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Re:Neuroleptics brain specific antihistaminergic? » Jay2112

Posted by undopaminergic on February 12, 2023, at 12:00:25

In reply to Re:Neuroleptics brain specific antihistaminergic? » undopaminergic, posted by Jay2112 on February 9, 2023, at 19:10:51

> > > > >
> > > > > I found something that you might find useful:
> > > > >
> > > > > https://pubmed.ncbi.nlm.nih.gov/20021346/
> > > > >
> > > >
> > > > I'm very interested in trying a histamine H3-receptor antagonist (or inverse agonist), but none are clinically available.
> > > >
> > > > -undopaminergic
> > > >
> > >
> > > Do you know whether or not any H3 antagonists are in the pipeline for FDA approval?
> > >
> >
> > No, I don't know. But I was wrong: betahistine is mostly a histamine H3-receptor antagonist, and it is clinically available in Europe, including my location, but it was withdrawn from the market in the US.
> >
> > -undopaminergic
> >
>
> I took betahistine for almost 3 months (I am in Canada). It seemed to make me very depressed. I was taking it for inner-ear problems.
>
> Jay

H3 antagonists increase histaminergic neurotransmission, and should have stimulant-like effects. Maybe you have endogenously high histamine? Do you benefit from regular (H1) antihistamines?

-undopaminergic


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