Posted by Larry Hoover on November 10, 2004, at 13:05:29
In reply to Re: Vit E and increased death risk? » Larry Hoover, posted by JLx on November 10, 2004, at 12:19:04
> Sorry, I didn't realize that it was available online: http://www.annals.org/cgi/content/full/0000605-200501040-00110v1
>
> Some reaction: http://www.crnusa.org/PR04_1110CRNAIM.html
>
> JLI agree fully with the criticisms raised. Moreover, those studies with the greatest disparities in mortality were all very small studies (very low N). The larger studies showed little difference. Including the smaller studies skews the statistics.
Also, deeply embedded in the article was a comment that struck me.....one possible confound is the type of vitamin E supplied. There are eight isomers of vitamin E, but most vitamin E supps (the synthetic, cheaper varieties) are all of one single isomer. Perhaps the adverse health effects (if any) from high-dose vitamin E are due to displacement of the other isomers from their normal protective role?
Really, though, an all-cause mortality increase of 3 or 4% is not much to worry about.
I'll read it all again, and see what pops up.
Lar
poster:Larry Hoover
thread:412398
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/414263.html