeutic one.
Thanks,
K
poster:KaraS
thread:387192
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/415097.html