Posted by Larry Hoover on July 14, 2004, at 8:36:08
In reply to Re: SAMe, posted by nicko on July 10, 2004, at 6:59:34
Somehow, you slipped by me.
> Well i took your advice and ordered some B3 500mg tablets, I'll start with one a day and see how i go.
B3 could be niacin (nicotinic acid), or it could be niacinamide (nicotinamide). Do you know which one you're getting? It really matters.
> I am still willing to give SAMe a go, you said its ok to take with St johns wort, i currently take 4 SJW which = 1200mg should i reduce that if I'm going to take SAMe as well or will it be ok?
Take the smallest dose of SAMe, and take it for at least a week (if tolerated at all) before you even consider moving up one dose level. There is a possibility of interaction. Interaction is not necessarily a bad thing. It's a management issue. People take "drug cocktails" (polypharmacy) all the time, for mood disorders. All I'm saying is, manage it to reduce your risk of a bad reaction.
> I'm thinking at starting SAMe with half a tablet twice daily..seem ok?
Yes.
> I can't seem to find any information on mixing the 2 so i'm alittle concerned.
> Thanks
> NickoDose makes the poison. I recently started on a beta blocker, with a target of 10 mg/day. I could not tolerate 1 mg, developing severe peripheral edema. 1 mg isn't considered to be toxic, but it was intolerable for me. Some people can take 10 mg of that same beta blocker and get no benefit. It is theoretically possible that a little bit of SAMe, with SJW, *might* give an adverse reaction. Very unlikely, but you are concerned, so no problem, you manage the situation closely. Just like my doctor did, giving me 1 mg of the beta blocker to start out. Just discontinue the SAMe if you find it uncomfortable. Wait a couple days, and then try it again. If you get uncomfortable again, then it's probably not a good combination for you. But it might still be worth trying a third time, to remove all doubt. The small dose will not harm you, I can assure you of that. You might not like it, which is also worth assessing, but it will not hurt you.
Lar
poster:Larry Hoover
thread:363652
URL: http://www.dr-bob.org/babble/alter/20040613/msgs/365979.html