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Re: exorphins » Larry Hoover

Posted by raybakes on October 13, 2004, at 10:39:53

In reply to Re: exorphins » raybakes, posted by Larry Hoover on October 12, 2004, at 13:32:43


> Hey. I'm just going to jump in here with a novel concept. Within the complex milk proteins and wheat proteins are sequences of amino acids which, if liberated during digestion, have opioid and hormonal acivity. There are numerous such sequences in milk proteins, including one of the better studied ones, beta-casomorphine-7. It is derived from the milk proteind casein, and as you can infer from the name, it is an endorphin-like opioid binding protein. It also directly mediates histamine release. So, it perturbs peristalsis, and inflames tissues, in the complete absence of classical allergic response mediated by immunoglobulins.
>
> The generic term for this class of substances is exorphin. I just thought I'd put a bug in Ray's brain. ;-)
>
> I found a paper a few years ago that described industrial milk processing techniques specifically engineered to ensure maximization of yield of exorphin sequences prior to the creation of processed cheese. I've heard people say that they crave certain "plastic" cheeses, and there may be some truth to that, via opiate-mediated addiction.
>
> Wheat has similar sequences. Wheat and milk intolerance can be due to processes entirely distinct from allergy. Individual sensitivity to these substances varies substantially, and can change over time. Once sensitized, it is possible that such sensitization is permanent. Ray, this might explain your rechallenge experience, with substantially exacerbated symptoms on re-exposure.

Thanks Lar, think it is quite possible that that may apply to me as I do really well on the enzyme DPP IV, developed for autistic children with wheat and milk intolerance - I'm not sure if DPP IV separates the gluten and casein away from the exorphin, or whether the DPP IV just replaces the child's own DPP IV bound by gluten and casein? Interestingly, mercury also binds DPP IV.....
and thanks for the bug too! :)

Ray


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