Posted by raybakes on October 6, 2004, at 13:42:27
In reply to Big news on panic, posted by Ron Jones on October 5, 2004, at 19:01:52
> New study from NIMH says that the brains of people with panic have 30 to 40% less HT1a serotonin receptors and a hyperactive T2A serotonin system.Activation of T2a eceptors causes the release of ne and dopamine.Activation of T1a receptors stops stops ne and dopamine release. Monkeys with their T1a receptors blocked act like people with panic.Blocking the release of ne stops panic.SSri drugs do this by downgradeing the t2a receptor.Fish oil inhibits the T2a receptors .SSri drugs upgrade T1a receptors.
Thanks, that's really interesting! Knew I had to learn more about the sub-types of receptors!
I threw a few words into google to see what other conditions modify the 5ht receptors. Chromium downregulates ht2a receptors, that suggests a blood sugar/insulin link. Also testosterone upregulated 5ht1a, but estrogen and cortisol upregulated 5ht2a - the conversion from testosterone to estrogen (estradiol) can be slowed by fish oil too!!
Just wonder whether 5HT2a upregulation has implications for breast and prostate cancer (raised estradiol), type 2 diabetes and associated vascular, brain, kidney and eye disease - if that's the case, when treating the body's neurotransmitter imbalances, we should perhaps also look at underlying causes that may cause chronic disease elsewhere in the body?
Ray
poster:raybakes
thread:399340
URL: http://www.dr-bob.org/babble/alter/20040928/msgs/399644.html