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Re: Sleep, selegiline and autoreceptors » KaraS

Posted by Larry Hoover on November 25, 2004, at 5:17:17

In reply to Re: Sleep, selegiline and autoreceptors » Larry Hoover, posted by KaraS on November 21, 2004, at 14:32:24

> > Yes, your brain could have adapted to a deficiency in dopamine by becoming exquisitely autoreceptive. But again, I'm encouraging you to not close your mind on the subject. Theories are just that, theories. What else might explain your symptoms/response to meds? That should always be something being thought about, in parallel to your consideration of this one theory.
>
> Most of the other theories I've entertained so far have to do with processes around dopamine in some way. Too limiting perhaps?

Thinking itself can be too limiting. I know you don't want to waste time, or effort, but as we all know, paradoxical responses are paradoxical only with respect to thinking. They are, in fact, quite natural for the individual so responding.

> > Have you stayed on the meds for long enough to see if your body re-adapts?
>
> No, that's why I've just started trying it again. It's not easy to function on it though because it makes me sleepy during the day and then 8-9 hours later makes me feel stimulated. I will probably try taking it at night and hope that taking the DLPA in the morning will work out. If I start to change how I react to it (which is the goal) then I would switch to taking it in the AM.

I did a little "go off the selegiline and see what happens" experiment, and boy howdy, did I go boom. Back on it, and the brain works, but I can't sleep worth a darn. Maybe I should see if I can get some phenobarbitol.


> > > 3) Do you know anything about the liquid selegiline citrate? I've read that it's better than the selegiline hydrochloride pills but I have a feeling that's more of a political issue than a therapeutic one.
> >
> > It's moot to me. Only the hydrochloride tablets available in Canada.
> >
> > I suspect the sublingual preparations are better tolerated, and may avoid first-pass metabolism transformations. In gut uptake, the drugs run an enzyme gauntlet in the intestinal wall and mesentery, and then pass via the portal vein to the liver, where they get another shot at being enzymatically transformed. It looks like selegiline is substantially affected by first-pass metabolism, so I see this as a pharmacological issue, not a political one.
>
> The selegiline citrate is a liquid - not sublingual. It goes through the stomach. So in that respect it would be a more equal comparison. Perhaps I will do the experiment at some point.

I cannot see the point of having a liquid preparation of this drug (which is also available as a quick-dissolving tablet for sublingual use), if it is not for sublingual use. It may not say so on the label, but that's how I would use it, without question. And, also without question, sublingual use of the regular tablets has a greater beneficial effect, with fewer side effects. Avoiding first-pass metabolism seems to be an important aspect of omptimizing selegiline's effects.

> Have you given up on the selegiline yourself? The last I read it was bothering your asthma and creating GERD problems again. It's so frustrating when you find something that works but you have problems taking it.

Still trying to figure out how to best use it.

> Thanks again,
> Kara
>

Take care,
Lar

 

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poster:Larry Hoover thread:387192
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