Posted by chemist on June 21, 2004, at 11:22:34
In reply to Re: Pyroluria: Larry H., chemist, anyone...any help? » chemist, posted by Simus on June 21, 2004, at 10:52:29
no problems, i learned a lot....i would go ahead and load up on the omega's as you suggest.....they are also good for mood stabilization......all the best, chemist
> Sorry to put you to so much work, Chemist, but thanks.
>
> >deficient in an enzyme called delta^{6} desaturase. as the name implies, desaturases take saturated fatty acids and desaturate (i.e., induce the formation of a double bond where there was formerly a single bond) the fatty acids. the designation omega-6 and omega-3 refers to the position of the double bond. so, if you are lacking in the delta^{6} desaturase, you have elevated levels of omega-3 c.f omega-6, which in turn leads (to among other things) to an important precursor for arachadonic acid, which in turn goes to things that help relieve pain, etc. (the stuff in question is cis-linoleic acid). now, pyroluria is the opposite, but the one abstract i am reading indicates that elevated cic-linoleic levels are not due to mutant delta^{6} desaturase, but to something else. so, fasting insulin levels get higher, and some compound they refer to as a urinary kryptopyrolle shows up. The part that interests me is that this condition has either been renamed or dismissed as being something that can be addressed with proper omega-3/omega-6 supplementation or ruling out diabetes (i'm uessing mellitus). heck, it's not even in the DSM-IV TR. maybe i'm looking in the wrong places, but it sounds like this could have been a medical hypothesis that didn't make the grade....in any event, i wish you well, and hope this helps (i sure learned a lot!)....all the best, chemist
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> It crossed my mind that it could be a medical hypothesis that didn't make the grade, but still I do test high for kryptopyroles and I fit all of the symptoms of "pyroluria". I just don't know exactly what to do with the info. Dr. Pfeiffer (no longer living) started the research on pyrolluria when working with schizophrenic patients, and Dr. Walsh at the Pfeiffer Clinic near Chicago is continuing his research. Well, thanks again. I will keep plugging along. It sounds like supplementing GLAs couldn't hurt though, huh?
poster:chemist
thread:358464
URL: http://www.dr-bob.org/babble/alter/20040613/msgs/358591.html