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Re: SAMe » Larry Hoover

Posted by Emme on July 8, 2004, at 22:07:05

In reply to Re: SAMe » Emme, posted by Larry Hoover on July 8, 2004, at 9:55:49


> > Is another salt of SAM-e preferable?
>
> I believe that there is a tert-butyl salt. Also a butane disulphanate. I see no risk in the alternatives.
>
> Here is a sample from a tosylate supplier:
> Which SAM-e should you take?
> Be sure to look for SAMe in enteric coated tablet form. Enteric coating ensures the proper and safe absorption of supplemental SAMe by the body.

I've got Nature Made. They're enteric coated. Unfortunately, I have to chop them up because 200 mg is too much. At the moment, I can only deal with 50 or 100 mg. My pdoc and I discussed it briefly and she thought that it would be okay to lose the enteric coating if I can't do the larger dose. From the broken edges, it is awfully bitter - no surprise there. I coat it with butter to make it swallowable.

> > What is worse about toluene-sulfonic acid than other forms?
>
> I just don't see that any intake of toluene-sulfonic acid is justified. It's a totally synthetic material (i.e. we have no natural way to detoxify it, except by fluke), and it has no known health benefits. Quite the contrary. I have never heard of any toluene compound that is safe.
>
> Really, you need to take the following with a grain of salt, as it deals with acute exposure to large amounts of the acid form (not the salt), but still....

Okay, so from looking at the MSDS, I won't inhale the acid form. ;) And yes, I guess it would be a bit like comparing the MSDS for NaCl and HCl. But it would be interesting to know what the fate of the tosylate is as it goes through the body.

> > Wow. 100 mg was too much and 50 mg puts me out.
>
> Thanks for letting me know. I suppose, if Bob permitted signature lines, mine would be something like: "Dosage and scheduling guidelines are simple starting points for determining your own tolerance. Your brain/body may vary."

Well, my body is just plain ridiculous about it. I need hamster-size doses. It makes the usual dosage guessing games even harder. OTOH, a sample pack of most things goes a long way....

Emme

 

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URL: http://www.dr-bob.org/babble/alter/20040613/msgs/364224.html