Posted by Larry Hoover on August 7, 2004, at 12:33:40
In reply to Re: Fish Oil, posted by Tendency on August 6, 2004, at 18:18:38
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> > EPA decreases inflammatory response.
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> If this assertion is not anecdotal please site (sic) sources.It is apparent by your conditional invocation of anecdote that you do not have a background in biochemistry. Perhaps it would be best if I linked to a site with a reasonable overview of the relevant eicosanoid/prostaglandin chemistry, so that you can get a grounding for subsequent discussion.
BTW, one cites references.
> > DHA has more of a direct effect on neuronal behaviour.
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> Again, sources please?That was a summary introductory statement, not intended to be interpreted literally. In the subsequent list of DHA-mediated processes, the statement was given its relevance. I do not cite all things I write, as much of it is simple biochemistry. I tend to reserve citations for novel and/or controversial findings.
> > DHA is also linked to changes in genetic regulation of neuron behaviour. There are substantial changes in genes which regulate energy metabolism, membrane protein expression, neuronal plasticity, and other beneficial changes. (See: http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=122397, Table 5)
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> ..perhaps that linkage can be established in *rats*..Perhaps? It has *clearly* been established in rats. The very same genes are operant in other mammals, including our own selves. It is unethical to perform similar experiments on humans, and is seldom even permitted in other primates, any more. Again, I suspect that unfamiliarity with the subject matter is what leads you to suggest that the relevance in Homo sapiens is conditional.
> > There is substantial evidence that man evolved on a diet that provided an omega-6:omega-3 ratio of about 1:1.
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> Such as?Once again, I believe it best to provide a background information source, rather than a series of technical citations. The diet of pre-agricultural man is the issue, as compared to the highly distorted diet resulting from dependency on grain crops, and meat derived from grain-fed animals. Here is a decent review of the evidence: http://faculty.smu.edu/jowillia/berardi_paleonutrition/williams_paleonutrition.htm
> > There is some controversy over whether supplementing with the shorter omega-3 fatty acid alpha-linolenic (e.g. flax oil) is sufficient to overcome the imbalance from diet, as there are five chemical reactions required to convert it to DHA. The yield, the efficiency of that process, has been estimated to be close to zero in men, and no more than 7% in women.
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> Source??I have posted the references to this data many times already.
> I see many claims here but nothing to back them up. Are these claims based upon clinical observation? Scientific study?
I can back up my scientific presentations, be certain of that. I seldom do so, for the reasons I have elucidated above.
> Mars conjuct (sic) Venus?
I don't appreciate sarcasm, particularly when I have not had the opportunity to clarify earlier remarks. I will refer this comment to Dr. Bob for assessment of its civility.
> Thanks for clarification.
When you have done some relevant reading, I welcome further discourse.
Lar
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poster:Larry Hoover
thread:356500
URL: http://www.dr-bob.org/babble/alter/20040718/msgs/375074.html