Posted by Larry Hoover on October 15, 2004, at 13:29:22
In reply to Re: brain fog and creatine/methylation » Larry Hoover, posted by raybakes on October 15, 2004, at 12:55:36
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> > I'm glad you're helping to push my brain back into a good zone, Ray. Here are a few abstracts about creatine. I don't know if I own some, or not. But it's certainly going to be something I keep on my shelf.
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> Wow, thanks for all those abstracts Lar!You're welcome. I was just unpacking a big box of stuff I ordered in, and there was a 1 kilo jar of creatine.
> I've had creatine on my shelf for a year but always got a pounding headache when I took it. It was only when I found out that 70% of all methylation reactions are used to make creatine, that I tried it again. I needed to stock up on methyl donors before I took it (my favourite sublingual B12, folinic acid and betaine). When fully 'methylated' creatine feels brilliant for me! Interesting that creatine kinase is inhibited by mercury and other heavy metals.
Point made. I have a profound response to betaine, but I'm not certain the effect is only mediated via methyl donation. Methinks there's more to betaine than that, overall. Didn't know about that effect of mercury. I think my amalgams have injured me, and that seems a reasonable metabolic pathway to consider trying to strengthen.
> Creatine in some abstracts, has been found to protect dopamine and tyrosine hyroxylase too.
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> Do you know if the sulphation of dopamine is important in dopamine transport/storage?I don't see it that way. Not like DHEA-S. I think it's simply a way of inactivating dopamine from diet. 99% of the dopamine sulfation capacity in the periphery is in the intestinal wall. The only other place the enzyme is found is in accessory cells (glia, I think) in the brain. It mops up whatever amount of dopamine escapes MAO and COMT.
> Just seen a few references to free dopamine acting as an oxidant?
It might well be one, but there is so very little of it (free dopamine, as opposed to glucoronidated or sulfated (conjugated)), I think it's moot.
> Thanks,
>
> RayMy pleasure,
Lar
poster:Larry Hoover
thread:402926
URL: http://www.dr-bob.org/babble/alter/20040928/msgs/403398.html